Invasive Fungal Infections in Non-neutropenic Patients

Critically ill patients, particularly those with features of immunosuppression, are susceptible to invasive fungal infections (IFI), which pose significant diagnostic and therapeutic challenges. Candida and Aspergillus,... read more

Association Between Comorbid COPD and Prognosis of Patients Admitted to ICU for Non-COPD Reasons

Comorbid COPD increased the risk of 28-day mortality among patients admitted to the ICU for non-COPD reasons, especially for those admitted to the cardiac surgery recovery unit. A retrospective cohort study was performed... read more

Optimal Antibiotic Treatment Duration of Upper and Lower Respiratory Tract Infections

The available evidence for non-ICU community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (AECOPD) supports a short-course treatment duration of 5 days in patients who have clinically improved. Efforts... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

COVID-19 ARDS Patients vs. Patients with ARDS

Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS... read more

Glucose Metabolism Disorders: Pre-hospital Oxygen Therapy and Saturation Variability in COVID-19 Patients

The COVID-19 pandemic has revealed that viruses can have multiple receptor properties, penetrating various tissues and causing mutations in various genes, thus promoting a range of metabolic disorders. The purpose of... read more

Risk Factors of Post-intubation Hypotension in Severe Pneumonia Patients

Post-intubation hypotension (PIH) was one of the serious complications after Endotracheal intubation (ETI) in Severe pneumonia (SP) patients. The risk factors of PIH were investigated in SP patients to provide a theoretical... read more

Two weaning strategies for NIV in COPD patients with ARF

Non-Invasive Ventilation (NIV) is a crucial therapy for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) with hypercapnic respiratory failure. Research has shown that NIV can decrease the rate... read more

Pneumocystis Jirovecii Pneumonia in Patients with and without Chronic Pulmonary Disease

Procalcitonin level, pneumothorax, neutrophil count at 14 days, and hemoglobin level at 14 days after admission were poor prognostic indicators among patients with NCPD-PJP. Neutrophil count was related with poor prognosis... read more

Proposal for a 4-Level Classification System of Severe COPD Exacerbation According to Healthcare Resource Utilization

The definition of an acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) has been modified several times the last decade in Global Initiative for COPD (GOLD) recommendations. According to the updated GOLD... read more

Ineffective Airway Clearance Nursing Diagnosis & Care Plans

Ineffective airway clearance is the inability to clear secretions or obstructions from the respiratory tract. This can be detrimental to breathing and create complications. Secretions can be problematic as a result of... read more

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

During the COVID-19 pandemic, healthcare delivery was affected in various ways. For example, acute and chronic cardiovascular diseases (CVDs) and events were less frequently observed in hospitals, both because public health... read more

Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients

Remdesivir, an antiviral medication, may benefit patients who are infected with mild or moderate forms of COVID-19 infection. Several research findings have suggested the safety and efficacy of remdesivir for a five- to 10-day... read more

Significant Persistent Pain Symptoms After Critical Care Illness

Persistent pain could be a common health problem after critical illness care. Our data also suggest that there is a lack of specific follow-up after ICU discharge. Given the major consequences on patient quality of life,... read more

MACE in Acute Exacerbation of COPD – Troponin I – A Dramatic Predictor

The burden of COPD is rising due to continued exposure to risk factors that trigger lung inflammation and repeated secondary infections thereby contributing to the third leading cause of death globally. More COPD deaths... read more

MACE in Acute Exacerbation of COPD – Troponin I – A Dramatic Predictor

Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine

This issue of Clinics in Chest Medicine, guest-edited by Dr. Gerard Criner and Dr. Bartolome Celli, is focused on Chronic Obstructive Pulmonary Disease. Topics discussed in this issue include but are not limited to: COPD... read more

Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine

Sotrovimab Effect Among High-risk COVID-19 Patients

Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more

Patients’ Perspectives on Point-of-Care Diagnostics in Acute COPD Exacerbations

Patients' perspectives showed that point-of-care diagnostics and treatment of acute COPD in exacerbation was considered a qualitative offer by the patients and their relatives. At the same time, it was crucial that the emergency... read more

Procalcitonin in the ED: The evidence

Is procalcitonin of any value in the emergency department? Considering that procalcitonin testing is not available in any of my hospitals, I have never been all that interested in this question. But Swami requested a procalcitonin... read more

Noninvasive Respiratory Support for COVID-19 Patients: When, for Whom, and How?

The significant mortality rate and prolonged ventilator days associated with invasive mechanical ventilation (IMV) in patients with severe COVID-19 have incited a debate surrounding the use of noninvasive respiratory support... read more

Prescription Rates Changes for Inhaled Corticosteroids During the COVID-19 Pandemic

During the COVID-19 pandemic, despite early concerns the impact oral corticosteroids might have on the effects of acute COVID-19 reported by the WHO and the potential severity of disease in patients with asthma and chronic... read more

Facemask vs. Helmet – Noninvasive Ventilation

We use Noninvasive ventilation (NIV) to treat various disease processes, such as acute hypercapnic and hypoxemic respiratory failure, post-extubation failure, and neuromuscular diseases. Data supports NIV use in some conditions,... read more