Extubation in the Operating Room After Elective On-pump CABG Surgery

Although immediate extubation in the operating room following on-pump coronary artery bypass graft (CABG) surgery did not show significant differences in ICU or hospital length of stay (LOS), mortality, or ICU readmission... read more

Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients

In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more

Bundle of Care Effectiveness on Tolerance of Awake-prone Positioning in ARF Patients

In the evaluated population of patients with COVID-19-related ARF, implementing a bundle-of-care strategy was associated with a longer AW-PP exposure and a reduced risk of endotracheal intubation. In this secondary analysis... read more

Cardiovascular Complications of COVID-19: Acute and Long-Term Impacts

This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology... read more

Cardiovascular Complications of COVID-19: Acute and Long-Term Impacts

Helmet CPAP as NIV for COVID-19 Patients

The COVID-19 pandemic has challenged healthcare systems globally, highlighting the need for effective respiratory support strategies. Helmet continuous positive airway pressure (CPAP) has emerged as a potential noninvasive... read more

Tracheostomy in COVID-19 Patients

Tracheostomy is common in critically ill COVID-19 patients. In patients predicted to need a tracheostomy at some point, early, rather than late, tracheostomy might be a means to reduce the time spent in ICU. However,... read more

Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors

The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more

COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis

COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more

COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients

Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more

Prone Position: Achieving Nutritional Goals

Critically ill patients in the prone position had longer hospital stays and higher mortality rates, while being more likely to initiate and remain on enteral nutrition for a longer period. However, no significant differences... read more

Nebulized Long-Acting Bronchodilators to Treat ARF in an Older Patients

Although long-acting bronchodilators are not approved to treat acute respiratory failure (ARF), the older adult in this case clinically improved after three doses of revefenacin and arformoterol. Additional studies are... read more

Different Anticoagulation Regimens Effectiveness in Critically Ill Patients

This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy... read more

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

Cytokine Storm Syndrome

Mortality Predictor with sPAP in Elderly Critically Ill with Severe COVID-19 Pneumonia

Mortality in general ARDS patients remains high, with many experiencing long-lasting sequelae. Numerous studies have been conducted to identify predictors of mortality in COVID-19 patients, particularly regarding right ventricular... read more

Diastolic Dysfunction Increases AKI Rick in COVID-19 Patients

Diastolic dysfunction increases the risk of acute kidney injury (AKI) in patients with severe COVID-19. Using point-of-care ultrasound (PoCUS) to assess left ventricular diastolic function in the ICU may be a useful parameter... read more

Unlocking the Predictive Power of Nutritional Scores in Septic Patients

This study highlights the significant prognostic utility of nutritional status evaluation in septic patients admitted to internal medicine wards. Among the tools evaluated, the mNUTRIC score—likely because of its dual... read more

Analgosedation and Delirium Practices in Critically Ill Patients

Before the COVID-19 pandemic, the management of analgosedation was characterized by the predominant use of targeted protocols that favored priority on mild and dynamic sedation in critically ill patients. During the pandemic... read more

AKI and Mortality Predictors of Systemic Autoimmune Diseases and COVID-19

The present study highlights renal parameters and outcomes associated with various systemic autoimmune diseases and COVID-19. Patients who presented with low oxygen saturation (... read more

APRV vs. BIPAP Ventilation in COVID-19 Associated ARDS

Despite of higher mean tidal volumes and higher mean airway pressures in airway pressure release ventilation (APRV) vs. biphasic positive airway pressure (BIPAP), both modes did not present an increased risk of volu- or barotrauma... read more

Cytokeratin-18 Levels in COVID-19 Patients

This study analyzed 176 samples, including 63 ICU-admitted patients and 88 non-ICU-admitted patients. A substantial difference was found between the AST and CK-18 levels of the patients receiving ICU care and those who did... read more

New Insights: Inhaled Nitric Oxide in Severe COVID-19 Patients

This study provides novel insights into the use of inhaled nitric oxide in severe ARDS COVID-19 patients. Specifically, we demonstrate that the iNO effect of oxygenation improvement is delayed with a prolonged feature that... read more

Cellular Therapy with Mesenchymal Stromal Cells in Sepsis

Cellular therapy with mesenchymal stromal cells (MSCs) is a promising therapeutic modality in sepsis. Positive effects are mainly associated with frequent infusions and the dose of 1 × 106 cell/kg. Larger scale studies... read more