COVID-19: Restricted Visitation Policies in Acute Care Settings

COVID-19: Restricted Visitation Policies in Acute Care Settings

Patients, families, and healthcare professionals were impacted by restricted visitation polices in acute care settings during COVID-19. The consequences of this approach on patients and families are understudied and warrant... read more

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

In this systematic review, we evaluated the temporal progression of clinical abnormalities experienced by patients who recovered from an infection with SARS-CoV-2, starting with a mean of 30 days post–acute illness and... read more

COVID-19 Handbook: Navigating the Future of Healthcare

COVID-19 Handbook: Navigating the Future of Healthcare

The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more

Longitudinal Respiratory Subphenotypes in COVID-19 Patients with ARDS

Longitudinal Respiratory Subphenotypes in COVID-19 Patients with ARDS

COVID-19-related ARDS has no consistent respiratory subphenotype. Patients diverged from a fairly homogenous to a more heterogeneous population, with trajectories of ventilatory ratio and mechanical power being the most discriminatory.... read more

Suboptimal COVID-19 Vaccination Coverage Implications in Florida and Texas

Suboptimal COVID-19 Vaccination Coverage Implications in Florida and Texas

In July, 2021, another wave of COVID-19 began in the USA as the highly infectious delta (B.1.617.2) SARS-CoV-2 variant drove outbreaks predominantly affecting states with relatively low vaccination coverage. Some US states... read more

ECMO for COVID-19

ECMO for COVID-19

Mortality after ECMO for patients with COVID-19 worsened during 2020. These findings inform the role of extracorporeal membrane oxygenation (ECMO) in COVID-19 for patients, clinicians, and policy makers. In 2020, 4,812... read more

Dexamethasone 12 mg vs. 6 mg for COVID-19 Patients with Severe Hypoxia

Dexamethasone 12 mg vs. 6 mg for COVID-19 Patients with Severe Hypoxia

Among patients with COVID-19 and severe hypoxia, dexamethasone 12 mg did not result in statistically significantly more days alive without life support at 28 days than dexamethasone 6 mg. However, the confidence interval... read more

Continuous Positive Airway Pressure and Pronation Outside the ICUs in COVID-19 ARDS

Continuous Positive Airway Pressure and Pronation Outside the ICUs in COVID-19 ARDS

Continuous positive airway pressure with patient mobilization (including pronation) was effective and safe in patients with ARDS due to COVID-19 managed outside the intensive care unit setting during the pandemic. Of 90... read more

Therapeutic Anticoagulation vs. Usual Care in Noncritically Ill COVID-19 Patients

Therapeutic Anticoagulation vs. Usual Care in Noncritically Ill COVID-19 Patients

Among noncritically ill patients with COVID-19 infection, therapeutic anticoagulation with heparin improved the proportion of patients who survived without need for organ support. Therapeutic anticoagulation was associated... read more

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt

Melbourne’s second wave of COVID-19 last year, which led to a lockdown lasting more than 100 days, provided us with many lessons about controlling transmission. Some of these are pertinent as New South Wales endures its... read more

COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?

COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?

In CRITICALLY ILL patients with COVID-19, an initial strategy of therapeutic-dose anticoagulation is not associated with a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular... read more

Convalescent Plasma for COVID-19 in Hospitalised Patients

Convalescent Plasma for COVID-19 in Hospitalised Patients

Convalescent plasma (CP) and standard of care (SOC) did not result in a higher proportion of clinical improvement on at day 28 in hospitalised patients with COVID-19 compared to SOC alone. This is an investigator-initiated,... read more

Predicting Adverse Outcomes in COVID-19 Patients Using BV5%

Predicting Adverse Outcomes in COVID-19 Patients Using BV5%

Evidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesized that a significant decrease in the percentage of blood vessels with... read more

COVID-19 Immune Evasion by the B.1.427/B.1.429 Variant of Concern

COVID-19 Immune Evasion by the B.1.427/B.1.429 Variant of Concern

As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern because they... read more