Tag: COVID-19
Succinate-containing Crystalloid Solution in Correction of COVID-19-associated Endotheliopathy
The use of a succinate-containing infusion solution in patients with a new coronavirus infection promotes a more rapid and sustainable correction of COVID-19-associated endotheliopathy, which, in turn, is manifested by a... read more
Predictors of Functional Impairment in Severe COVID-19 Patients Two Months After Discharge
The Post-COVID-19 Functional Status (PCFS) scale is a validated tool for assessing functional impairment in COVID-19 patients. While this retrospective monocentric study identified multiple risk factors associated with... read more
Early Antiviral Use and Supplemental Oxygen Decrease the Risk of Secondary Bacterial Infections
This nested case control study shows that early use of antiviral agents and non-invasive oxygen supplementation leads to decreased susceptibility to secondary bacterial infections. On the other hand, use of antibiotics... read more
Cardiac Damage in Patients Infected with Different COVID-19 Variants of Concern
Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently. We conducted a single-center retrospective cohort analysis comparing biomarkers and... read more
Long-term Prevalence of PTSD Symptom in Family Members of Severe COVID-19 Patients
The prevalence of PTSD-related symptoms among family members of severely ill COVID-19 patients stayed high up to 18 months after the patients' ICU discharge. Some showed delayed onset of PTSD-related symptoms in the remote... read more
In COVID-19 Patients Supported with ECMO, ICU Mortality Is Associated with the Blood Transfusion Rate
Three-quarters of patients 3 days in these centers between July 2020 and November 2021 were included in the analysis.... read more
Predicting ICU Admission in COVID-19-Infected Pregnant Women Using Machine Learning
Routinely collected clinical and laboratory data of COVID-19-infected pregnant women may help recognize high-risk groups who are more liable for complications and more severe course or prognosis and require an ICU admission.... read more
Temporary ICU – Preparedness Concept to Increase Capacity
The temporary ICU (TICU) concept demonstrates promising potential in enhancing preparedness and maintaining critical care surge capacity during pandemics or mass casualty incidents. While shortages of medical equipment,... read more
Prediction of Prolonged Mechanical Ventilation in the ICU via Machine Learning
Early recognition of risk factors for prolonged mechanical ventilation (PMV) could allow for early clinical interventions, prevention of secondary complications such as nosocomial infections, and effective triage of hospital... read more
Early Tracheostomy in Ventilated COVID-19 Patients Reduces VAP Incidence
Tracheostomy can reduce mechanical ventilation (MV) duration, ICU and hospital length of stay (LOS), and ventilator-associated pneumonia (VAP) risk in critically ill patients. The timing of tracheostomy in COVID-19 patients... read more
Antibiotic prophylaxis reduced broad-spectrum antibiotics and length of stay in ICU patients with alcohol withdrawal induced refractory delirium tremens
Administration of TMP-SMX prophylaxis reduced the use of broad-spectrum antibiotics and ICU LOS in ICU-treated rDT patients. The retrospective study design should be considered when interpreting the results, and prospective... read more
Oxygenation Indices and Early Prediction of Outcome in Hypoxemic Patients with COVID-19 Pneumonia Requiring NIV Respiratory Support in Pulmonary Intermediate Care Unit
Oxygenation indices (OI) showed different effectiveness in predicting NIRT failure within 24 h of treatment in COVID-19 related pneumonia. This may be due to the multi-factorial pathophysiology of hypoxemia. Our study... read more
Risk Factors for Secondary Organizing Pneumonia and Acute Fibrinous and Organizing Pneumonia in Patients with COVID-19 Pneumonia
Based on our findings, we observed that age ≥50 years, diabetes mellitus, and severe hypoxemia on admission (SpO2 ... read more
Extended Prone Position and 90-Day Mortality in Mechanically Ventilated Patients with COVID-19
Extended prone positioning (PP) was associated with improved 90-d survival in subjects with COVID-19 undergoing mechanical ventilation for severe ARDS. These findings suggest the potential benefit of EPP in the management... read more
The Pathophysiology of Happy Hypoxemia in COVID-19
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional... read more
Relationship between Concentrations of Oxygen and Levels of Oxidative Stress in Patients Receiving Oxygen Therapy for Severe COVID-19 Pneumonia
We evaluated the potential of high-flow oxygen therapy to increase oxidative stress and inflammation in COVID-19 patients. Our observation of decreased MDA levels when transitioning hypertensive patients from high-flow to... read more
ARDS and Prone Positioning
Prone positioning has been a treatment option for acute respiratory distress syndrome in critically ill patients. Since the COVID-19 pandemic, awake prone positioning has been utilized as a treatment option for non-intubated... read more
Management of Refractory COPD
Chronic obstructive pulmonary disease (COPD) is a common condition with an estimated global prevalence of almost 12 percent in adults over age 30 years [1-3]. Prior to the onset of the COVID-19 (coronavirus disease 2019)... read more
Invasive Fungal Infections in Non-neutropenic Patients
Critically ill patients, particularly those with features of immunosuppression, are susceptible to invasive fungal infections (IFI), which pose significant diagnostic and therapeutic challenges. Candida and Aspergillus,... read more
Microbial Dynamics and Pulmonary Immune Responses in COVID-19 Secondary Bacterial Pneumonia
Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated... read more
Outcomes and inflammation changes in different types of immunocompromised patients with critically ill COVID-19 admitted to ICU
Critically ill COVID-19 patients admitted to the ICU exhibit distinct clinical outcomes based on their immunosuppression status, with cancer patients facing the highest mortality rate due to variations in inflammatory responses... read more
