The Impact of COVID-19 Pandemic on Respiratory Syncytial Virus Infection in Children

We observed a lower incidence of RSV infection and a lower rate of hospitalization for RSV during the COVID-19 pandemic. The second RSV season during the COVID-19 pandemic began earlier, lasted longer, and had a lower frequency.... read more

Prediction Model for Safe Early Discharge of Patients with an Infection

By combining readily available parameters, we developed and internally validated a prediction model for safe, early discharge among patients. Further research, preferably in a multi-center setting, is warranted to externally... read more

Predictive Value of Diaphragm and Lung Ultrasonography for Weaning Failure in Critically Ill Patients with ARF Due to COVID-19 Pneumonia

Patients undergoing mechanical ventilation due to respiratory failure require a comprehensive approach to determine the optimal timing for weaning from ventilatory support. Evaluating respiratory mechanics, maximal muscle... read more

Plasma Bioactive Adrenomedullin Predicts Mortality and Need for Dialysis in Critical COVID-19

In this study, serial bio-ADM samples in the ICU had limited predictive power for mortality in critically ill COVID-19 patients when looking at absolute values. Still, relative changes over time showed a much better prediction.... read more

Aspirin Reduces the Need for Mechanical Ventilation by Nearly Half For COVID-19 Patients

Patients hospitalized with COVID-19 and taking aspirin were nearly half as likely to require mechanical ventilation as those with COVID-19 not taking the drug, according to a study of adult patients. The patients were... read more

Sex Differences in the Outcome of Critically Ill COVID-19 Patients

Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females... read more

Functional Dependence Following ICU-treated Sepsis

Sepsis survivorship was associated with a broad range of new impairments and led to functional dependence in around one quarter of patients. Targeted measures are needed to mitigate the burden of this Post-Sepsis-Syndrome... read more

Veno-Arterial-Venous ECMO in a Patient Undergoing Dialysis and Having Cardiopulmonary Failure Due to COVID-19

COVID-19 can cause cardiomyopathy, a rare cardiovascular disorder that can lead to cardiogenic shock. The cardiac and respiratory symptoms may not occur simultaneously, and it is possible to switch to veno-arterial-venous... read more

Adiposity and Mortality Among ICU Patients with COVID-19 and Non-COVID-19 Respiratory Conditions

Obesity is associated with higher mortality among COVID-19 patients, but lower mortality among non-COVID-19 respiratory patients. These associations appear vulnerable to confounding/selection bias in both patient groups,... read more

Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

Cytokine Storm Syndrome

Corticosteroid Treatment and Survival in Critically Ill COVID-19 Patients

Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid... read more

Predictive Biomarkers of Mortality in ICU Patients with Severe COVID-19

This study shows changes in hematological, biochemical, and inflammatory parameters in COVID-19 non-surviving patients. Lymphopenia, neutrophilia, and thrombocytopenia, as well as increased levels of CRP, AST, creatinine,... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

Predictors of High-flow Nasal Cannula Failure in COVID-19 Patients

A retrospective cohort study was conducted during the months of March and May 2021. Data collection was based on a follow-up of 156 hospitalized patients with a diagnosis of COVID-19 who were users of high-flow nasal cannula... read more

Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients

A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more

Influenza and COVID-19 Vaccination Rates Among Children Receiving Long-Term Ventilation

Children with tracheostomy and HV are at high risk of morbidity and mortality from viral ARIs. Among MyTRaCh enrollees, we found significant discrepancy between influenza and COVID-19 vaccination status. Compared with... read more