Tag: COVID-19
APRV vs. BIPAP Ventilation in COVID-19 Associated ARDS
Despite of higher mean tidal volumes and higher mean airway pressures in airway pressure release ventilation (APRV) vs. biphasic positive airway pressure (BIPAP), both modes did not present an increased risk of volu- or barotrauma... read more
Cytokeratin-18 Levels in COVID-19 Patients
This study analyzed 176 samples, including 63 ICU-admitted patients and 88 non-ICU-admitted patients. A substantial difference was found between the AST and CK-18 levels of the patients receiving ICU care and those who did... read more
New Insights: Inhaled Nitric Oxide in Severe COVID-19 Patients
This study provides novel insights into the use of inhaled nitric oxide in severe ARDS COVID-19 patients. Specifically, we demonstrate that the iNO effect of oxygenation improvement is delayed with a prolonged feature that... read more
Cellular Therapy with Mesenchymal Stromal Cells in Sepsis
Cellular therapy with mesenchymal stromal cells (MSCs) is a promising therapeutic modality in sepsis. Positive effects are mainly associated with frequent infusions and the dose of 1 × 106 cell/kg. Larger scale studies... read more
Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection
The interplay of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and Clostridioides difficile infection (CDI) poses a critical clinical challenge. The resultant inflammatory milieu and its impact... read more
Specialty Imaging: HRCT of the Lung
Part of the highly regarded Specialty Imaging series, HRCT of the Lung, third edition, reflects the many recent changes in HRCT diagnostic interpretation. An easy-to-read bulleted format and thousands of state-of-the-art... read more
Impact of Extended-course Oral Nirmatrelvir/Ritonavir in Established Long COVID
Extended courses of nirmatrelvir/ritonavir may have meaningful benefits for some people with Long COVID but not others. We encourage researchers to study how and why nirmatrelvir/ritonavir benefits some and what course length... read more
Anticoagulation Among COVID-19 Patients
In this prospectively designed meta-analysis of randomized trials, administration of therapeutic- compared with prophylactic-dose anticoagulation with heparins to patients hospitalized for COVID-19 was associated with 23%... read more
Immune Cell-Based vs. Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients
This study aimed to assess the prognostic value of an array of biomarkers regarding the likelihood of a lethal outcome in critically ill COVID-19 patients. We took advantage of the opportunity to classify them into immune... read more
Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era
The most common pathogens isolated in our ventilator-vssociated pneumonia (VAP) patients were Acinetobacter spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. Resistance to the major classes... read more
Invasive Mechanical Ventilation Strategies For ICU Patients with COVID-19
Lung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID-19, but barotrauma, prolonged ventilation and death occurred frequently. A total of 774 patients were invasively... read more
Passport to Successful Outcomes for Patients Admitted to ICU: Meeting Patient Goals of Care
The second edition builds upon the previous content, exploring new and emerging evidence to enhance the structure and content of rehabilitation provided. It considers the additional impact of COVID-19 throughout each chapter.... read more
Atrial Fibrillation Status and Associations with Adverse Clinical Outcomes in COVID-19 Patients
COVID-19 patients with atrial fibrillation (AF) are at high risk of adverse clinical outcomes. Such patients may need increased surveillance and consideration for early anticoagulation. Patients admitted with COVID-19... read more
Plasma Proteome Temporal Changes Associated with Sepsis Mortality
Our proteomics approach revealed significant associations between changes in the plasma proteome within the first days of sepsis and mortality as well as disease severity. We identified and characterised the underlying... read more
72‐h Infusion of Prostacyclin in Mechanically Ventilated Patients with Pulmonary Infection and Endotheliopathy
Acute respiratory failure (ARF) is common in critically ill patients, and 50% of patients in intensive care units require mechanical ventilation. The COVID‐19 pandemic revealed that COVID‐19 infection induced ARF... read more
Succinate-containing Crystalloid Solution in Correction of COVID-19-associated Endotheliopathy
The use of a succinate-containing infusion solution in patients with a new coronavirus infection promotes a more rapid and sustainable correction of COVID-19-associated endotheliopathy, which, in turn, is manifested by a... read more
Predictors of Functional Impairment in Severe COVID-19 Patients Two Months After Discharge
The Post-COVID-19 Functional Status (PCFS) scale is a validated tool for assessing functional impairment in COVID-19 patients. While this retrospective monocentric study identified multiple risk factors associated with... read more
Early Antiviral Use and Supplemental Oxygen Decrease the Risk of Secondary Bacterial Infections
This nested case control study shows that early use of antiviral agents and non-invasive oxygen supplementation leads to decreased susceptibility to secondary bacterial infections. On the other hand, use of antibiotics... read more
Cardiac Damage in Patients Infected with Different COVID-19 Variants of Concern
Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently. We conducted a single-center retrospective cohort analysis comparing biomarkers and... read more
Long-term Prevalence of PTSD Symptom in Family Members of Severe COVID-19 Patients
The prevalence of PTSD-related symptoms among family members of severely ill COVID-19 patients stayed high up to 18 months after the patients' ICU discharge. Some showed delayed onset of PTSD-related symptoms in the remote... read more
In COVID-19 Patients Supported with ECMO, ICU Mortality Is Associated with the Blood Transfusion Rate
Three-quarters of patients 3 days in these centers between July 2020 and November 2021 were included in the analysis.... read more
Predicting ICU Admission in COVID-19-Infected Pregnant Women Using Machine Learning
Routinely collected clinical and laboratory data of COVID-19-infected pregnant women may help recognize high-risk groups who are more liable for complications and more severe course or prognosis and require an ICU admission.... read more
