Tag: COVID-19
Dexamethasone Systemic Effects in Severe COVID-19
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk... read more
The Airway Manual: Practical Approach to Airway Management
The book provides up-to-date and easy to understand information on airway management with special emphasis on practical management along with required theory background and key points. It covers all aspects of airway management... read more
Emergency Department Disposition and Mortality in COVID‐19 Patients with ARDS
Compared to direct ICU admission, admission from the ED to the ward is associated with increased mortality in patients who meet COVID‐19 ARDS criteria during their hospitalization, despite lower 4C and similar SAPS‐III... read more
Endothelial Dysfunction and Persistent Inflammation in Severe Post-COVID-19 Patients
Six months after ICU discharge from severe ARDS secondary to COVID-19, patients with gas exchange impairment exhibit evidence of systemic inflammation, along with elevated ICAM-1 levels, ultimately resulting in increased... read more
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS
The extended lung protection with strict control of ΔP for moderate to severe ARDS plus deranged mechanics is feasible and could be implemented in this pilot study with some beneficial impact on the recovery of lung function.... read more
Early Ketamine Sedation Outcomes Among Mechanically Ventilated COVID-19 Patients
In a diverse sample of U.S. hospitals, about one in 30 patients mechanically ventilated with COVID-19 received ketamine infusions. Early ketamine may have an association with higher hospital mortality, increased total cost,... read more
Secretomic Approach Value for Distinguishing Patients with COVID-19 Viral Pneumonia Among ICU Patients with Respiratory Distress
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV-ICU). To better manage VPP, it is therefore interesting to better understand... read more
Improving Outcomes in Nosocomial Pneumonia
Nosocomial pneumonia (NP) represents a leading nosocomial infection and results in substantial morbidity and cost. Over the last several years, the evidence has evolved which directs our approach to NP. Specifically, the... read more
Two weaning strategies for NIV in COPD patients with ARF
Non-Invasive Ventilation (NIV) is a crucial therapy for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) with hypercapnic respiratory failure. Research has shown that NIV can decrease the rate... read more
Chest Computed Tomography Severity Score at ICU Admission and Respiratory Outcomes
COVID-19 patients with >50% lung involvement on Chest-CT admission presented higher chances to stay longer on invasive mechanical ventilation and more chances to developed ventilator-associated pneumonia. 121 patients... read more
Anticipating the Future of the COVID-19 Pandemic
The initial instance of a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was observed in December 2019 in the city of Wuhan, China. Subsequently, the virus disseminated expeditiously across the globe,... read more
COVID-19 Airway Management and Ventilation Strategy for Critically Ill Older Patients
This book describes the issues and challenges that clinicians encountered in the management of older critically ill patients during the COVID-19 pandemic, and offers practical information on how to manage them. Older... read more
Omadacycline Treatment of Severe Pneumonia Complicated with ARDS During COVID-19
Metagenomic next-generation sequencing (mNGS) has a significant value in the diagnosis of Chlamydia psittaci infection. Timely treatment of omadacycline can improve prognosis and provide a promising new option for the treatment... read more
Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU
We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more
Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis
Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically as a result of the COVID-19 pandemic. In both COVID-19 and non-COVID... read more
Intravenous Vitamin C for COVID-19 Patients
In hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support–free days and hospital survival. Enrollment was terminated after statistical triggers... read more
Genetic Causal Factors of ARDS
This comprehensive study highlights the importance of utilizing the MR-pheWAS framework in unraveling the complex etiology and pathogenesis of ARDS, and further underlines the value of integrating blood-based biomarkers into... read more
COVID-19 Severity and 2-year Prevalence of Physical Symptoms
Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence... read more
Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation
A randomized clinical trial in Belgium finds that convalescent plasma reduces death rates by about 10% in COVID-19 patients requiring invasive mechanical ventilation. University of Liege researchers led the open-label... read more
When Fear Takes Control: The Multidrug Resistance Story During Pandemics
The COVID-19 pandemic was an unanticipated event which revealed our lack of preparedness for dealing with large numbers of infectious patients whilst maintaining excellent care quality. Notable problems arose with AMS... read more
HFNC vs. CPAP in COVID-19 Patients with ARDS in ICU
Acute hypoxic respiratory failure in coronavirus disease 2019 (COVID-19) pneumonia has been treated with oxygen delivered by oxygen masks and non-invasive ventilation (NIV) with continuous positive airway pressure (CPAP),... read more
