Shedding Light on a Hidden Source of Septic Shock with POCUS

Shedding Light on a Hidden Source of Septic Shock with POCUS

Septic shock has a high mortality rate, estimated to be higher than 40% [1], increasing as time passes without appropriate treatment. Hence, correct diagnosis of the cause of sepsis is essential to provide correct antibiotic... read more

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children

In this cohort study of 315 children with COVID-19 and 1402 children with seasonal influenza, there were no statistically significant differences in the rates of hospitalization, admission to the intensive care unit, and... read more

Hydroxychloroquine With or Without Azithromycin

Hydroxychloroquine With or Without Azithromycin

Among patients hospitalized with mild-to-moderate COVID-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. A total of 667 patients... read more

Bedside ECHO To Diagnose Native Valve Infective Endocarditis

Bedside ECHO To Diagnose Native Valve Infective Endocarditis

Infective endocarditis (IE) is an important pathology to detect in the Emergency Department (ED), but the diagnosis is too often delayed or missed. IE ticks many boxes as a diagnosis we can "own" in Emergency Medicine (EM): 1.... read more

Right Heart Thrombus in Transit Diagnosed With Focused Cardiac Ultrasound

Right Heart Thrombus in Transit Diagnosed With Focused Cardiac Ultrasound

Pulmonary embolism (PE) is a potentially fatal entity that is frequently diagnosed in the emergency department (ED). Emergency physicians (EPs) routinely perform focused cardiac ultrasound (FOCUS) to support a prompt ED diagnosis... read more

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children

High respiratory variability during spontaneous breathing trials is independently associated with extubation failure in children, with very high rates of extubation failure when these children develop postextubation upper... read more

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus... read more

Biomarkers of Sepsis: Time for a Reappraisal

Biomarkers of Sepsis: Time for a Reappraisal

The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more

Patients in Hospital with COVID-19 Using the ISARIC WHO Clinical Characterisation Protocol

Patients in Hospital with COVID-19 Using the ISARIC WHO Clinical Characterisation Protocol

ISARIC WHO CCP-UK is a large prospective cohort study of patients in hospital with covid-19. The study continues to enrol at the time of this report. In study participants, mortality was high, independent risk factors were... read more

High Risk of Thrombosis in Patients with Severe COVID-19

High Risk of Thrombosis in Patients with Severe COVID-19

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more

New NICE Guidelines on VTE Management

New NICE Guidelines on VTE Management

In the midst of everything that is going on with COVID-19 it is easy to see how important non coronavirus stuff can get overlooked. But we still need to keep our eyes open. After a 3 year process involving many meetings,... read more

Prediction Models for Diagnosis and Prognosis of COVID-19 Infection

Prediction Models for Diagnosis and Prognosis of COVID-19 Infection

Prediction models for covid-19 are quickly entering the academic literature to support medical decision making at a time when they are urgently needed. This review indicates that proposed models are poorly reported, at high... read more

Surviving Sepsis Campaign Guidelines on the Management of Critically Ill Adults with COVID-19

Surviving Sepsis Campaign Guidelines on the Management of Critically Ill Adults with COVID-19

The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. The novel severe acute respiratory syndrome coronavirus... read more

Where There Is No Doctor: A Village Health Care Handbook

Where There Is No Doctor: A Village Health Care Handbook

This updated reprint features updated medication information, a newly revised family planning chapter, new treatments for a variety of infections, and more. All Hesperian books are regularly updated and reprinted to reflect... read more