Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

The elderly patient presenting to the ED with nonspecific symptoms remains a diagnostic and therapeutic challenge. Often, these patients arrive with general complaints ranging from altered mental status to weakness, subjective... read more

Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

New Guidelines for Hospital-acquired Pneumonia/Ventilator-associated Pneumonia

American and European guidelines have many areas of common agreement such as limiting antibiotic duration. Both guidelines were in favor of a close clinical assessment. Neither recommended a regular use of biomarkers but... read more

New Guidelines for Hospital-acquired Pneumonia/Ventilator-associated Pneumonia

Antibiotic Treatment of Hospital-acquired Pneumonia

Although more prospective therapy trials of Hospital-acquired Pneumonia (HAP) are needed, based on currently available data, it is possible to use an approach that provides appropriate therapy without the overuse of broad-spectrum... read more

Antibiotic Treatment of Hospital-acquired Pneumonia

Should We Stop Trending Lactate in Septic Shock?

There may be a tendency to cement guideline recommendations into our collective minds as inalienable and sacrosanct – as if carved onto stone tablets and brought down to us from the heights of Mount Sinai. Thoughtful medicine,... read more

Should We Stop Trending Lactate in Septic Shock?

Implementing Early Mobilization in the ICU

The use of a quality improvement appraisal tool can help identify high quality projects when planning a similar mobility program. Even though projects were conducted in a variety of intensive care unit settings, and implementation... read more

Implementing Early Mobilization in the ICU

Improved Guideline Adherence and Reduced Brain Dysfunction After a Multicenter Multifaceted Implementation of ICU Delirium Guidelines in 3,930 Patients

This large pre-post implementation study of delirium-oriented measures based on the 2013 Pain, Agitation, and Delirium guidelines showed improved health professionals’ adherence to delirium guidelines and reduced brain... read more

Improved Guideline Adherence and Reduced Brain Dysfunction After a Multicenter Multifaceted Implementation of ICU Delirium Guidelines in 3,930 Patients

Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis

The use of ultrasound guidance for thoracentesis has been associated with increased success rates and decreased complication rates. Ultrasound can be used to estimate the pleural fluid volume, characterize the effusion as... read more

Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis

Echocardiography and Lung Ultrasonography for the Assessment and Management of AHF

Echocardiography is increasingly recommended for the diagnosis and assessment of patients with severe cardiac disease, including acute heart failure (AHF). Echocardiography and LUS can assist in the rapid assessment of patients... read more

Echocardiography and Lung Ultrasonography for the Assessment and Management of AHF

Adherence to Guidelines for the Management of Donors After Brain Death

Guideline adherence to an expert panel predefined care set in brain death (DBD) donor management proved moderate leaving substantial room for improvement. An importance-performance analysis can be used to improve implementation... read more

Adherence to Guidelines for the Management of Donors After Brain Death

Delirium in Critical Illness: Haloperidol vs Ziprasidone?

Delirium is defined as an acute disorder of consciousness which can occur in up to 80% of mechanically ventilated ICU patients. This acute cognitive dysfunction is associated with prolonged hospital stay, increased mortality,... read more

Delirium in Critical Illness: Haloperidol vs Ziprasidone?

Antithrombotic Therapy for Venous Thromboembolic Disease

This JAMA Clinical Guidelines Synopsis summarizes the American College of Chest Physicians' 2016 recommendations on antithrombotic therapy for venous thromboembolism (VTE). The estimated annual incidence of VTE, defined... read more

Antithrombotic Therapy for Venous Thromboembolic Disease

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

The evidence-based ABCDEF bundle was successfully implemented in seven community hospital ICUs using an interprofessional team model to operationalize the Pain, Agitation, and Delirium guidelines. Higher bundle compliance... read more

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

Oxygen Therapy for Acutely Ill Medical Patients

It is a longstanding cultural norm to provide supplemental oxygen to sick patients regardless of their blood oxygen saturation. A recent systematic review and meta-analysis has shown that too much supplemental oxygen increases... read more

Oxygen Therapy for Acutely Ill Medical Patients

Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

The current conflicts of interest (COIs) disclosure forms of selected professional societies provide more attention to financial disclosures and COIs and less attention to detecting and managing intellectual COIs, while rarely... read more

Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

ESPEN Guideline on Clinical Nutrition in the ICU

Following the new ESPEN Standard Operating Procedures, the previous guidelines to provide best medical nutritional therapy to critically ill patients have been updated. These guidelines define who are the patients at risk,... read more

ESPEN Guideline on Clinical Nutrition in the ICU

Update on Perioperative Acute Kidney Injury

Acute kidney injury (AKI) in the perioperative period is a common complication and is associated with increased morbidity and mortality. A standard definition and staging system for AKI has been developed, incorporating a... read more

Update on Perioperative Acute Kidney Injury

Sepsis: Learn the Signs and Document

Writing in the MJA, researchers have reported the findings of a prospective cohort study comparing estimates of the incidence and mortality of sepsis using clinical diagnosis or the Australian and New Zealand Intensive Care... read more

Sepsis: Learn the Signs and Document

High Flow Nasal Oxygen for Acute Bronchiolitis?

Since bronchiolitis is a clinical diagnosis, there is no test, including viral testing and radiography, which rules it in or out (Schuh et al 2007). Sadly, despite multiple guidelines (NICE, AAP, CPS), there has also been... read more

High Flow Nasal Oxygen for Acute Bronchiolitis?