Acute Effects of Ketamine on ICP in Children With Severe TBI

Acute Effects of Ketamine on ICP in Children With Severe TBI

In this retrospective, exploratory study, intracranial pressure (ICP) did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during... read more

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial pressure (ICP) monitoring is now viewed as integral to the clinical care of many life-threatening brain insults, such as severe traumatic brain injury, subarachnoid hemorrhage, and malignant stroke. It serves... read more

Perioperative Management of Antithrombotic Therapy

Perioperative Management of Antithrombotic Therapy

Substantial new evidence has emerged since the 2012 iteration of these guidelines, especially to inform best practices for the perioperative management of patients who are receiving a VKA and may require heparin bridging,... read more

Intra-Abdominal Hypertension – Core Critical Care

Intra-Abdominal Hypertension – Core Critical Care

The most popular book at ISICEM meeting. Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality among the critically ill,... read more

General Anesthesia vs. Sedation Using Hemodynamic Control During Intraarterial Treatment for Stroke

General Anesthesia vs. Sedation Using Hemodynamic Control During Intraarterial Treatment for Stroke

The functional outcomes 3 months after endovascular treatment for stroke were similar with general anesthesia and sedation. Our results, therefore, suggest that clinicians can use either approach. Of 351 randomized patients,... read more

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute kidney injury (AKI) occurs infrequently in young patients and often raises concern for irreversible or deadly etiologies. However, AKI related to synthetic marijuana, colloquially known as K2, is an increasingly common... read more

POCUS and Digital Tomosynthesis Correlation When Used with COVID-19 Pneumonia Patients

POCUS and Digital Tomosynthesis Correlation When Used with COVID-19 Pneumonia Patients

Point-of-care ultrasound (POCUS) in primary care has good sensitivity and specificity when compared to digital tomosynthesis as regards the diagnosis of COVID-19 pneumonia in patients with the clinical suspicion of pulmonary... read more

Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients

Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients

Among nonhospitalized patients who were at high risk for Covid-19 progression, a 3-day course of remdesivir had an acceptable safety profile and resulted in an 87% lower risk of hospitalization or death than placebo. A... read more

Chlorthalidone Improves Blood Pressure Control in Advanced Chronic Kidney Disease with Hypertension

Chlorthalidone Improves Blood Pressure Control in Advanced Chronic Kidney Disease with Hypertension

Among patients with advanced chronic kidney disease and poorly controlled hypertension, chlorthalidone therapy improved blood-pressure control at 12 weeks as compared with placebo. A total of 160 patients underwent randomization,... read more

The Beta-Blocker Story: Getting It Right

The Beta-Blocker Story: Getting It Right

The idea of using beta-blockers as a treatment for ventricular fibrillation occurred to James Black over 60 years ago. He developed propranolol and cimetidine, among other pharmacologic agents, work for which he won the Nobel... read more

Optimal Follow-up After Acute Pulmonary Embolism

Optimal Follow-up After Acute Pulmonary Embolism

This position paper provides a comprehensive guide for optimal follow-up of patients with acute pulmonary embolism (PE), covering multiple relevant aspects of patient counselling. It serves as a practical guide to treating... read more

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin use is associated with a 26% raised risk of heart failure in people with at least one predisposing factor for the condition. That’s the finding of a study published today in ESC Heart Failure, a journal of the European... read more

Pulmonary Hypertension: Controversial and Emerging Topics

Pulmonary Hypertension: Controversial and Emerging Topics

This book is a clinical guide to controversial and emerging topics in pulmonary hypertension. There are multiple challenges and unanswered questions encountered by clinicians that evaluate, diagnose and treat patients with... read more

Diaphragm Dysfunction After Cardiac Surgery

Diaphragm Dysfunction After Cardiac Surgery

Symptomatic diaphragmatic dysfunction was found in 7.6% of patients after cardiac surgery. It led to an increase of respiratory complications, such as pneumonia, prolonged ventilation, and intensive care. Coronary bypass... read more