Intra-Abdominal Hypertension Is More Common Than Previously Thought

Intra-abdominal hypertension is common in both surgical and nonsurgical patients in the intensive care setting and was found to be independently associated with mortality. Despite prior reports to the contrary, intra-abdominal... read more

Intra-Abdominal Hypertension Is More Common Than Previously Thought

Association Between Continuous Hyperosmolar Therapy and Survival in Patients with TBI

Intracranial hypertension (ICH) is a major cause of death after traumatic brain injury (TBI). Continuous hyperosmolar therapy (CHT) has been proposed for the treatment of ICH, but its effectiveness is controversial. We compared... read more

Association Between Continuous Hyperosmolar Therapy and Survival in Patients with TBI

R.E.B.E.L. EM – Fluid Responsiveness and the Six Guiding Principles of Fluid Resuscitation

Fluid resuscitation is a crucial aspect of emergency and critical care. Since the advent of the concept of early goal-directed therapy, we have placed a huge emphasis on aggressive fluid resuscitation in patients with severe... read more

R.E.B.E.L. EM – Fluid Responsiveness and the Six Guiding Principles of Fluid Resuscitation

Hospitalist Tackles Chronic Disease With Food Pharmacies

Before January 2017, Rita Nguyen, MD, was "pretty much like any other academic hospitalist," she says. In the hospital, she could provide excellent care to patients, but once they were discharged, many didn't have the necessary... read more

Hospitalist Tackles Chronic Disease With Food Pharmacies

The Iatrogenic Potential of the Physician’s Words

Some of the information that physicians convey to their patients can inadvertently amplify patients' symptoms and become a source of heightened somatic distress, an effect that must be understood by physicians to ensure optimal... read more

The Iatrogenic Potential of the Physician’s Words

Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension

Borderline PH is common in patients undergoing RHC and is associated with significant comorbidities, progression to overt PH, and decreased survival. Small increases in mPAP, even at values currently considered normal, are... read more

Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension

We Need to Talk About Trauma

One of the most haunting images from my time as a junior doctor working in Hackney in the mid-1990s was in an A&E (emergency) department while we tried to resuscitate a man in his 40s. In the corner of the room stood two... read more

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome are increasingly recognized in both medical and surgical critically ill patients and are predictive of death and the development of acute kidney injury.... read more

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Lowering systolic blood pressure would save more than 100,000 lives per year, study finds

Intensive treatment to lower systolic (top number) blood pressure to below 120 would save more than 100,000 lives per year in the United States, say scientists. Two thirds of the lives saved would be men and two thirds would... read more

Lowering systolic blood pressure would save more than 100,000 lives per year, study finds

The New Blood Pressure Guidelines

The last time a major updates to the identification, classification and treatment of high blood pressure (hypertension) was 2003. Finally, the long anticipated updated comprehensive guidelines were released earlier this month... read more

The New Blood Pressure Guidelines

PAH Associated With Systemic Lupus Erythematosus

Patients with SLE-PAH have an overall 5-year survival rate of 83.9% after the Pulmonary Arterial Hypertension (PAH) diagnosis. Anti-SSA/SSB antibodies may be a risk factor for PAH, and the presence of anti-U1-RNP antibodies... read more

PAH Associated With Systemic Lupus Erythematosus

Oestrogen Inhibition Reverses PAH and Associated Metabolic Defects

Increased oestrogen is a strong epidemiological risk factor for development of pulmonary arterial hypertension (PAH) in patients, associated with metabolic defects. In addition, oestrogens drive penetrance in mice carrying... read more

Oestrogen Inhibition Reverses PAH and Associated Metabolic Defects

Risk of AKI After Intravenous Contrast Media Administration

In the largest well-controlled study of acute kidney injury (AKI) following contrast administration in the ED to date, intravenous contrast was not associated with an increased frequency of acute kidney injury. Rates of acute... read more

Risk of AKI After Intravenous Contrast Media Administration

Hypertension and Prehypertension Underdiagnosed, Undertreated in U.S. Children

Hypertension and prehypertension in children often go undiagnosed, according to a new study published in Pediatrics. The study focused on children with abnormal blood pressures across the United States.... read more

Hypertension and Prehypertension Underdiagnosed, Undertreated in U.S. Children

Variation in Monitoring and Treatment Policies for Intracranial Hypertension in TBI

Substantial variation was found regarding monitoring and treatment policies in patients with Traumatic Brain Injury (TBI) and intracranial hypertension. The results of this survey indicate a lack of consensus between European... read more

Variation in Monitoring and Treatment Policies for Intracranial Hypertension in TBI

Hyperventilation Therapy for Control of Post-Traumatic Intracranial Hypertension

During traumatic brain injury, intracranial hypertension (ICH) can become a life-threatening condition if it is not managed quickly and adequately. Physicians use therapeutic hyperventilation to reduce elevated intracranial... read more

Hyperventilation Therapy for Control of Post-Traumatic Intracranial Hypertension

Protocol-based Invasive Intracranial Pressure Monitoring in Acute Liver Failure

Acute liver failure (ALF) may result in elevated intracranial pressure (ICP). While invasive ICP monitoring (IICPM) may have a role in ALF management, these patients are typically coagulopathic and at risk for intracranial... read more

Protocol-based Invasive Intracranial Pressure Monitoring in Acute Liver Failure

Focus on Brain Injury – The Staircase Approach

Focus on brain injury, staircase approach for the treatment of intracranial hypertension after TBI. The development of clinical protocols based on both laboratory and clinical data has underpinned the achievements of neurocritical... read more

Focus on Brain Injury – The Staircase Approach

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality

Clinical trials have documented that lowering blood pressure reduces cardiovascular disease and premature deaths. However, the optimal target for reduction of systolic blood pressure (SBP) is uncertain. This study suggests... read more

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality

Post Intubation Hypotension: The AH SHITE mnemonic

Here is a crowd sourced approach that will allow most etiologies of post intubation hypotension to be identified: The AH SHITE mnemonic is something that you can quickly run through en route to the patient’s room, or at... read more

Post Intubation Hypotension: The AH SHITE mnemonic

Various Factors Linked to Dramatic Drop in Dementia Rates

Dementia rates have dropped dramatically over the last decade or so, according to a report published online November 21 in JAMA Internal Medicine.... read more

Various Factors Linked to Dramatic Drop in Dementia Rates