Extubation Failure Risk Prediction Model Using Bedside Ultrasound

We have established a risk prediction model for extubation failure in mechanically ventilated ICU patients. This risk model base on bedside ultrasound parameters provides valuable insights for identifying high-risk patients... read more

ECMO vs. Cardiopulmonary Bypass in Lung Transplantation

Extracorporeal membrane oxygenation (ECMO) offers perioperative advantages in lung transplantation, reducing postoperative complications, one-year mortality, and recovery time compared to CPB. However, the longer total ischemic... read more

Successful Treatment of Unilateral Pulmonary Edema as Minimally Invasive Mitral Valve Surgery Complication

We successfully treated this patient using ECMO and independent lung ventilation. Several cases have been described in the literature, but the pathogenesis and risk factors of UPE remain unclear. Management depends on... read more

Plasma Proteome Temporal Changes Associated with Sepsis Mortality

Our proteomics approach revealed significant associations between changes in the plasma proteome within the first days of sepsis and mortality as well as disease severity. We identified and characterised the underlying... read more

Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with ARDS

Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema manifested by hypoxemia and stiffness in the lungs. This study... read more

Increased Sound Levels in the Cardiac ICU Associated with Increased Heart Rate, Blood Pressure, and Sedation

Sound levels in the CICU were consistently higher than recommended. An increase in heart rate, blood pressure and sedation utilization may suggest a stress response to persistent and sudden loud sounds. Given known negative... read more

Multidisciplinary Collaborative Bundled Care Improves Outcomes in ICU Patients with Endotracheal Intubation

Multidisciplinary analgesic and sedative bundled care has demonstrated the potential to decrease restraint use in patients undergoing endotracheal intubation and mechanical ventilation, reduce the need for analgesic and sedative... read more

Corticosteroid Therapy and Pulmonary Embolism in Polytrauma Patients

Pulmonary embolism is a frequent complication in polytrauma patients. The aim of our study was to evaluate the effect of low-dose corticosteroid therapy on the incidence of pulmonary embolism (PE) in polytrauma patients.... read more

Corticosteroid Therapy and Pulmonary Embolism in Polytrauma Patients

Long-term Prevalence of PTSD Symptom in Family Members of Severe COVID-19 Patients

The prevalence of PTSD-related symptoms among family members of severely ill COVID-19 patients stayed high up to 18 months after the patients' ICU discharge. Some showed delayed onset of PTSD-related symptoms in the remote... read more

Two Biomarkers Improve CRB-65 Predictability for Death Due to Community-Acquired Pneumonia

Augmenting CRB-65 (confusion, respiratory rate, blood pressure, and age 65 or older) score with troponin T high-sensitive (TnT-hs) and procalcitonin (PCT) help to predict death or intensive care unit (ICU) admission of patients... read more

In COVID-19 Patients Supported with ECMO, ICU Mortality Is Associated with the Blood Transfusion Rate

Three-quarters of patients 3 days in these centers between July 2020 and November 2021 were included in the analysis.... read more

Predicting ICU Admission in COVID-19-Infected Pregnant Women Using Machine Learning

Routinely collected clinical and laboratory data of COVID-19-infected pregnant women may help recognize high-risk groups who are more liable for complications and more severe course or prognosis and require an ICU admission.... read more

Mini Bronchoalveolar Lavage vs. Endo-Tracheal Aspirate in Diagnosing Bacterial Pneumonia in ICU

This study supports the use of endotracheal aspirate (ETA) as a cost-effective and efficient alternative to mBAL for the diagnosis of pneumonia in intubated ICU patients, particularly in settings where resources are limited.... read more

Temporary ICU – Preparedness Concept to Increase Capacity

The temporary ICU (TICU) concept demonstrates promising potential in enhancing preparedness and maintaining critical care surge capacity during pandemics or mass casualty incidents. While shortages of medical equipment,... read more

The predictive value of LAR for determining the need for ICU admission among hospitalized patients with community-acquired pneumonia

In this study, lactate-to-albumin ratio (LAR) was found to be a good predictor of ICU admissions in hospitalized patients with CAP and was non-inferior to PSI or CURB-65 scores. LAR was found to be a good predictor of... read more

Misunderstanding Buffering in Critical Illness

It is was disappointing to read the recent review in Intensive Care Medicine on buffering in metabolic acidosis. I consider this a "pre-Copernican" approach to acid–base that does not respect basic physical–chemical principles. The... read more

Prediction of Prolonged Mechanical Ventilation in the ICU via Machine Learning

Early recognition of risk factors for prolonged mechanical ventilation (PMV) could allow for early clinical interventions, prevention of secondary complications such as nosocomial infections, and effective triage of hospital... read more

Optimizing ICU Weaning: Globalizing Personalized Weaning Strategies

this study provides compelling evidence supporting the concept of individualized weaning in the ICU. By tailoring spontaneous breathing trial (SBT) methods to match specific patient conditions, it represents an essential... read more

Effect on Norepinephrine Administration Timing on Prognosis of Septic Shock Patients

Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-h intravenous... read more

An Optimal Antibiotic Selection Framework for Sepsis Patients Using AI

In this work we present OptAB, the first completely data-driven online-updateable antibiotic selection model based on Artificial Intelligence (AI) for Sepsis patients accounting for side-effects. OptAB performs an iterative... read more

Personalized Therapies in ARDS

Acute respiratory distress syndrome (ARDS) can result from a variety of clinical conditions, causing lung injury either directly through local inflammation or indirectly because of systemic inflammatory mediators ARDS is... read more

Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment

Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing... read more

Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment