Tag: immunosuppression
Lymphocyte Count Trajectories Associated with Prognosis of Sepsis Patients
Three distinct lymphocyte trajectories were identified in sepsis patients using GBTM. Trajectory 3 was a strong predictor of 7-day and 28-day mortality, while Trajectory 1 was associated with early death. These findings... read more
Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients
The prevalence of antimicrobial de-escalation (ADE) strategy was low among intensive care unit patients. The ADE strategy demonstrated a protective effect or no adverse effect on 14-day mortality compared to the No Change... read more
Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis
Bacterial sepsis patients had early, severe inflammation, profound immune suppression, and life-threatening organ dysfunction that resolved over time; SARS-CoV-2 patients had less severe early inflammation and organ dysfunction... read more
COVID-19 Variants in Patients with Immunosuppression
Patients with immunosuppression are at risk for prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In several case reports, investigators have indicated that multimutational SARS-CoV-2... read more
RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more
Clinical Distancing of Patients with Advanced Heart Failure and Cardiac Transplantation During COVID-19
Our hospital system includes a central 825-bed, short term, acute care teaching facility where heart transplantation is performed under regulatory approval. Located 5.5 miles north of this main campus is a 107-bed cardiac... read more
Abnormalities in the Host Immune Response During Hospitalization for Sepsis
In this cohort study of 483 patients who survived hospitalization with sepsis at 12 US hospitals, 25.8% had elevated high-sensitivity C-reactive protein levels (a marker of inflammation) at 3 months, 30.2% at 6 months, and... read more
TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients
The proportion of CD127lowPD-1high T cells in patients was increased compared with healthy volunteers, although no global CD127 regulation was observed. Our results suggest that TCR activation participates in the occurrence... read more
Implanted Organs That Won’t Be Rejected
Breakthrough development uses a patient's own stomach cells, cutting the risk of an immune response to implanted organs. Israeli researchers report that they have invented the first fully personalized tissue implant, engineered... read more
Therapy Implications for Immunomodulation After Ischemic Stroke
Despite significant advances towards a better understanding of the pathophysiology of ischemic stroke-induced immunosuppression and SAP in recent years, many unanswered questions remain. The true incidence and outcomes of... read more
