Tag: infection
Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization
The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more
Single-use Endoscopy
Endoscopy is used in a variety of medical specialties ranging from gastroenterology to urology, cardiology and critical care. Traditionally, health systems have invested in reusable endoscopy equipment, but an industrywide... read more
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe... read more
RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more
OSHA releases new standard to protect front-line health workers from COVID-19
The Biden administration issued a long-awaited new workplace standard aimed at protecting front-line healthcare workers from contracting COVID-19. The emergency temporary standard, released Thursday by the Occupational... read more
COVID-19 Antibody Seropositivity Longevity Analysis
Seropositivity of IgG antibodies to both SARS-CoV-2 S and N-proteins followed a linear trend reaching approximately 90% positivity at 21 days post-index. The rate of N-protein seropositivity declined at a sharper rate,... read more
COVID-19 Infection Induces Long-lived Bone Marrow Plasma Cells
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe "Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening"... read more
Sepsis Subclasses: A Framework for Development and Interpretation
Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based... read more
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
The innate immune response is critical for recognizing and controlling infections through the release of cytokines and chemokines. However, severe pathology during some infections, including SARS-CoV-2, is driven by hyperactive... read more
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and recurrence of PCR-positive tests have been widely reported in patients after recovery from COVID-19, but some of these patients do... read more
Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination
This study found an association between vaccination with BNT162b2 in hospital employees and a decreased risk of symptomatic and asymptomatic infections with SARS-CoV-2. Limitations include the observational design; short... read more
Oral Midodrine Feasibility in Early Sepsis
This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more
The Clinical Utility of MRSA Nasal Screening to Rule Out MRSA Pneumonia
Nares screening for methicillin-resistant Staphylococcus aureus (MRSA) had a high specificity and NPV for ruling out MRSA pneumonia, particularly in cases of CAP/HCAP. Based on the NPV, MRSA nares screening is a valuable... read more
Persistent Neuropsychiatric Symptoms After COVID-19
The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of... read more
Critical Care Emergency Medicine
The groundbreaking text on critical care emergency medicine – updated with the latest evidence and recommendations. Critical Care Emergency Medicine has become the standard reference for all clinicians who wish to understand... read more
Use of Procalcitonin During the First Wave of COVID-19
A minority of patients presenting to hospital with COVID-19 have bacterial co-infection. Procalcitonin testing may help identify patients for whom antibiotics should be prescribed or withheld. This study describes the... read more
Simulated Identification of Silent COVID-19 Infections Among Children
In this simulation modeling study of a synthetic US population, in the absence of vaccine availability for children, a targeted approach to rapidly identify silent COVID-19 infections in this age group was estimated to significantly... read more
Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins
A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure. The trial... read more
10 Scientific Reasons in Support of Airborne SARS-CoV-2 Transmission
Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: "The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne... read more
Effect of Infusion Set Replacement Intervals on Catheter-related Bloodstream Infections
The optimal duration of infusion set use to prevent life-threatening catheter-related bloodstream infection (CRBSI) is unclear. We aimed to compare the effectiveness and costs of 7-day (intervention) versus 4-day (control)... read more
Co-infection in Critically Ill Patients with COVID-19
During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection,... read more
Sunlight Linked to Lower COVID-19 Deaths
Our analysis suggests that higher ambient UVA exposure is associated with lower COVID‐19 specific mortality. Further research on the mechanism may indicate novel treatments. Optimised UVA exposure may have population health... read more
