Management of Refractory COPD

Chronic obstructive pulmonary disease (COPD) is a common condition with an estimated global prevalence of almost 12 percent in adults over age 30 years [1-3]. Prior to the onset of the COVID-19 (coronavirus disease 2019)... read more

Invasive Fungal Infections in Non-neutropenic Patients

Critically ill patients, particularly those with features of immunosuppression, are susceptible to invasive fungal infections (IFI), which pose significant diagnostic and therapeutic challenges. Candida and Aspergillus,... read more

Microbial Dynamics and Pulmonary Immune Responses in COVID-19 Secondary Bacterial Pneumonia

Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated... read more

Outcomes and inflammation changes in different types of immunocompromised patients with critically ill COVID-19 admitted to ICU

Critically ill COVID-19 patients admitted to the ICU exhibit distinct clinical outcomes based on their immunosuppression status, with cancer patients facing the highest mortality rate due to variations in inflammatory responses... read more

Microbiological Profile of Hospital Infections in ICUs

Hospital-acquired infections are a serious public health problem, leading to increased morbidity and mortality among patients admitted to intensive care units, complications related to health care, as well as longer hospital... read more

Microbiological Profile of Hospital Infections in ICUs

Management of Dysregulated Immune Response in the Critically Ill

This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic... read more

Management of Dysregulated Immune Response in the Critically Ill

ICU Protocols: A Step-wise Approach, Vol I

The second edition of this highly successful book includes up-to-date notes on the step-wise management of clinical emergencies encountered in everyday intensive care units (ICU). Each thoroughly revised chapter provides... read more

ICU Protocols: A Step-wise Approach, Vol I

Thrombocytopenia and COVID-19 pairing in the ICU: Prognostic influence of thrombocytopenia in resuscitated CoViD-19 patients

CoViD-19 is a viral zoonosis caused by the coronavirus strain (SARS-CoV-2), with acute respiratory failure being its most severe manifestation. Our aim was to determine the influence of thrombocytopenia on the severity and... read more

Thrombocytopenia and COVID-19 pairing in the ICU: Prognostic influence of thrombocytopenia in resuscitated CoViD-19 patients

Distinct Immune Profiles and Clinical Outcomes in Sepsis Subphenotypes Based on Temperature Trajectories

Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro-... read more

Octenidine Bathing Effective in Preventing ICU-acquired Primary Bacteremia

EFFECT has demonstrated that octenidine is effective at preventing primary bacteremia. The emphasis lies among Gram-positive bacteria and common skin commensals. As part of a robust bundle strategy, octenidine can serve... read more

Blood Eosinophils Matter in Post-COVID-19 Pneumonia

Preliminary results showed that a eosinophil increase during hospitalization could be a potential predictor of pulmonary sequelae in surviving patients after COVID-19 pneumonia. Despite the protective role of eosinophils,... read more

Ineffectiveness of Therapeutic Plasma Exchange – Last Resort in Severe COVID-19

Patients severely infected with SARS-CoV-2 showed fluctuations in inflammatory parameters despite TPE treatment; CRS was not suppressed by TPE; and this treatment did not confer survival benefit in this patient group. A... read more

CDC Reports Rising Levels of Mycoplasma Pneumonia and RSV in Young Kids

Though the nation’s respiratory disease levels remain low overall, with COVID levels declining and little sign of a flu uptick, illnesses caused by Mycobacterium pneumoniae are increasing, especially in children, and respiratory... read more

Disease Progression Associated Cytokines in COVID-19 Patients with Deteriorating and Recovering Health Conditions

Understanding the immune response to COVID-19 is challenging due to its high variability among individuals. To identify differentially expressed cytokines between the deteriorating and recovering phases, we analyzed the Electronic... read more

The Impact of COVID-19 Pandemic on Respiratory Syncytial Virus Infection in Children

We observed a lower incidence of RSV infection and a lower rate of hospitalization for RSV during the COVID-19 pandemic. The second RSV season during the COVID-19 pandemic began earlier, lasted longer, and had a lower frequency.... read more