Tag: infection
Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus Aureus Bacteremia
The results of this study further support the importance of prompt appropriate antibiotic administration for patients with septic shock. Physicians should consider acting quickly to administer antibiotics with S. aureus... read more
Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery
Preoperative vitamin D was not associated with a composite of postoperative 30-day cardiac outcomes. However, there was a significant association between vitamin D deficiency and a composite of infectious complications and... read more
Improving Community Recognition of Sepsis Using Early Warning Scores
Introducing a community version of National Early Warning Score (NEWS) to clinical assessments in acute clinical care has shown benefits for both patients and staff, and could be disseminated to all community services across... read more
Serum Protein Changes in Pediatric Sepsis Patients Identified with an Aptamer-Based Multiplexed Proteomic Approach
The serum protein changes identified with the aptamer-based multiplexed proteomics approach used in this study can be useful to distinguish between sepsis and noninfectious systemic inflammation. A cohort of 40 children... read more
Endogenous Agmatine Metabolism Correlated with the Progression of Sepsis
Supplemental exogenous agmatine could ameliorate the lipopolysaccharide-induced systemic inflammatory responses and multiple organ injuries through the 2 receptor">imidazoline I2 receptor-ribosomal S6 kinase 2-nuclear factor-κB... read more
Cannula and Circuit Management in Peripheral ECMO
Variable practices regarding extracorporeal membrane oxygenation (ECMO) line management exist worldwide based on recommendations lacking specific ECMO content and context. This survey identified evidence gaps regarding... read more
Optimal Duration of Mechanical Ventilation and Influencing Factors Following Mandibular Distraction Osteogenesis in Infants
Mandibular distraction osteogenesis (MDO) is an effective treatment for tongue-based airway obstruction in infants with severe Pierre Robin sequence (PRS). Most infants receiving MDO require postoperative mechanical ventilation... read more
Impaired Cerebral Auto-regulation is Associated with Brain Dysfunction in Patients with Sepsis
Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD. These findings support the concept that cerebral hypoxia could contribute to the development of... read more
Time to Treatment and Mortality during Mandated Emergency Care for Sepsis
More rapid completion of a 3-hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completion of an initial bolus of intravenous fluids, were associated with lower risk-adjusted in-hospital mortality. Among... read more
Early Identification of Patients at High Risk of Streptococcus-associated Necrotizing Infections
Two simple and available upon admission clinical predictors of group A streptococcus (GAS) documentation identified among a large cohort of surgically proven necrotizing soft tissue infections (NSTIs). The results show... read more
Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients
The effect of short-term caloric restriction on gene expression in critically ill patients has not been studied. In this sub-study of the PermiT trial, we examined gene expression patterns in peripheral white blood cells... read more
Delayed Interhospital Transfer of Critically Ill Patients with Surgical Sepsis
Patients with surgical sepsis who spent more than 24 hours at an outside facility prior to transfer had greater initial illness severity, longer intervals between admission and source control, and more nosocomial infections... read more
Epidemiology of Pediatric Severe Sepsis in Main PICU Centers in Southwest China
This multicenter study demonstrates that pediatric severe sepsis is common and is a factor in the high mortality rate that is observed in PICUs in Southwest China. The mortality rate remains high; therefore, improved... read more
1-Year Outcomes in Patients with Infection-related Atrial Fibrillation
During the first year after discharge, 36% of patients with infection-related atrial fibrillation (AF) had a new hospital contact with AF. Infection-related AF was associated with increased risk of thromboembolic events... read more
Risks and Benefits of Stress Ulcer Prophylaxis for Patients With Severe Sepsis
Since the rate of gastrointestinal bleeding requiring endoscopic hemostasis is not different comparing patients with and without stress ulcer prophylaxis, and the increase in hospital-acquired pneumonia is significant, routine... read more
Climate Change, Global Warming, and Intensive Care
In the last five decades, human activities have resulted in the release of increasing quantities of carbon dioxide and other greenhouse gases, thus contributing to global climate change by additional heating of the atmosphere.... read more
Initial Therapy Affects Duration of Diarrhoea in Critically Ill Patients with Clostridioides Difficile Infection
Clostridioides Difficile Infection (CDI) further harms critically ill patients by increasing 28-day mortality and in case of prolonged diarrhoea the length of their hospital stay. Appropriate therapy should be initiated... read more
5-year Study Shows Predominance of Non-Device-Associated Pneumonia
Among more than 160,000 patients admitted to University of North Carolina hospitals during a recent 5-year period, non-device-associated, or ND, pneumonia was implicated in three of every four nosocomial pneumonia cases,... read more
Incidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent CDI Treated With Fecal Microbiota Transplantation or Antibiotics
In a propensity score–matched cohort, patients with recurrent Clostridioides difficile Infection (CDI) treated with fecal microbiota transplantation (FMT) were less likely to develop primary bloodstream infection (BSI). Of... read more
In-line Filtration of Intravenous Infusion May Reduce Organ Dysfunction of Adult Critical Patients
In-line filtration with finer 0.2 and 1.2 μm filters may be associated with less organ dysfunction and less inflammation in critically ill adult patients. Comparing fine filter vs control filter cohort, respiratory... read more
Probiotics Linked to Bloodstream Infections in ICU Patients
People carry a community of microbes in and on our bodies, and they can have a powerful influence on our physiology in many ways. Probiotics, which are live microbes, are intended to improve human health, and they sometimes... read more
Prophylactic Antibiotics After Cardiac Arrest?
This is a multicenter, double-blind, placebo-controlled trial of patients resuscitated from shockable out-of-hospital cardiac arrest. Patients were randomized to placebo versus intravenous amoxicillin-clavulanate for two... read more
