Influenza-Complicated Thromboembolism in the ICU

Influenza-complicated thromboembolism (TE) among patients with severe influenza infection in the intensive care unit (ICU) is associated with increased risk for longer- duration mechanical ventilation, longer ICU stays, and... read more

Influenza and COVID-19 Vaccination Rates Among Children Receiving Long-Term Ventilation

Children with tracheostomy and HV are at high risk of morbidity and mortality from viral ARIs. Among MyTRaCh enrollees, we found significant discrepancy between influenza and COVID-19 vaccination status. Compared with... read more

BARDA Selected Host-directed Therapeutic Candidates to Address ARDS

Biomedical Advanced Research and Development Authority (BARDA) has selected host-directed therapeutic candidates for inclusion in a phase 2 platform clinical trial to address acute respiratory distress syndrome (ARDS). Currently,... read more

Balloon-Blowing Exercise Effect on Oxygen Saturation in COVID-19 Patients

Balloon-Blowing Exercise Effect on Oxygen Saturation in COVID-19 Patients

Balloon therapy is an empirical example that patients with respiratory tract diseases can use to improve their daily care. The diaphragm and ribs are expanded and raised by the intercostal muscles, which are activated during... read more

Oxygen Support Needs in Children with RSV vs. COVID-19

Oxygen Support Needs in Children with RSV vs. COVID-19

Children with respiratory syncytial virus (RSV) had a higher risk of pneumonia, bronchiolitis, and a hospital stay of more than 4 days vs children with COVID-19 or influenza. Investigators compared demographic and clinical... read more

Metabolomic Diferences: COVID-19 vs. H1N1 Influenza in ARDS

Metabolomic Diferences: COVID-19 vs. H1N1 Influenza in ARDS

This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in acute respiratory distress syndrome (ARDS). Our findings support the concept that ARDS is associated... read more

COVID-19 Infection Triggers Profibrotic Macrophage Responses and Lung Fibrosis

COVID-19 Infection Triggers Profibrotic Macrophage Responses and Lung Fibrosis

COVID-19-induced acute respiratory distress syndrome (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyzed... read more

COVID-19 and Myocardial Infarction

COVID-19 and Myocardial Infarction

COVID-19 is a risk factor for myocardial infarction and stroke through self-controlled case series evaluation, a method that has been used to establish the risk of myocardial infarction associated with influenza infection. Regarding... read more

CCSC Encourage Flu Shots Amid COVID-19 Spread

CCSC Encourage Flu Shots Amid COVID-19 Spread

The members of the Critical Care Societies Collaborative (CCSC), which includes the American Association of Critical-Care Nurses (AACN), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and Society... read more

Thrombosis vs. Hemorrhage Rates in Patients with Severe Respiratory Failure Due to COVID-19

Thrombosis vs. Hemorrhage Rates in Patients with Severe Respiratory Failure Due to COVID-19

Significant rates of pulmonary thromboembolism and of catheter-associated deep vein thrombosis were seen in both viral infections but were greater in those requiring the use of extracorporeal membrane oxygenation in coronavirus... read more

Neutrophilic Inflammation, Immunothrombosis May Distinguish Severe COVID-19 From Influenza

Neutrophilic Inflammation, Immunothrombosis May Distinguish Severe COVID-19 From Influenza

Severe coronavirus disease 2019 (COVID-19) is associated with immunothrombotic, neutrophil-containing vessel occlusions in the lung, with neutrophils representing the primary immune cell component associated with clinical... read more

Lung Histopathology in COVID-19 as Compared to SARS and H1N1 Influenza

Lung Histopathology in COVID-19 as Compared to SARS and H1N1 Influenza

Diffuse alveolar damage (DAD) was reported in 88% of patients with COVID-19. This is similar to both H1N1 (90%) and SARS (98%). Pulmonary microthrombi was reported in 57% of patients with COVID-19. This was similar to... read more

ECMO During the Coronavirus Disease 2019 Pandemic

ECMO During the Coronavirus Disease 2019 Pandemic

In the midst of the 2009 influenza A H1N1 pandemic, clinicians turned to extracorporeal membrane oxygenation (ECMO) as a strategy to save lives. Based on the H1N1 experience, and the ECMO to Rescue Lung Injury in Severe... read more

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children

In this cohort study of 315 children with COVID-19 and 1402 children with seasonal influenza, there were no statistically significant differences in the rates of hospitalization, admission to the intensive care unit, and... read more

What’s Next for EDs in the COVID-19 Pandemic?

As of late May, most countries have falling numbers of new cases of COVID-19 and are at various stages of easing lockdown orders. This seems a good time to look back on the pandemic experience so far and at what lessons we... read more

Can COVID-19 Cause Sepsis? Coronavirus Disease and Sepsis Relationship

Can COVID-19 Cause Sepsis? Coronavirus Disease and Sepsis Relationship

On January 30th, the World Health Organization declared the 2019 Novel Coronavirus (SARS-CoV-2) a global health emergency, declaring it an "unprecedented outbreak." While the fears of a COVID-19 pandemic are legitimate,... read more

ICU Doctors Already Know How to Get COVID-19 Patients Off Ventilators Faster

ICU Doctors Already Know How to Get COVID-19 Patients Off Ventilators Faster

The coronavirus pandemic is instilling chaos that is shaking the world. When intensive care units are running out of ventilators and essential medications, and some 95,000 people die in a matter of a few months, society panics... read more