Automated vs. Conventional Ventilation in the ICU

Automated vs. Conventional Ventilation in the ICU

Automated ventilation (AV) appears to reduce the incidence and severity of blood oxygen desaturation during daily nursing procedures (DNPs) in comparison to Conventional Ventilation (CV). Of the 265 included patients,... read more

ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster

ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster

ICU Doctor Chandar Abboy and his partner came up with a way to give a voice to the voiceless. The app called “Yo Doc” allows patients on ventilators to better communicate their needs and feelings. Dr. Abboy says this... read more

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status

Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more

COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. The... read more

Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

Persistent respiratory morbidity develops in up to potentially 44% of previously healthy children less than or equal to 24 months old at follow-up after acute respiratory failure (ARF) requiring mechanical ventilation. This... read more

Presence of Genetic Variants Among Young Men With Severe COVID-19

Presence of Genetic Variants Among Young Men With Severe COVID-19

In this case series of 4 young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses. These preliminary... read more

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more

Early Prediction of ICU-Acquired Weakness

Early Prediction of ICU-Acquired Weakness

The previously developed prediction model for ICU-AW showed poor performance in a new independent multicenter validation cohort. Model updating methods improved calibration but not discrimination. The newly derived prediction... read more

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

The COVID-19 pandemic has further highlighted the usefulness of LUS in different clinical scenarios, underlining its advantages in terms of availability, operator- and patient-friendliness, relatively low cost and expertise... read more

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

Critically ill patients managed with the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle spent three more days breathing without assistance, experienced less delirium,... read more

COVID-19 and AKI

COVID-19 and AKI

Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... read more

From despair to hope: advanced therapy gives a lifeline to the sickest COVID-19 patients

From despair to hope: advanced therapy gives a lifeline to the sickest COVID-19 patients

More than two months later, that piece of paper still lies on her coffee table with four letters on it: "E-C-M-O." Irena Veronese had never heard that acronym before, but when it was first mentioned to her, it meant moving... read more

AKI in Critically Ill Patients with COVID-19

AKI in Critically Ill Patients with COVID-19

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic... read more

COVID-19: 10 Things I Wished I’d Known Some Months Ago

COVID-19: 10 Things I Wished I’d Known Some Months Ago

The COVID-19 pandemic is ongoing and spreading, affecting individuals in over 200 countries now. While COVID-19-related articles are being published every day, including guidelines of optimal clinical management, there are... read more