Safety and Efficacy of VBF in Critically Ill, Mechanically Ventilated Adults Using the PERFECT Protocol

Safety and Efficacy of VBF in Critically Ill, Mechanically Ventilated Adults Using the PERFECT Protocol

Underfeeding in critical illness is common and associated with poor outcomes. According to large prospective hospital studies, volume-based feeding (VBF) safely and effectively improves energy and protein delivery to critically... read more

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely... read more

Does high PEEP prevent alveolar cycling?

Does high PEEP prevent alveolar cycling?

Acute respiratory distress syndrome (ARDS) patients need mechanical ventilation to sustain gas exchange. Animal experiments showed that mechanical ventilation with high volume/plateau pressure and no positive end-expiratory... read more

Inter-Rater Reliability Between PICU Nurses Performing a Modification to the Glasgow Coma Scale

Inter-Rater Reliability Between PICU Nurses Performing a Modification to the Glasgow Coma Scale

The objective of this study was to estimate the inter-rater reliability of critical care nurses performing a pediatric modification of the Glasgow Coma Scale in a contemporary pediatric intensive care unit (PICU). All... read more

Management of Cardiogenic Shock

Management of Cardiogenic Shock

Cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction although mortality could be reduced from formerly ∼80% to 40–50%. In addition to percutaneous coronary intervention... read more

A Core Outcome Set for Critical Care Ventilation Trials

A Core Outcome Set for Critical Care Ventilation Trials

The main objective for this study was to obtain international consensus on a set of core outcome measures that should be recorded in all clinical trials of interventions intended to modify the duration of ventilation for... read more

Essentials of Mechanical Ventilation

Essentials of Mechanical Ventilation

The acclaimed application-based guide to adult mechanical ventilation, updated to reflect the latest topics and practice guidelines. This practical guide is written from the perspective of authors who have nearly 100 years'... read more

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

Mechanical ventilation and extracorporeal support are marginally integrated. The best environment for lung healing – complete lung collapse or protective ventilation strategy or fully open and immobile lung (all three conditions... read more

Core Outcome Measures for Critical Care Ventilation Trials

Core Outcome Measures for Critical Care Ventilation Trials

The main objective for this study was to obtain international consensus on a set of core outcome measures that should be recorded in all clinical trials of interventions intended to modify the duration of ventilation for... read more

Emergency Department Hyperoxia Associated with Increased Mortality in Mechanically Ventilated Patients

Emergency Department Hyperoxia Associated with Increased Mortality in Mechanically Ventilated Patients

Emergency Department exposure to hyperoxia is common and associated with increased mortality in mechanically ventilated patients achieving normoxia after admission. This suggests that hyperoxia in the immediate post-intubation... read more

Effect of an ICU Diary on PTSD Symptoms Among Patients Receiving Mechanical Ventilation

Effect of an ICU Diary on PTSD Symptoms Among Patients Receiving Mechanical Ventilation

Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms. Among 657 patients who were randomized completed the trial. At 3 months, significant... read more

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

Lower respiratory tract infections (LRTIs) are the leading cause of infectious disease-related deaths worldwide yet remain challenging to diagnose because of limitations in existing microbiologic tests. In critically ill... read more

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons

Variation in the accuracy of claims data for identifying sepsis and organ dysfunction limits their use for comparing hospitals' sepsis rates and outcomes. Using objective clinical data may facilitate more meaningful hospital... read more

Long-Term Outcome after Prolonged Mechanical Ventilation

Long-Term Outcome after Prolonged Mechanical Ventilation

Among patients receiving prolonged mechanical ventilation at an LTACH, 53.7% were detached from the ventilator at discharge and 1-year survival was 66.9%. Respiratory strength was well maintained, whereas peripheral strength... read more

Impact of Hypophosphatemia on Outcome of Patients in ICU

Impact of Hypophosphatemia on Outcome of Patients in ICU

Hypophosphatemia at admission is an independent risk factor for 28-day mortality in general ICU patients. The cohort included 946 patients with a median phosphate concentration of 0.77 mmol/L. Patients with hypophosphatemia... read more

Noninvasive Ventilation Through the Helmet Can Be Used For Early Mild and Moderate ARDS

Noninvasive Ventilation Through the Helmet Can Be Used For Early Mild and Moderate ARDS

Debating data have been published as regards the beneficial or deleterious effect of spontaneous breathing (SB) in comparison to controlled mechanical ventilation (CMV) during acute respiratory failure. Spontaneous breathing... read more

Post-discharge Impact of Healthcare-associated Infections in a Developing Country

Post-discharge Impact of Healthcare-associated Infections in a Developing Country

The impact of healthcare-associated infections (HCAIs) on in-hospital mortality, morbidity, length-of-stay, and costs has been extensively reported. However, few studies have focused on the follow-up of HCAI-affected subjects... read more