Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care

This book establishes the indications for the use of NIV in the context of weaning from invasive mechanical ventilation. It provides a comprehensive overview of key topics relevant for correct practical application, including... read more

Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care

Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

A recent study found that secondary bacterial pneumonia, rather than the much-discussed “cytokine storm,” is a significant factor in COVID-19-related fatalities. Almost half of the patients who required mechanical... read more

Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

Whether prone positioning of patients undergoing mechanical ventilation for COVID-19 pneumonia has benefits over supine positioning is not clear. We conducted a systematic review with meta-analysis to determine whether prone... read more

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

Significant Persistent Pain Symptoms After Critical Care Illness

Persistent pain could be a common health problem after critical illness care. Our data also suggest that there is a lack of specific follow-up after ICU discharge. Given the major consequences on patient quality of life,... read more

Significant Persistent Pain Symptoms After Critical Care Illness

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

n this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support.... read more

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

Acute Respiratory Distress Syndrome

This book covers all clinical aspects of acute respiratory distress syndrome (ARDS), from definition to treatment, focusing on the more recent recommendations and evidence-based medicine. The addressed topics are the... read more

Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome: Advances in Diagnostic Tools and Disease Management

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease.... read more

Acute Respiratory Distress Syndrome: Advances in Diagnostic Tools and Disease Management

Mechanical Ventilation from Pathophysiology to Clinical Evidence

This new book aims to give a comprehensive overview of the current challenges and solution posed to the health care professionals who need to use mechanical ventilation to treat their patients. Mechanical ventilation is... read more

Mechanical Ventilation from Pathophysiology to Clinical Evidence

Early Calorie and Protein Restriction Associated with Faster Recovery in Ventilated Patients

Compared with standard calorie and protein targets, early calorie and protein restriction did not decrease mortality but was associated with faster recovery and fewer complications. Of 3,044 patients randomly assigned... read more

Early Calorie and Protein Restriction Associated with Faster Recovery in Ventilated Patients

Strategies for Mechanical Ventilation in Patients with Brain Injury

Although direct data to guide mechanical ventilation in brain-injured patients is accumulating, the current evidence base remains limited. Ventilatory considerations in this population should be extrapolated from high-quality... read more

Strategies for Mechanical Ventilation in Patients with Brain Injury

Multifaceted Early Mobility Intervention Impact for Critically Ill Children

This study will examine whether a multifaceted strategy to optimize early mobility affects the duration of mechanical ventilation, delirium incidence, and functional outcomes in critically ill children. This study will... read more

Multifaceted Early Mobility Intervention Impact for Critically Ill Children

Methylene Blue Reduced Length of Stay in ICU

In patients with septic shock, methylene blue (MB) initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without... read more

Methylene Blue Reduced Length of Stay in ICU

Is It Time to Abandon Routine Mask Ventilation Before Intubation?

Mask ventilation in the period between induction and intubation has traditionally been used to confirm the ability to ventilate the patient while awaiting the onset of adequate neuromuscular blockade. However, recent studies... read more

Is It Time to Abandon Routine Mask Ventilation Before Intubation?

Mechanical Power: Meaning, Uses and Limitations

Ventilator-induced lung injury (VILI) carries significant attributable mortality in acute respiratory distress syndrome (ARDS). Even though all the ventilatory variables contribute to VILI, current guidelines focus almost... read more

Mechanical Power: Meaning, Uses and Limitations

Delirium Prevention in the ICU: Melatonin or Ramelteon

Melatonin modulates the circadian rhythm and has been studied as a preventive measure against the development of delirium in hospitalized patients. Such an effect may be more evident in patients admitted to the ICU, but findings... read more

Delirium Prevention in the ICU: Melatonin or Ramelteon

Ultrasound-Guided Infraclavicular Axillary Vein vs. Internal Jugular Vein Cannulation in Critically Ill Mechanically Ventilated Patients

No difference was found between the real-time ultrasound-guided out-of-plane cannulation of the IJV and the infraclavicular real-time ultrasound-guided in-plane cannulation of the AXV. Both techniques are equally efficient... read more

Ultrasound-Guided Infraclavicular Axillary Vein vs. Internal Jugular Vein Cannulation in Critically Ill Mechanically Ventilated Patients

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

The study evaluated the use of heart rate variability (HRV) to predict the outcome of patients in the ICU. HRV is a way to evaluate the cardiac effects of the autonomic nervous system, and a relation between HRV and outcome... read more

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

A Guide to Mechanical Circulatory Support: A Primer for Ventricular Assist Device (VAD) Clinicians

This unique book details a multidisciplinary approach for providers caring for the Mechanical Circulatory Support (MCS) patient. Authors discuss the history of MCS, patient selection, surgical and post-operative care, mobility... read more

A Guide to Mechanical Circulatory Support: A Primer for Ventricular Assist Device (VAD) Clinicians

Extracorporeal Membrane Oxygenation for Adults (Respiratory Medicine)

This new edition presents an evidence-based review of extracorporeal membrane oxygenation (ECMO) for adults, with a particular focus on veno-venous (VV) ECMO. Due to the dramatic impact of COVID-19, the number of institutions... read more

Extracorporeal Membrane Oxygenation for Adults (Respiratory Medicine)

Pros and Cons of Disconnecting the Ventilator During Acute Respiratory Decompensation

Disconnecting the ventilator and manual BMV should be performed in cases where device malfunction is the primary cause of decompensation. These instances are quite rare. Disadvantages of switching to BMV include loss of... read more

Pros and Cons of Disconnecting the Ventilator During Acute Respiratory Decompensation

Mechanical Ventilation: For Fun and Benefit

Illustrated and explained simply this book is for anyone that works in an intensive care unit - residents, pulmonary/critical care fellows, therapists, or nurses who wants a better understanding of mechanical ventilation. Easy... read more

Mechanical Ventilation: For Fun and Benefit

Mechanical Ventilation for the ICU Resident: A Concept Based Approach

This book is written primarily with the intent of helping medical residents understand the basics of mechanical ventilation. It is meant to be read during a one-month rotation in the ICU. It is a compilation of concepts... read more

Mechanical Ventilation for the ICU Resident: A Concept Based Approach