ICU May Be Overused for Some COPD, Acute MI, HF Patients

For patients with COPD, heart failure and myocardial infarction, who are not critically ill, a stay in the ICU may be no more beneficial than staying on a ward, according to an analysis just published in the Annals of the... read more

ICU May Be Overused for Some COPD, Acute MI, HF Patients

The effects of performance status one week before hospital admission on the outcomes of critically ill patients

PS impairment was associated with worse outcomes independently of other markers of chronic health status, particularly for patients in the medium range of severity of illness. PS impairment was moderate in 17.3 % and severe... read more

The effects of performance status one week before hospital admission on the outcomes of critically ill patients

Hemodynamic Support after Cardiac Surgery

Low cardiac output syndrome is a common complication of cardiac surgery and is associated with increased mortality. Levosimendan has been shown in small studies to be an effective therapy.... read more

Hemodynamic Support after Cardiac Surgery

Antifungal Treatment in the ICU

Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in critically ill patients. Almost 80% of IFIs are due to Candida spp., which are the third most common isolated microorganisms in the intensive... read more

Antifungal Treatment in the ICU

Electrophysiological Investigations of Peripheral Nerves and Muscles

Resting trans-membrane potential difference (Em) of skeletal muscle is correlated to the energy status of the organism: the more severe the illness, the lower the Em. In 1971, Cunningham demonstrated this association with... read more

Electrophysiological Investigations of Peripheral Nerves and Muscles

Patient-important outcomes in randomized controlled trials in critically ill patients

Patient-important outcomes are rarely primary outcomes in RCTs in critically ill patients published in 2013. Among them, mortality accounted for the majority. We promote the use of patient-important outcomes in critical care... read more

Patient-important outcomes in randomized controlled trials in critically ill patients

The Artificial Intelligence Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care

Sepsis is the third leading cause of death worldwide and the main cause of mortality in hospitals but the best treatment strategy remains uncertain. In particular, evidence suggests that current practices in the administration... read more

The Artificial Intelligence Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care

Association of Antibiotic Treatment with Outcomes in Patients Hospitalized for an Asthma Exacerbation Treated with Systemic Corticosteroids

Antibiotic therapy may be associated with a longer hospital length of stay, higher hospital cost, and similar risk of treatment failure. These results highlight the need to reduce inappropriate antibiotic prescribing among... read more

Association of Antibiotic Treatment with Outcomes in Patients Hospitalized for an Asthma Exacerbation Treated with Systemic Corticosteroids

Infectious Diseases in the Pediatric ICU

Infants and children are at high risk of acquiring infections and this is most critical on the pediatric intensive care unit, as these infections have serious effects on mortality. Infectious Diseases in the Pediatric Intensive... read more

Infectious Diseases in the Pediatric ICU

A Rare Group of White Blood Cells May Be the Secret to Prevent Sepsis

Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in maintaining health. However, these roles are not fully defined. Here we... read more

A Rare Group of White Blood Cells May Be the Secret to Prevent Sepsis

Sepsis Incidence and Mortality are Underestimated in Australian ICU Administrative Data

When compared with the reference standard — prospective clinical diagnosis — ANZICS CORE database criteria significantly underestimate the incidence of sepsis and overestimate the incidence of septic shock, and also result... read more

Sepsis Incidence and Mortality are Underestimated in Australian ICU Administrative Data

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock

Thiamine administration within 24 hours of admission in patients presenting with septic shock was associated with improved lactate clearance and a reduction in 28-day mortality compared with matched controls. Patients who... read more

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock

Early Lactate Measurements Appear to Improve Results for Septic Patients

The study by Churpek and colleagues was designed to evaluate both the frequency of urgent lactate measurements and their association with clinician interventions and mortality. An elevated lactate level means that a patient's... read more

Early Lactate Measurements Appear to Improve Results for Septic Patients

Assessment of the Safety of Discharging Select Patients Directly Home From the ICU

The discharge of select adult patients directly home from the ICU is common, and it is not associated with increased health care utilization or increased mortality. Among the 6732 patients included in the study, 2826 (42%)... read more

Assessment of the Safety of Discharging Select Patients Directly Home From the ICU

Predicting Mortality in Patients Undergoing VA-ECMO After CABG

Prediction scoring systems for coronary artery bypass grafting (CABG) patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not yet been reported. This study was designed to develop a predictive score... read more

Predicting Mortality in Patients Undergoing VA-ECMO After CABG

Artificial Intelligence in the ICU

ICU doctors are often required to analyse large volumes of complex, heterogeneous data to make life-critical decisions. Artificial Intelligence (AI), if used effectively, could reduce this burden by transforming data into... read more

Artificial Intelligence in the ICU

Shock: Roadside to Resus

If you're involved in the care of critically unwell patients then you will frequently encounter patients who are shocked. The European Society of Intensive Care Medicine defines shock as; "Life-threatening, generalized... read more

Shock: Roadside to Resus

Haloperidol for the Management of Delirium in Adult ICU Patients

Among critically ill patients, haloperidol administration compared with placebo does not significantly affect short-term mortality, incidence of delirium, ICU length of stay, or delirium or coma-free days. Additionally, there... read more

Haloperidol for the Management of Delirium in Adult ICU Patients