Real-time AI prediction for major adverse cardiac events in emergency department patients with chest pain

Real-time AI prediction for major adverse cardiac events in emergency department patients with chest pain

An artificial intelligence (AI) real-time prediction model is a promising method for assisting physicians in predicting major adverse cardiac events (MACE) in ED patients with chest pain. Further studies to evaluate the impact... read more

Sepsis and the Obesity Paradox: Size Matters in More Than One Way

Sepsis and the Obesity Paradox: Size Matters in More Than One Way

Our retrospective analysis suggests that although patient size (i.e., body mass index) is a predictor of in-hospital death among all-comers with sepsis—providing further evidence to the obesity paradox—it adds that illness... read more

Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19

Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19

Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority... read more

Steroids Confirmed to Help Severely Ill COVID-19 Patients

Steroids Confirmed to Help Severely Ill COVID-19 Patients

In patients hospitalized with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those... read more

ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland

ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland

Observed trends suggest opposing effects of ICU strain and clinical learning. Further investigation is needed to identify modifiable system factors that could alleviate strain in future epidemics and changes in clinical practice... read more

Pediatric Critical Care and COVID-19

Pediatric Critical Care and COVID-19

We provide early clinical and laboratory data about critical pediatric COVID-19, which suggest a variable disease but generally good outcomes compared with adults. Targets for research include the course of organ failure... read more

Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients

Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients

In major trauma patients, overall stomach volume deriving from food, fluids and air must be expected to be around 400–500 mL. Gastric dilation caused by air is common but not typically associated with pre-hospital airway... read more

Factors Associated With Death in Critically Ill Patients With COVID-19 in the US

Factors Associated With Death in Critically Ill Patients With COVID-19 in the US

This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more

Infectious Meningitis and Encephalitis in ICU

Infectious Meningitis and Encephalitis in ICU

Infectious meningitis and encephalitis are a major concern in ICU since they are associated with high mortality and permanent neurological injury. About 3% of central nervous system infections will be admitted in the ICU. Three... read more

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

Critically ill patients managed with the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle spent three more days breathing without assistance, experienced less delirium,... read more

5 Year Impact of ICU-acquired Neuromuscular Complications

5 Year Impact of ICU-acquired Neuromuscular Complications

ICU-acquired neuromuscular complications may impact 5-year morbidity and mortality. MRC sum score, even if slightly reduced, may affect long-term mortality, strength, functional capacity and physical function, whereas abnormal... read more

Ethnicity and Outcomes in Patients Hospitalised with COVID-19

Ethnicity and Outcomes in Patients Hospitalised with COVID-19

Preliminary studies suggest that people from Black, Asian and Minority Ethnic (BAME) backgrounds experience higher mortality from COVID-19 but the underlying reasons remain unclear. Prospective analysis of registry data... read more

Hospital-level Variation in the Development of Persistent Critical Illness

Hospital-level Variation in the Development of Persistent Critical Illness

Hospitals with higher risk- and reliability-adjusted 30-day mortality have a higher probability of developing persistent critical illness. Understanding the drivers of this variation may identify modifiable factors contributing... read more

WHO Resumes Hydroxychloroquine Study for COVID-19

The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more