Tag: mortality
Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients
The effect of short-term caloric restriction on gene expression in critically ill patients has not been studied. In this sub-study of the PermiT trial, we examined gene expression patterns in peripheral white blood cells... read more
Influence of Dyskalemia at ICU Admission and Early Dyskalemia Correction on Survival
Dyskalemia is common at ICU admission and associated with increased mortality. Occurrence of cardiac events increased with dyskalemia depth. A correction of serum potassium level by day 2 was associated with improved... read more
Effects of Sepsis on Mortality in Critically Ill Patients 2 Years After ICU Discharge
Compared with patients without sepsis, those with sepsis have higher mortality in the intensive care unit and have more pain, hospital readmissions, and functional decline within 2 years after discharge. During the study,... read more
Association Between Hospital Staffing Models and Failure to Rescue
Low failure to rescue (FTR) hospitals had significantly more staffing resources than high FTR hospitals. Although hiring additional staff may be beneficial, there remain significant financial limitations for many hospitals... read more
Epidemiology of Pediatric Severe Sepsis in Main PICU Centers in Southwest China
This multicenter study demonstrates that pediatric severe sepsis is common and is a factor in the high mortality rate that is observed in PICUs in Southwest China. The mortality rate remains high; therefore, improved... read more
Abnormalities in the Host Immune Response During Hospitalization for Sepsis
In this cohort study of 483 patients who survived hospitalization with sepsis at 12 US hospitals, 25.8% had elevated high-sensitivity C-reactive protein levels (a marker of inflammation) at 3 months, 30.2% at 6 months, and... read more
Delirium is Prevalent in Older Hospital Inpatients and Associated with Adverse Outcomes
Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The... read more
Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol
The analyses described here are those necessary to answer the trial's primary question of whether combined treatment with vitamin C, thiamine and steroids is more effective than placebo in increasing days alive and free from... read more
Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome
A serum ferritin level above 4420 ng/ml identifies in a reliable and very specific way the septic patient with macrophage activation-like syndrome (MALS). Since the recent subgroup analysis indicated a survival benefit... read more
Is Tranexamic Acid Going to CRASH the Management of TBI?
In the recent CRASH-3 randomized trial, early administration of tranexamic acid (TXA) was associated with a non-significant reduction of head injury-related 28-day mortality in patients with isolated traumatic brain injury... read more
Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury
Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers... read more
Targeted Temperature Management at 33 vs. 36 Degrees
Comatose, adult out-of-hospital cardiac arrest patients treated during the targeted temperature management 33°C period had higher odds of neurologically intact survival to hospital discharge compared with those treated during... read more
TAPSE Has Superior Predictive Value vs. RV/LV Ratio in Normotensive Patients with Acute Pulmonary Embolism
Right ventricular dysfunction (RVD) is an indicator of poor prognosis in normotensive patients with acute pulmonary embolism (APE). The aim of this study was to compare right ventricular (RV)/left ventricular (LV) ratio measured... read more
Impact of Rewarming Rate on the Mortality of Patients with Accidental Hypothermia
In this study, we found that overall, in-hospital mortality rates increase with each 0.5 °C/h decrease in rewarming rate (RR). However, judging from the results of subgroup analyses, the safest RR might differ according... read more
PICU Up! A Multicomponent Early Mobility Intervention for Critically Ill Children
Pediatric intensive units traditionally have had a culture where critically ill children are intubated and mechanically ventilated, immobilized, and highly sedated. This practice is primarily driven by a focus on safety... read more
Critical Pediatric Heart Deaths Drop by 24% at Hospitals With Cardiac ICUs
Major complications fall by 12%, time on a ventilator declines by 13% among children in the cardiac ICU at PC4 hospitals As a pediatric cardiology fellow nearly a decade ago, Michael Gaies remembers asking hospital colleagues... read more
Corticosteroids as Adjunctive Therapy in the Treatment of Influenza
Corticosteroid treatment in influenza is associated with increased mortality and hospital-acquired infection, but the evidence relates mainly to high corticosteroid doses and is of low quality with potential confounding by... read more
Triage and Flow Management in Sepsis
Septic patients had a lower priority for ICU admission and longer waiting times for an ICU vacancy than patients with other critical conditions. Overall, this implied a 2.7-fold increased risk of mortality in septic patients. The... read more
Use of Vasopressor Increases the Risk of Mortality in Traumatic Hemorrhagic Shock
Use of vasopressor for traumatic hemorrhagic shock was associated with mortality after controlling for biases (trauma severity; volume of fluid resuscitation). Among 236,698 trauma patients, 3,551 were included in the... read more
Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis
In this meta-analysis of 37 RCTs (including 9564 patients), corticosteroid treatment was significantly associated with reduced 28-day mortality, ICU mortality, and in-hospital mortality among patients with sepsis. However,... read more
Prophylactic Antibiotics After Cardiac Arrest?
This is a multicenter, double-blind, placebo-controlled trial of patients resuscitated from shockable out-of-hospital cardiac arrest. Patients were randomized to placebo versus intravenous amoxicillin-clavulanate for two... read more
Epidemiology and Costs of Sepsis in the United States
The highest burden of incidence and total costs occurred in the lowest severity sepsis cohort population. Sepsis cases not diagnosed until after admission, and those with increasing severity had a higher economic burden and... read more
