Tag: oxygenation
Safety and Feasibility of Early Physical Therapy for Patients on ECMO
With a highly trained multidisciplinary team and a focus on restoring function, it is feasible and safe to deliver early rehabilitation including standing and ambulation to patients on extracorporeal membrane oxygenation... read more
Inhaled Pulmonary Vasodilators
Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more
Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients
Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more
Thousands Who Got COVID-19 in March Are Still Sick
COVID-19 has existed for less than six months, and it is easy to forget how little we know about it. The standard view is that a minority of infected people, who are typically elderly or have preexisting health problems,... read more
The Perils of Premature Phenotyping in COVID-19
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented global healthcare challenge. Severe novel Coronavirus disease (COVID-19) pneumonia frequently causes hypoxemic respiratory failure, manifesting... read more
Prolonged Prone Position Ventilation for SARS-CoV-2 Patients is Feasible and Effective
Recently, novel coronavirus 2019 (nCOV-19) is spreading all around the world causing severe acute respiratory syndrome (SARS-CoV-2) requiring mechanical ventilation in about 5% of infected people. Prone position ventilation... read more
Predictors of Care in Persons Under Investigation for COVID-19
The healthcare burden of the coronavirus disease 2019 (COVID-19) pandemic extends beyond patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a retrospective cohort study... read more
How to Intubate the Critically Ill Like a Boss
Despite decades of experience with endotracheal intubation, we continue to find approaches to improving the process of how we intubate. In today's post we are not only going to talk about how to avoid post intubation cardiac... read more
Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation
This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more
International PICU COVID-19 Collaboration Conference Call
This episode is an international collaborative conference call hosted by Dr. Jeffrey Burns of Boston Children's Hospital and Harvard Medical School. Featured speakers are Drs. Daniel Barouch, Trevor Duke, and Robinder Khemani,... read more
Effects of Paracentesis on Hemodynamic Parameters and Respiratory Function in Critically Ill Patients
Paracentesis in critically ill patients is safe regarding hemodynamic function, renal function and intervention-related complications. Furthermore, paracentesis in critically ill and mechanically ventilated patients results... read more
Prone Positioning in Nonintubated Patients with COVID-19 and Hypoxemic Acute Respiratory Failure
In this study of patients with COVID-19 and hypoxemic respiratory failure managed outside the ICU, 63% were able to tolerate PP for more than 3 hours. However, oxygenation increased during PP in only 25% and was not sustained... read more
Sharing Data is the Key to Unlocking Remdesivir Challenges
Critical care teams should consider using remdesivir to treat patients with severe acute SARS-CoV-2 infection, but supply of the drug is limited and best practices for maximizing its effectiveness are not completely understood. The... read more
Global Effort to Collect Data on Ventilated Patients With COVID-19
As the new chair of the Asia-Pacific Chapter of the Extracorporeal Life Support Organization (ELSO), John Fraser, MBChB, PhD, began talking with the group's members last November about why influenza affects some people worse... read more
Awake Proning for COVID-19
Prone positioning improves oxygenation in spontaneous breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study. This is a retrospective case series describing 15 non-intubated patients... read more
Predicting NIV Failure in Hypoxemic Patients
Non-invasive ventilation (NIV) is applied worldwide to patients with hypoxemic respiratory failure. It is often applied as an attempt to avoid invasive mechanical ventilation. However, the application of NIV is often... read more
Here’s a Lifesaving COVID-19 Test That Costs Almost Nothing
The New York Times ran a fascinating op-ed on Monday, and I’m surprised that it hasn’t gotten more attention. Here’s the nickel summary: a hotshot ER doctor volunteered to spend time at Bellevue Hospital in Manhattan... read more
COVID-19 Pneumonia: ARDS or Not?
Even though it can meet the ARDS Berlin definition, the COVID-19 pneumonia is a specific disease with peculiar phenotypes. Its main characteristic is the dissociation between the severity of the hypoxemia and the maintenance... read more
COVID-19 Evolving Indications for Intubation
Hypoxemia and tachypnea should not be the sole indications for intubation, but rather a complete clinical assessment including work of breathing, mental status and increasing PaCO2 and/or acidosis. Based on experience... read more
Flow-controlled Ventilation Enhances Lung Aeration
Lung-protective ventilation for acute respiratory distress syndrome (ARDS) aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. This study... read more
Multi-Modal Characterization of the Coagulopathy Associated With ECMO
The extracorporeal membrane oxygenation(ECMO)-associated coagulopathy is a multifactorial and quickly developing syndrome. It is characterized by individual changes of coagulation parameters and platelets and is aggravated... read more
New Study on Prehospital Airway Control Trial Underway
Emory University Department of Emergency Medicine and Grady Memorial Hospital will take part in a U.S. Department of Defense-funded clinical trial to compare different ways to help people with traumatic injuries breathe. The... read more
