Bougie vs. Endotracheal Tube with Stylet on Successful Intubation

Bougie vs. Endotracheal Tube with Stylet on Successful Intubation

Among critically ill adults undergoing tracheal intubation, use of a bougie did not significantly increase the incidence of successful intubation on the first attempt compared with use of an endotracheal tube with stylet. Among... read more

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Among adult ICU patients with severe hypoxemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa). We obtained 1‑year vital status for... read more

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune... read more

Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals

Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals

Pneumonia was the leading cause of death from infectious diseases in the United States, even before the COVID-19 pandemic, and continues to be a leading cause of death. In the study, researchers at Intermountain Healthcare... read more

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia

Pneumonia is a prevalent disease with considerable morbidity and mortality among the pediatric population. Early diagnosis and swift commencement of the correct treatment are vital for a favorable clinical outcome. Along... read more

Pediatric Pneumonia Research Priorities in the Context of COVID-19

Pediatric Pneumonia Research Priorities in the Context of COVID-19

Operational research on health system capacities, and evaluating optimized delivery of existing treatments, diagnostics and case management approaches are needed. This list should act as a catalyst for collaborative research,... read more

POCUS and Digital Tomosynthesis Correlation When Used with COVID-19 Pneumonia Patients

POCUS and Digital Tomosynthesis Correlation When Used with COVID-19 Pneumonia Patients

Point-of-care ultrasound (POCUS) in primary care has good sensitivity and specificity when compared to digital tomosynthesis as regards the diagnosis of COVID-19 pneumonia in patients with the clinical suspicion of pulmonary... read more

Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China

Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China

There was nonlinear relationship between fluid balance and all three tiers of ventilator-associated event, with an fluid balance between –1 and 0 L corresponding to the lowest risk. Positive but not negative fluid balance... read more

Critical COVID-19 Pneumonia Determinants

Critical COVID-19 Pneumonia Determinants

SARS-CoV-2 infection is benign in most individuals but, in approx. 10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years... read more

The Value of Echocardiography Combined with Lung Ultrasound to Evaluate COVID-19 Pneumonia

The Value of Echocardiography Combined with Lung Ultrasound to Evaluate COVID-19 Pneumonia

In COVID-19 pneumonia patients, the pulmonary arterial pressure and LUS are positively correlated. For those who are unable to be transferred or relocated, the pulmonary arterial pressure may be measured to reflect the degree... read more

High-Dose Dexamethasone vs. Tocilizumab in COVID-19 Pneumonia

High-Dose Dexamethasone vs. Tocilizumab in COVID-19 Pneumonia

Our study findings discourage the use of high doses of dexamethasone in the management of moderate to severe COVID-19 ARDS. The routine use of such high doses to mitigate the inflammatory cytokine storm in these patients... read more

Risk Factors for Severe COVID-19 Outcomes Among Adults Who Completed a Primary COVID-19 Vaccination

Risk Factors for Severe COVID-19 Outcomes Among Adults Who Completed a Primary COVID-19 Vaccination

In this analysis of data from 465 U.S. health care facilities, severe COVID-19 outcomes (i.e., respiratory failure, ICU admission, or death) were rare among adults aged ≥18 years after primary vaccination. These findings... read more

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission... read more

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Although corticosteroid administration has been associated with improved outcomes in severe COVID-19 pneumonia, their ideal use remains undefined with a "one size fits all" approach used, irrespective of the individual inflammatory... read more

Mesenchymal Stem/Stromal Cell-based Therapies for Severe Viral Pneumonia

Mesenchymal Stem/Stromal Cell-based Therapies for Severe Viral Pneumonia

Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited... read more

Atlas of Chest Imaging in COVID-19 Patients

Atlas of Chest Imaging in COVID-19 Patients

This book presents X-ray and CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia in early, progressive, critical, and recover stage. It starts with a general review of CT features of new coronavirus... read more