Hypercalcemia of Immobility in Critically Ill Patients

Significant hypercalcemia can occur in intensive care unit (ICU) patients. Immobilization hypercalcemia has been infrequently reported after ICU admission. Patients, therefore, usually require extensive workup to rule out... read more

Hypercalcemia of Immobility in Critically Ill Patients

COVID-19 Critical and Intensive Care Medicine Essentials

This book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological... read more

COVID-19 Critical and Intensive Care Medicine Essentials

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient... read more

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Oxygen Support Needs in Children with RSV vs. COVID-19

Children with respiratory syncytial virus (RSV) had a higher risk of pneumonia, bronchiolitis, and a hospital stay of more than 4 days vs children with COVID-19 or influenza. Investigators compared demographic and clinical... read more

Oxygen Support Needs in Children with RSV vs. COVID-19

The Song of the Cell: An Exploration of Medicine and the New Human

In the late 1600s, Mukherjee sets the stage for an extraordinary tale. It revolves around two notable individuals: Robert Hooke, a renowned English polymath, and Antonie van Leeuwenhoek, an eccentric Dutch cloth-merchant.... read more

The Song of the Cell: An Exploration of Medicine and the New Human

Comparison of ETA and BALF mNGS in Severe Pneumonia

Our study showed that some differences in the microbiological diagnosis via endotracheal aspirate (ETA) mNGS and bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) appear to exist. Clinicians... read more

Comparison of ETA and BALF mNGS in Severe Pneumonia

Rapid Sepsis Tests Using Magnetic Nanoparticles

Qun Ren, an Empa researcher, and her team are currently developing a diagnostic procedure that can rapidly detect life-threatening blood poisoning caused by staphylococcus bacteria. Staphylococcal sepsis is fatal in up... read more

Rapid Sepsis Tests Using Magnetic Nanoparticles

Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

A recent study found that secondary bacterial pneumonia, rather than the much-discussed “cytokine storm,” is a significant factor in COVID-19-related fatalities. Almost half of the patients who required mechanical... read more

Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

Whether prone positioning of patients undergoing mechanical ventilation for COVID-19 pneumonia has benefits over supine positioning is not clear. We conducted a systematic review with meta-analysis to determine whether prone... read more

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

AHRQ Errors Report was “Outright Unconscionable”

Headlines this winter screamed the bad news: Emergency physicians are literally killing people! "As many as 250,000 people die every year because they are misdiagnosed in the emergency room, with doctors failing to identify... read more

AHRQ Errors Report was “Outright Unconscionable”

Postextubation Complications vs. Positive-Pressure Suctioning Techniques

Currently available studies that compared post-extubation complications in subjects managed with the positive-pressure and suctioning techniques were summarized. Further high-quality studies with a robust study design and... read more

Postextubation Complications vs. Positive-Pressure Suctioning Techniques

Regular Old Pneumonia Treatment Just Got Better

In 2020, COVID-19 pneumonia became so common that "old-fashioned" bacterial pneumonia suddenly seemed rare. They look very different on x-ray. See if you can spot the differences. A new study from France tipped the scales... read more

Regular Old Pneumonia Treatment Just Got Better

Hydrocortisone in Severe Community-Acquired Pneumonia

Among patients with severe community-acquired pneumonia being treated in the ICU, those who received hydrocortisone had a lower risk of death by day 28 than those who received placebo. A total of 800 patients had undergone... read more

Hydrocortisone in Severe Community-Acquired Pneumonia

Effect of ICU Quality Control Indicators on VAP Incidence Rate and Mortality

This study highlights the association between the ICU quality control (QC) factors and ventilator-associated pneumonia (VAP) incidence rate and mortality. The process factors rather than the structural factors need to be... read more

Effect of ICU Quality Control Indicators on VAP Incidence Rate and Mortality

Continuous Positive Airway Pressure Usage During COVID-19

We confirm that use of early continuous positive airway pressure (CPAP) with high-flow output combined with an "ad hoc" algorithm to inform the decision to intubate is a valid and safe strategy for respiratory support in... read more

Continuous Positive Airway Pressure Usage During COVID-19

Postoperative Pulmonary Complications in the ENIGMA II Trial

Respiratory complications remain among the most common and serious adverse outcomes of major surgery. In the Australian and New Zealand Audit of Surgical Mortality, postoperative pneumonia accounted for 44% of infective... read more

Postoperative Pulmonary Complications in the ENIGMA II Trial

Bougie vs. Endotracheal Tube with Stylet on Successful Intubation

Among critically ill adults undergoing tracheal intubation, use of a bougie did not significantly increase the incidence of successful intubation on the first attempt compared with use of an endotracheal tube with stylet. Among... read more

Bougie vs. Endotracheal Tube with Stylet on Successful Intubation

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Among adult ICU patients with severe hypoxemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa). We obtained 1‑year vital status for... read more

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune... read more

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals

Pneumonia was the leading cause of death from infectious diseases in the United States, even before the COVID-19 pandemic, and continues to be a leading cause of death. In the study, researchers at Intermountain Healthcare... read more

Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia

Pneumonia is a prevalent disease with considerable morbidity and mortality among the pediatric population. Early diagnosis and swift commencement of the correct treatment are vital for a favorable clinical outcome. Along... read more

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia