Non-invasive Respiratory Support and P-SILI in COVID-19

Non-invasive Respiratory Support and P-SILI in COVID-19

Coronavirus disease 2019 (COVID-19) pneumonia is associated with hypoxemic respiratory failure, ranging from mild to severe. Due to the worldwide shortage of intensive care unit beds, a relatively high number of patients... read more

The Clinical Utility of MRSA Nasal Screening to Rule Out MRSA Pneumonia

The Clinical Utility of MRSA Nasal Screening to Rule Out MRSA Pneumonia

Nares screening for methicillin-resistant Staphylococcus aureus (MRSA) had a high specificity and NPV for ruling out MRSA pneumonia, particularly in cases of CAP/HCAP. Based on the NPV, MRSA nares screening is a valuable... read more

POCUS of the Heart and Lungs in Patients with Respiratory Failure

POCUS of the Heart and Lungs in Patients with Respiratory Failure

Point-of-care ultrasound (POCUS) is a focus oriented tool for differentiating among cardiopulmonary diseases. Its value in the hands of emergency physicians, with various ultrasound experience, remains uncertain. We tested... read more

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute... read more

Validation of Sputum Gram Stain for Treatment of CAP and HCAP

Validation of Sputum Gram Stain for Treatment of CAP and HCAP

The usefulness of sputum Gram stain in patients with community-acquired pneumonia (CAP) is controversial. There has been no study to evaluate the diagnostic value of this method in patients with healthcare-associated pneumonia... read more

Post‑COVID‑19 Syndrome in Outpatients

Post‑COVID‑19 Syndrome in Outpatients

Background Some patients experience long-term symptoms after COVID-19, but data on outpatients with mild-to-moderate COVID-19 are scarce. Objective To describe persisting symptoms more than 3 months after infection in PCR-confirmed... read more

Optimal Needle Position for Decompression of Tension Pneumothorax

Optimal Needle Position for Decompression of Tension Pneumothorax

Tension Pneumothorax (TP) can occur as a potentially life-threatening complication of chest trauma. With the risk of respiratory and cardiac arrest, an immediate temporizing intervention for this condition is required by... read more

Outcomes of Patients with COVID-19 and Relationship with Lung Ultrasound Signs

Outcomes of Patients with COVID-19 and Relationship with Lung Ultrasound Signs

In patients with COVID-19 pneumonia, Lung Ultrasound Signs (LUS) signs, including the aeration score, were related to respiratory and systemic symptoms 1 month after ultrasound screening examination. In these patients, a... read more

A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

The use of corticosteroids in patients with pneumonia secondary to COVID-19 has been a controversially hot topic, particularly early on in the pandemic. Prior evidence seen in Severe Acute Respiratory Syndrome (SARS) and... read more

Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections

Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections

Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which... read more

24-Hour Esophageal pH Measurement in Mechanically Ventilated Children

24-Hour Esophageal pH Measurement in Mechanically Ventilated Children

The current study shows high incidence of gastroesophageal reflux on 24-hour esophageal pH-metry in mechanically ventilated children with medical diagnoses. The significance of this finding and its impact on ventilator-associated... read more

Early Tracheotomy Shortens ICU Stay and Lowers Risk of VAP

Early Tracheotomy Shortens ICU Stay and Lowers Risk of VAP

Compared with late tracheotomy, early intervention was associated with lower ventilator-associated pneumonia (VAP) rates and shorter durations of mechanical ventilation and ICU stay, but not with reduced short-term, all-cause... read more

Can Ultrasound Predict Histologic Pattern of Lung Injury in COVID‑19 patient?

Can Ultrasound Predict Histologic Pattern of Lung Injury in COVID‑19 patient?

We have read with great interest the study by de Almeida Monteiro et al. recently published in Intensive Care Medicine, where authors studied the relationship between histopathological data and lung ultrasonographic (LUS)... read more

Endemic COVID-19 Needs Novel, Prognostic Tests to Predict Severity and Progression

Endemic COVID-19 Needs Novel, Prognostic Tests to Predict Severity and Progression

COVID-19 has evolved into a long-term population health problem that requires new types of diagnostics. Diagnostic developers, therefore, are called on to expand their developmental focus to include novel tests to predict... read more

Prophylaxis for Pneumocystis Pneumonia in non‐HIV Immunocompromised Patients

Prophylaxis for Pneumocystis Pneumonia in non‐HIV Immunocompromised Patients

Our review shows that TMP/SMX prophylaxis is highly effective for prevention of Prophylaxis for Pneumocystis Pneumonia (PCP) in patients with hematological malignancies, bone marrow transplantation and solid organ transplantation,... read more

Medical oxygen crisis: a belated COVID-19 response

Medical oxygen crisis: a belated COVID-19 response

More than a year into the pandemic, global health agencies have set up a taskforce to address the vast unmet demand for medical oxygen. The global pandemic response mechanism, the Access to COVID-19 Tools Accelerator (ACT-A),... read more

Efficacy of Serum Angiotensin II Levels in Prognosis of Patients with COVID-19

Efficacy of Serum Angiotensin II Levels in Prognosis of Patients with COVID-19

The serum angiotensin II levels decrease significantly in patients with coronavirus disease 2019, and this decrease is correlated with lung damage. There was no statistical significance between the serum angiotensin II... read more