Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients

Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more

Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients

Innovative Approaches to Patient Rehabilitation Maximize COVID-19 Recovery

People hospitalized with COVID-19 can experience debilitating physical changes — extreme fatigue, difficulty breathing and muscle weakness, says April Pruski, M.D., a Johns Hopkins physiatrist (a medical doctor who specializes... read more

Innovative Approaches to Patient Rehabilitation Maximize COVID-19 Recovery

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Recovering from COVID-19: Post Viral-fatigue and Conserving Energy

Rehabilitation is fast becoming the new priority in dealing with the impact of this pandemic and is crucial for people recovering from COVID-19 infection. Royal College of Occupational Therapists published three guides... read more

Recovering from COVID-19: Post Viral-fatigue and Conserving Energy

Humanizing the ICU Experience with Enhanced Communication

Decisions to limit therapy (DTLT) are routine for ICU physicians. Although breaking bad news is one of the most difficult tasks clinicians face, ongoing communication is even more crucial as families (not necessary following... read more

Humanizing the ICU Experience with Enhanced Communication

Impact of Protocolized Diuresis for De-resuscitation in the ICU

Using a diuresis protocol for volume de-resuscitation, we demonstrated a significant decrease in net cumulative fluid balance at 72 h following shock resolution, with potential benefit on clinical outcomes including renal... read more

Impact of Protocolized Diuresis for De-resuscitation in the ICU

Standardized EEG Analysis to Reduce the Uncertainty of Outcome Prognostication After Cardiac Arrest

In the majority of comatose cardiac arrest (CA) patients, the outcome remains indeterminate after application of ERC/ESICM prognostication algorithm. Standardized EEG background analysis enables accurate prediction of both... read more

Standardized EEG Analysis to Reduce the Uncertainty of Outcome Prognostication After Cardiac Arrest

When Exercise Comes to the Hospital’s ICUs

Even short hospital ICU stays can cause lasting problems for patients. Can early mobility and exercise help? Apna Kudchadkar still remembers the morning in 2010 that shaped the trajectory of her scientific research. She... read more

When Exercise Comes to the Hospital’s ICUs

Automated Anesthetic Management Outperforms Manual Control and May Have an Impact on Delayed Neurocognitive Recovery

Among older, non-frail patients undergoing moderate and high-risk noncardiac surgery, an automated anesthetic management using the combination of three independent closed-loop systems outperformed manual control and may have... read more

Automated Anesthetic Management Outperforms Manual Control and May Have an Impact on Delayed Neurocognitive Recovery

Prognostic Value of Spreading Depolarizations in Patients With Severe TBI

In this cohort study of patients with acute brain trauma, spreading depolarizations were predominant but heterogeneous and independently associated with poor neurologic recovery. Monitoring the occurrence of spreading depolarizations... read more

Prognostic Value of Spreading Depolarizations in Patients With Severe TBI

Tailoring Nutrition Therapy to Illness and Recovery

Without doubt, in medicine as in life, one size does not fit all. We do not administer the same drug or dose to every patient at all times, so why then would we live under the illusion that we should give the same nutrition... read more

Tailoring Nutrition Therapy to Illness and Recovery

Left Ventricular Wall Findings in Non-electrocardiography-gated CE-CT After ECPR

Few studies have reported left ventricular wall findings in contrast-enhanced computed tomography (CE-CT) after extracorporeal cardiopulmonary resuscitation (ECPR). This study examined left ventricular wall CE-CT findings... read more

Left Ventricular Wall Findings in Non-electrocardiography-gated CE-CT After ECPR

Long-term Cognitive Impairment After ARDS

Reducing the practical burden of cognitive recovery following critical illness depends crucially on understanding the links between brain injury and lung injury. New deficits in learning and memory, and new development... read more

Long-term Cognitive Impairment After ARDS

Pilot Randomized Trial of a Recovery Navigator Program for Survivors of Critical Illness With Problematic Alcohol Use

A Recovery Navigator intervention was feasible and acceptable for delivering high-fidelity brief interventions to ICU patients. Changes in alcohol-related problems with motivational interviewing and shared decision-making... read more

Pilot Randomized Trial of a Recovery Navigator Program for Survivors of Critical Illness With Problematic Alcohol Use

SSEP Retains its Value as Predictor of Poor Outcome Following Cardiac Arrest in the Era of Therapeutic Hypothermia

The absence of the somatosensory evoked potential (SSEP) N20 cortical wave remains one of the most reliable early prognostic tools for identifying unfavorable neurologic outcome in the evaluation of patients with severe anoxic-ischemic... read more

SSEP Retains its Value as Predictor of Poor Outcome Following Cardiac Arrest in the Era of Therapeutic Hypothermia

How To Prevent Brain-Sapping Delirium In The ICU

After an overwhelming infection sent O'Burke into five-organ failure, he also developed ICU delirium, perhaps related to heavy sedation. An ICU protocol developed at Vanderbilt University Medical Center found that getting... read more

How To Prevent Brain-Sapping Delirium In The ICU

Should fecal microbial transplantation be used in the ICU?

FMT has become an attractive option to mitigate multiple organ dysfunction in the ICU. This article discusses the physiology, rationale, early experience, and expectations for such therapy in the critically ill patient. The... read more

Should fecal microbial transplantation be used in the ICU?

The Effect of Early Mobilization in Critically Ill Patients

This study indicated that early mobilization was effective in preventing the occurrence of ICU-AW, shortening the length of ICU and hospital stay, and improving the functional mobility. However, it had no effect on the ICU... read more

The Effect of Early Mobilization in Critically Ill Patients

Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus

Patients with refractory status epilepticus (RSE) treated with continuous intravenous anesthetic drugs (cIVADs) may benefit from early initiation of such therapy. When cIVADs are applied in RSE, prescribing them early... read more

Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus

Early Detection and Monitoring of Cerebral Ischemia Using Calcium-Responsive MRI Probes

The duration of cerebral ischemia is a key factor in determining the severity of brain damage and the course of action. Thus, an accurate and timely observation of the ischemic process is highly critical. Here we present... read more

Early Detection and Monitoring of Cerebral Ischemia Using Calcium-Responsive MRI Probes

Improving Outcomes for ICU Survivors

In response to the many challenges faced by ICU survivors today, there has been an increasing need to relieve this burden. Despite that many clinical trials have been implemented to find new strategies, post-intensive care... read more

Improving Outcomes for ICU Survivors