Tag: research
NIH-convened Expert Panel Proposes Standardized Definition of Placental COVID-19 Infection
A panel of experts convened by the National Institutes of Health has recommended standardized criteria to define infection of the placenta with SARS-CoV-2, the virus that causes COVID-19. The panel also offers guidance... read more
Imputation Strategies for Missing Baseline Neurological Assessment Covariates After TBI
Statistical models for outcome prediction are central to traumatic brain injury (TBI) research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models... read more
COVID-19, Online Shaming, and Health-care Professionals
Stigma and shame have been features of past pandemics. The stigma associated with disease can be experienced as shame by those who spread it. In almost all human cultures, there is shame attached to being “contaminated”,... read more
Progressive Increase in Virulence of COVID-19 Variants
The progressive increase in transmissibility and virulence of SARS-CoV-2 VOCs will result in a significantly larger, and more deadly, pandemic than would have occurred in the absence of variants of concern (VOC) emergence. The... read more
Artificial Intelligence Hold Promise in the ICU
In a 2018 article entitled “Human Cognitive Limitations”, the University of Utah's Alan Morris estimated the number of variables an intensivist has to take into account for a patient on mechanical ventilation. He... read more
COVID-19: a boost for intensive care authorship?
Almost 180 million cases of COVID-19 have been diagnosed, with almost 4.000.000 deaths. Since this pandemic had unprecedented worldwide healthcare and socio-economic effects, the scientific world is under exceptional pressure... read more
Effects of Early Mobilization on the Prognosis of Critically Ill Patients
Early mobilization was effective in enhancing the recovery of critically ill patients, but more large-scale, multicenter randomized controlled trials are required to further confirm these findings. A total of 39 articles... read more
Multimorbidity on Long-Term Outcomes Following ICU Discharge
This national cohort study has demonstrated increased resource use for critical care survivors in the year following discharge but fails to replicate past findings of increased longer-term mortality. Multimorbidity, lifestyle... read more
Do Not Attempt CPR Decisions in People Admitted with Suspected COVID-19
Early do not attempt cardiopulmonary resuscitation (DNACPR) decisions were associated with recognised predictors of adverse outcome, and were inversely associated with Asian ethnicity. Most people with an early DNACPR decision... read more
Standardized post-resuscitation damage assessment of two mechanical chest compression devices
The LUCAS 2 device shows superior resuscitation outcomes and less thoracic injuries compared to Corpuls cpr when used for experimental CPR in juvenile pigs. Researchers should be aware that different mCCDs for experimental... read more
A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients with COVID-19
Approximately, one in 20 patients hospitalized with coronavirus disease 2019 received resuscitation for an in-hospital cardiac arrest. Hospital survival after in-hospital cardiac arrest within the ICU was higher than non-ICU... read more
COVID-19 Pathophysiology: Looking Beyond Acute Disease
Careful descriptions of the clinical features of acute disease in patients infected with the novel coronavirus SARS-CoV-2 had begun to emerge before WHO declared the outbreak of COVID-19 a public health emergency of international... read more
Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage
Higher hemoglobin levels are associated with better outcome in intracerebral hemorrhage. Further research is needed to evaluate admission hemoglobin levels as both a therapeutic target and predictor of outcome. Our exposure... read more
Virtual Reality Tailored to the Needs of Post-ICU Patients
ICU-specific virtual reality appears safe and more immersive than 2D, implicating that ICU-specific virtual reality is feasible for clinical use. One should however be aware of simulator sickness-related symptoms. Future... read more
Precision Medicine in ARDS
Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for... read more
Defining Major Trauma: a Delphi Study
Based upon the output of this Delphi study, major trauma may be defined as: "Significant injury or injuries that have potential to be life-threatening or life-changing sustained from either high energy mechanisms or low energy... read more
Increasing the Reproducibility of Research Reduces the Problem of Apophenia
Apophenia, or the tendency of identifying meaningful patterns where none truly exist, is part of the human condition. We cannot surmount it, but we can strive to manage its influence. In the research context, apophenia can... read more
Effect of Neuromuscular Electrical Stimulation on the Recovery of COVID-19 Patients
The rehabilitation of patients with COVID-19 after prolonged treatment in the intensive care unit is often complex and challenging. Patients may develop a myriad of long-term multiorgan impairments, affecting the respiratory,... read more
Use of Procalcitonin During the First Wave of COVID-19
A minority of patients presenting to hospital with COVID-19 have bacterial co-infection. Procalcitonin testing may help identify patients for whom antibiotics should be prescribed or withheld. This study describes the... read more
Bedside Voluntary and Evoked Forces Evaluation in ICU Patients
Around one third of intensive care unit (ICU) patients will develop severe neuromuscular alterations, known as intensive care unit-acquired weakness (ICUAW), during their stay. The diagnosis of ICUAW is difficult and often... read more
10 Scientific Reasons in Support of Airborne SARS-CoV-2 Transmission
Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: "The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne... read more
Sunlight Linked to Lower COVID-19 Deaths
Our analysis suggests that higher ambient UVA exposure is associated with lower COVID‐19 specific mortality. Further research on the mechanism may indicate novel treatments. Optimised UVA exposure may have population health... read more
