Tag: research
Prediction Model for Safe Early Discharge of Patients with an Infection
By combining readily available parameters, we developed and internally validated a prediction model for safe, early discharge among patients. Further research, preferably in a multi-center setting, is warranted to externally... read more
Human albumin solution for on-pump cardiac surgery: benefit or burden?
Deidentified individual participant data collected during the HAS FLAIR-II trial (and the data dictionary) will be shared beginning two years after article publication with no end date. These data will be available to... read more
Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients
A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more
Troponin Role in the Diagnosis and Treatment of Acute Pulmonary Embolism
Acute pulmonary embolism (APE) is a cardiovascular disease with severe consequences, wherein cardiac troponin (Tn) plays a pivotal role in diagnosis and treatment. This article reviews the various roles of Tn in managing... read more
Endothelial Activation and Microcirculatory Disorders in Sepsis and Critical Illness
The endothelium is one of the largest organs in the human body and lines the blood vessels and microcirculation of all the vital organs. As such, it functions as a massive and critical surveillance system to orchestrate recognition... read more
Prehospital Treatment of Severely Burned Patients
In the Berlin metropolitan area, paramedics and emergency physicians caring for severely burned patients need to consider long transport times. Current adherence to prehospital treatment recommendations is unsatisfactory.... read more
Ketamine for Treatment-Resistant Depression
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine... read more
BPRI and Clinical Outcomes in Patients with Septic Shock
Use of the novel dose-effect index, Blood Pressure Response Index (BPRI) was proposed to allow rapid bedside assessment of the reactivity of septic shock patients to vasoactive drugs, as isolated MAP or VIS cannot reflect... read more
AI to Predicting Mortality Risk in ICU Patients with AKI
To address the limitations of early acute kidney injury (AKI) prediction, researchers have increasingly turned to machine learning methods. However, the success of these models hinges on the selection of relevant features.... read more
Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients
Among adults receiving mechanical ventilation in the ICU, adding early in-bed Cycling to usual physiotherapy did not improve physical function at 3 days after discharge from the ICU compared with Usual physiotherapy alone.... read more
Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU
We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more
10 Reasons for Pharmacy Professionals Presence in the ICU
The momentum exists for establishing and expanding ICU pharmacy practice throughout Europe. A first step should be a White Paper, describing the roles and key priorities for ICU pharmacy professionals. Education should... read more
Screening Tools for Sepsis Identification
The authors undertook a rapid review to determine the suitability of sepsis screening tools in the emergency setting with regard to sensitivity and specificity of sepsis diagnosis. The review recognized that there is currently... read more
Acute Undifferentiated Fever with Thrombocytopenia: Clinical and Etiological Profile
Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based... read more
Sepsis Prediction Model for Determining Sepsis vs. SIRS, qSOFA, and SOFA
In this cohort study of 60,507 hospital admissions, we found that although the SPM marginally outperformed existing prediction scores in balanced accuracy for classification of sepsis, it suffers from poor timeliness, limiting... read more
Ground-breaking New AI Technology for Severe Sepsis Rapid Identification
ASEP Medical Holdings Inc. announced the ground-breaking use of artificial intelligence (AI) to rapidly identify infections at increased risk of severe sepsis. The method was developed by the Hancock Lab, under the guidance... read more
Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm
A recent study found that secondary bacterial pneumonia, rather than the much-discussed “cytokine storm,” is a significant factor in COVID-19-related fatalities. Almost half of the patients who required mechanical... read more
Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients
n this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support.... read more
Diastolic Shock Index and Septic Shock Outcome
Early recognition and resuscitation of patients in septic shock are critical skills for an emergency medicine physician. Many clinical decision-making tools have been developed and validated in their use to identify and... read more
Advances in Microbiology, Infectious Diseases and Public Health: Volume 15
This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues... read more
Methylene Blue Reduced Length of Stay in ICU
In patients with septic shock, methylene blue (MB) initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without... read more
Acute Lung Injury and Repair: Scientific Fundamentals and Methods
Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population. Several clinical disorders can initiate... read more
