Tag: research
Biomarkers of Kidney Disease
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection,... read more
Increased risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1
We started estimating the SARS-CoV-2 reproduction number in the UK using Public Health England data in March 2020, contributing to the Scientific Pandemic Influenza Modelling subgroup (SPI-M) weekly consensus estimates. In... read more
Traumatic and Ischemic Injury: Methods and Protocols
This volume focuses on procedures for the development and application of several research animal models and in vitro methods that allow researchers to gain insight into the underlying cellular, biochemical, and physiological... read more
When I Use a Word… Homeostasis and Allostasis
In most cases we do not know who first coined or even used a word. Evidence can generally be found of the earliest instance of a word in written texts, but we do not have a written history of speech nor vocal recordings earlier... read more
Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures
After withdrawal of life-sustaining measures, transient resumption of at least one cycle of cardiac activity after pulselessness occurred in 14% of patients according to retrospective analysis of waveforms; only 1% of such... read more
The fragility index in randomised controlled trials of interventions for aneurysmal subarachnoid hemorrhage
Fragility analysis supplements the p-value and risk of bias assessment in the interpretation of results of randomised controlled trials. In this systematic review we determine the fragility index (FI) and fragility quotient... read more
RECOVERY trial shows tocilizumab reduces deaths in patients hospitalised with COVID-19
The NIHR-supported RECOVERY trial has shown that tocilizumab - an anti-inflammatory rheumatoid arthritis treatment - reduces the risk of death for hospitalised patients with severe COVID-19. Researchers also found that... read more
FDA Limits Use of Convalescent Plasma as COVID-19 Treatment
The Food and Drug Administration (FDA) is scaling back its authorization of the use of convalescent blood-plasma for COVID-19 patients in an effort to guide physicians who have faced a confusing thicket of data about the... read more
Nebulised heparin for patients with or at risk of ARDS
In patients with or at risk of acute respiratory distress syndrome (ARDS), nebulised heparin did not improve self-reported performance of daily physical activities, but was well tolerated and exploratory outcomes suggest... read more
Inflammatory Response and Phenotyping in SARI From the MERS Coronavirus
One third of critically ill patients with Middle East respiratory syndrome (MERS) severe acute respiratory infection (SARI) and non-Middle East respiratory syndrome severe acute respiratory infection demonstrated a subphenotype... read more
Barriers to reporting guideline adherence in POCUS research
Although investigators and editors recognise the importance of completely reported research, reporting quality is still a core issue for point-of-care ultrasound (POCUS) research. The shared opinion held by investigators... read more
Antimicrobial‑associated Harm in Critical Care
The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial... read more
Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF
A world-leading UK-wide trial supported by NIHR is offering a pioneering cell therapy treatment for patients with acute respiratory failure (ARF) caused by COVID-19. The groundbreaking study, led by experts at Queen's... read more
Cytokine Storm Syndrome
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more
