Association of Age With Short-term and Long-term Mortality Among Patients Discharged From ICUs in France

Association of Age With Short-term and Long-term Mortality Among Patients Discharged From ICUs in France

Results of this study suggest that aging was associated with an increased risk of mortality in the 3 years after hospital discharge that included an ICU admission, with a sharp increase in those 80 years and older. However,... read more

Closed Chest Compressions in Traumatic Cardiac Arrest

Closed Chest Compressions in Traumatic Cardiac Arrest

This study demonstrated that fluid resuscitation with whole blood is significantly better than resuscitation with compressions alone or with normal saline. It further showed that there was no difference between whole blood... read more

Fluid Responsiveness in Sepsis

Fluid Responsiveness in Sepsis

Fluid challenge is a common practice in the ICU. It is one of the most important resuscitation manoeuvres of acute circulatory failure management in critically ill patients. Adequate fluid resuscitation is very important... read more

Initial Arterial pH as a Predictor of Neurologic Outcome After Out-of-hospital Cardiac Arrest

Initial Arterial pH as a Predictor of Neurologic Outcome After Out-of-hospital Cardiac Arrest

Lower pH after out-of-hospital cardiac arrest (OHCA) has been associated with worsening neurologic outcome, with ... read more

Is Pre-hospital Coagulation Management in Trauma Feasible?

Is Pre-hospital Coagulation Management in Trauma Feasible?

Coagulation management remains a formidable challenge in severely bleeding trauma patients. A strong rationale suggests starting treatment of trauma-induced coagulopathy in the pre-hospital phase. The burden of trauma is... read more

Characteristics, Management, and In-hospital Mortality Among Patients with Severe Sepsis in ICU in Japan

Characteristics, Management, and In-hospital Mortality Among Patients with Severe Sepsis in ICU in Japan

Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this study aimed... read more

Lactate-Guided Resuscitation Only Encourages Over-Resuscitation and Downstream Harms

Lactate-Guided Resuscitation Only Encourages Over-Resuscitation and Downstream Harms

The Centers for Medicare and Medicaid Services and the Surviving Sepsis Campaign both rushed to offer guidance on the appropriate management strategies for patients presenting with septic shock. In both cases, a lactate-guided... read more

Outcomes of Critically Ill Patients Who Received Cardiopulmonary Resuscitation

Outcomes of Critically Ill Patients Who Received Cardiopulmonary Resuscitation

Although overall survival of ICU patients was 15.9%, patients requiring pressors and who experienced a CPA in an ICU were half as likely to survive to discharge and to be discharged home than patients not taking pressors.... read more

The Great Debate Between Balanced and Unbalanced Crystalloids Continues

The Great Debate Between Balanced and Unbalanced Crystalloids Continues

This meta-analysis contributes very little to the current discussion mainly because of the heterogeneity of included studies. The use of fluid type in different pathologies isn't really what we need, but rather tailored use... read more

The EXACT Protocol

The EXACT Protocol

The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients. This study will determine... read more

No-Shitters, Boldface, and the Resus QRH

No-Shitters, Boldface, and the Resus QRH

In an amazing lecture; Joe Novak, ED doc and former combat aviator; spoke about the need for memorized boldface actions and then the availability of a quick reference handbook (QRH) for the next steps. But where are either... read more

Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections

Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections

In this randomized, clinical pilot trial of patients undergoing emergency surgery for thoracic aorta dissections, we found that OctaplasLG reduced glycocalyx and endothelial injury, reduced bleeding, transfusions, use of... read more

Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis

Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis

The combination of thiamine, ascorbic acid, and corticosteroids is a promising new therapy for sepsis resuscitation but currently lacks robust evidence to support its widespread use. The potential effectiveness of this medication... read more

Machine Learning for the Prediction of Volume Responsiveness in Patients with Oliguric AKI in Critical Care

Machine Learning for the Prediction of Volume Responsiveness in Patients with Oliguric AKI in Critical Care

Excess fluid balance in acute kidney injury (AKI) may be harmful, and conversely, some patients may respond to fluid challenges. This study aimed to develop a prediction model that can be used to differentiate between volume-responsive... read more

Oxygen Therapy in Acute Resuscitation

Oxygen Therapy in Acute Resuscitation

At present, evidence is lacking to support routine liberal oxygen administration in acutely ill patients and, in most circumstances, a reasonable approach is to titrate supplemental oxygen to achieve an arterial oxygen saturation... read more

Management of Refractory Vasodilatory Shock

Management of Refractory Vasodilatory Shock

Refractory shock is a lethal manifestation of cardiovascular failure defined by an inadequate hemodynamic response to high doses of vasopressor medications. Approximately 7% of critically ill patients will develop refractory... read more

Critical Care Controversies: The REBEL vs The SKEPTIC at #SMACC 2019

Critical Care Controversies: The REBEL vs The SKEPTIC at #SMACC 2019

On the last day of the last SMACC conference, Dr. Ken Milne (The SGEM) and I had a cage match debating four critical care controversies. It was all done in good fun with both of us taking our opportunities to poke a little... read more