The PICU Handbook

The PICU Handbook is a unique, portable compilation of the information essential for residents and fellows to successfully navigate the modern Level 1 and Level 2 pediatric intensive care unit (PICU). Enhanced by numerous... read more

The PICU Handbook

Textbook of Neonatal Resuscitation

Powerful resource for interactive, simulation-based teaching and learning! The Neonatal Resuscitation Program (NRP) is an educational program jointly sponsored by the American Academy of Pediatrics (AAP) and the American... read more

Textbook of Neonatal Resuscitation

Cumulative Fluid Balance During the First Three ICU Days in Septic Patients with Heart Failure

In septic patients with HFpEF, positive fluid balance of CFB-day1 might improve the prognosis of patients. However, from the second day, fluid overload was associated with poor prognosis. Therefore, we propose that on... read more

Multi-dimensional Outcomes Following ECPR

Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella) may improve short-term survival and neurological... read more

Therapeutic Hypothermia After Cardiac Arrest

Therapeutic hypothermia has emerged as a very important treatment option for patients with cardiac arrest as it provides significant protection from developing neurologic injury once the patient has been successfully resuscitated.... read more

Therapeutic Hypothermia After Cardiac Arrest

Favorable Outcomes When Using Prolonged CPR Combined with ECPR

Extracorporeal CPR (ECPR) combined with continuous renal replacement therapy (CRRT) successfully rescues a patient who experienced sudden cardiac arrest for 152 minutes. ECPR is an effective and advanced form of extracorporeal... read more

Impact of Time to Catheter-Based Therapy on Outcomes in Acute Pulmonary Embolism

Early catheter-based therapie (CBT) was associated with improved clinical outcomes in patients with acute intermediate-risk pulmonary embolism (PE). The composite PE shock score may help identify patients who will benefit... read more

Rediscovery of Acute Lung Injury in Cardiac Arrest

Systemic multi-organ injury following resuscitation from sudden cardiac arrest (CA) has long been recognized. First termed 'post-resuscitation disease' in the 1980's this systemic injury was more appropriately re-named post-CA... read more

7-day Fluid Balance Associated with Poor Outcomes

The net fluid balance in patients with sepsis 7 days following ICU administration was significantly related to mortality during hospitalization. Specifically, a 7-day fluid balance > 5,240 mL was associated with poor... read more

Lactated Ringer’s a Clear Winner for Pancreatitis Resuscitation

Pancreatitis, a common and challenging condition, presents frequently in emergency departments across the country, affecting around 34 of every 100,000 adults annually. This often-severe disease is marked by inflammation... read more

Outcomes of Older Adults With Sepsis at Admission to an ICU

Our study suggests that treating older adults with therapies recommended by the Surviving Sepsis Campaign may improve outcomes in this age group, although mortality remains high for older adults with sepsis. In addition,... read more

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

A Perspective on Post-Cardiac Arrest Syndrome

This book presents a valuable new perspective on Post-Cardiac Arrest Syndrome (PCAS), which was defined as system failure following whole-body ischemia-reperfusion injuries by the 2008 International Liaison Committee on Resuscitation.... read more

A Perspective on Post-Cardiac Arrest Syndrome

Thrombocytopenia and COVID-19 pairing in the ICU: Prognostic influence of thrombocytopenia in resuscitated CoViD-19 patients

CoViD-19 is a viral zoonosis caused by the coronavirus strain (SARS-CoV-2), with acute respiratory failure being its most severe manifestation. Our aim was to determine the influence of thrombocytopenia on the severity and... read more

Thrombocytopenia and COVID-19 pairing in the ICU: Prognostic influence of thrombocytopenia in resuscitated CoViD-19 patients

Pediatric Critical Care: A Primer for All Clinicians

Pediatric critical care is an emotionally and intellectually demanding field of medicine; however, it is at its core the discipline focused on saving and improving the lives of children affected by acute and chronic illnesses,... read more

Pediatric Critical Care: A Primer for All Clinicians

Resuscitation Arterial Waveform Quantification and Outcomes in Pediatric Patients

Providing physiologically adequate CPR for pediatric single ventricle patients palliated with Bidirectional Glenn (BDG) or Fontan physiology is challenging. Only 27% of Fontan patients survived to hospital discharge with... read more

Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension

Fluid administration is the first line treatment in intensive care unit (ICU) patients with sepsis and septic shock. While fluid boluses administration can be titrated by predicting preload dependency, the amount of other... read more

Effect of Different Shock Conditions on Mesenteric Hemodynamics

The velocity parameters of SMA Doppler ultrasound such as TAMV and PSV can reflect cardiac function. The measurements of SMA RI and PI are correlated with lactate levels, having a positive predictive value for hyperlactatemia... read more

Fluid Accumulation Syndrome in Sepsis and Septic Shock

In this review, we aimed to comprehensively summarize current literature on pathophysiology, relevance, diagnosis and treatment of fluid accumulation in patients with sepsis/septic shock. Fluid accumulation syndrome (FAS)... read more

Vasoconstriction in Septic Shock

Septic shock is associated with endothelial dysfunction leading to arterial and venous dilation, alterations in regional blood flow distribution, and microcirculatory disturbances. Fluids and vasopressors are the key... read more

Fluid Boluses May Improve CRT

Several studies have validated capillary refill time (CRT) as a marker of tissue hypoperfusion, and recent guidelines recommend CRT monitoring during septic shock resuscitation. Therefore, it is relevant to further explore... read more