Tag: sepsis
Beyond the Diaphragm: Combined Muscle Ultrasound Predicts Extubation Success in Sepsis
This prospective observational study investigated a novel approach using combined ultrasound measurements of both the diaphragm and intercostal muscles to better predict extubation outcomes in mechanically ventilated patients... read more
Most ICU Infections Miss the Mark for Classic Fever
The large number of patients being treated for infection without a high fever suggests that many could be ideal candidates for a clinical trial investigating induced hyperthermia (purposely raising body temperature) as a... read more
Sepsis Danger: High Ferritin Levels Flag Risk of Acute Liver Injury
This study used data from the MIMIC-IV database (training group) and an external hospital dataset (clinical validation group) to develop and validate a prediction model for sepsis-associated acute liver injury (SALI). The... read more
Machine Learning Can Effectively Identify Septic Patients with AKI
Causal Machine Learning (ML) framework outperformed random forest model in identifying patients with AKI and sepsis who benefit from restrictive fluid therapy. This provides a data-driven approach for personalized fluid management... read more
Sepsis Management in Resource-limited Settings
This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more
Low Phosphate Linked to Extended Hospitalization in Neonatal Sepsis
This retrospective cohort study investigated the relationship between serum phosphate levels and outcomes in neonates with sepsis using data from the Pediatric Intensive Care (PIC) database. Lower serum phosphate levels... read more
Precision Hydration: Causal Machine Learning Pinpoints Sepsis-AKI Patients Who Thrive on Less IV Fluid
The results of this study demonstrate that a causal machine learning (ML) framework can successfully identify patients with sepsis-AKI who benefit from a restrictive fluid strategy. This technology offers a promising, data-driven... read more
Sepsis’s Silent Heart Attack: Decoding and Targeting the Multi-Layered Cardiac Failure
This review synthesizes the current understanding of sepsis-induced myocardial dysfunction (SIMD), moving the field beyond supportive care toward precision therapies. While challenges remain in addressing the diverse nature... read more
Sepsis, Hemoglobin, and Harm: Transfusions Hurt When Hemoglobin Hits 10g/dL
Red Blood Cell (RBC) transfusions are common in septic patients, but this study highlights the potential for harm at higher hemoglobin (Hgb) levels. Although they may be physiologically guided up to an Hgb of 9-10g/dL, the... read more
The Double Danger: Electrolyte Chaos in AKI Drives Worse Outcomes
Electrolyte imbalances and metabolic acidosis are highly prevalent complications in Acute Kidney Injury (AKI) and are directly linked to adverse patient outcomes, including death and a greater need for intensive care. The... read more
The Antibiotic Balancing Act in ICU: Optimizing Use to Beat Resistance and Save Lives
The continuous fight against antibiotic resistance demands a routine and multidisciplinary strategy for antibiotic optimization in the ICU. Regular review and updating of these practices, based on local data on pathogens... read more
The MAP-SEPS Protocol: A New Frontier in Detecting Early Sepsis by Targeting Microcirculation
The MAP-SEPS trial is a prospective observational study designed to determine if a comprehensive, multimodal approach to peripheral perfusion monitoring can improve the early detection of sepsis and organ failure in critically... read more
Epinephrine or Norepinephrine? The Vasoactive Face-Off in Pediatric Septic Shock
This prospective observational study compared the clinical outcomes of epinephrine (adrenaline) versus norepinephrine (noradrenaline) as the initial vasoactive agent in pediatric septic shock. Study Population: 68 children... read more
Beyond SOFA: Sepsis ImmunoScore Redefines Risk Stratification for Mortality and ICU Admission
This multicenter observational study involving over 6,000 adult patients found that the Sepsis ImmunoScore, an AI-based tool, significantly outperformed six conventional clinical scores and biomarkers in predicting sepsis,... read more
Septic Shock MAP Targets: Homogeneous Response, Heterogeneous Harm
This study, which analyzed 776 patients with septic shock, found that overall, there was no significant difference in the response (no heterogeneity) to different blood pressure targets, particularly concerning the primary... read more
Why Early mHLA-DR Fails and Dynamic Monitoring is Key to Immunosuppression in Septic Shock
This 20-year study of 1,023 septic shock patients confirms that the immune marker mHLA-DR is a robust biomarker for identifying the most immunosuppressed patients who face a higher risk of death and ICU-acquired infections. The... read more
Unmasking the Burden: High IAH Prevalence, Associated Morbidity, and Novel Mortality Predictors in Critical Care
This study on 85 critically ill patients revealed a high prevalence of Intra-Abdominal Hypertension (IAH) (54.1%). Key Findings: Primary Contributors: The main factors driving IAH were intravenous (IV) fluid administration... read more
Calming the Storm: Probiotics Significantly Modulate Inflammatory Cytokines in Pediatric Sepsis
This randomized double-blind study investigated the effect of probiotic treatment in children admitted to the pediatric intensive care unit (PICU) with sepsis. Inflammatory Improvement: Probiotic therapy led to a significant... read more
A Critical Curve: Unveiling the U-Shaped Relationship Between the TG/HDL Ratio and All-Cause Mortality in Obese Sepsis
This study analyzed 938 obese sepsis patients to investigate the prognostic significance of lipid metabolism abnormalities, focusing specifically on the Triglyceride-to-HDL (TG/HDL) ratio as a predictor of all-cause mortality. Key... read more
Peripheral Perfusion-Targeted Resuscitation Improves Outcomes in Septic Shock
This study, which included 200 sepsis and septic shock patients in the emergency department, compared the effectiveness of management guided by peripheral perfusion measurements against standard care protocols. The study... read more
Rethinking Blood Pressure Goals: Why High vs. Low MAP Targets Affect Patients with Septic Shock
Based on a study of 776 patients, there's no evidence that different groups of people with septic shock respond differently to a high versus low mean arterial pressure (MAP) target. In other words, there wasn't a "one-size-fits-all"... read more
Predicting Mortality in Sepsis-Related ARDS Using Machine Learning
The application of machine learning methodologies to construct prognostic prediction models for sepsis patients complicated by ARDS, informed by the new global definition, proves to be reliable. This approach can assist clinicians... read more
