Tag: septic shock
Machine Learning Can Effectively Identify Septic Patients with AKI
Causal Machine Learning (ML) framework outperformed random forest model in identifying patients with AKI and sepsis who benefit from restrictive fluid therapy. This provides a data-driven approach for personalized fluid management... read more
Sepsis Management in Resource-limited Settings
This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more
Delirium vs. Encephalopathy: Unifying the Approach to Brain Dysfunction
Current clinical practice and research are limited by the separate, or dichotomized, use of the terms "encephalopathy" and "delirium." This separation hinders a unified approach to understanding acute brain dysfunction. Encephalopathy... read more
The Norepinephrine Salt Shaker: It’s Not the Formulation, It’s the Reporting
All commercially available norepinephrine salt formulations are clinically equivalent. The critical focus for researchers and clinicians must shift from debating the formulation to ensuring clear and standardized reporting... read more
The Antibiotic Balancing Act in ICU: Optimizing Use to Beat Resistance and Save Lives
The continuous fight against antibiotic resistance demands a routine and multidisciplinary strategy for antibiotic optimization in the ICU. Regular review and updating of these practices, based on local data on pathogens... read more
The MAP-SEPS Protocol: A New Frontier in Detecting Early Sepsis by Targeting Microcirculation
The MAP-SEPS trial is a prospective observational study designed to determine if a comprehensive, multimodal approach to peripheral perfusion monitoring can improve the early detection of sepsis and organ failure in critically... read more
Epinephrine or Norepinephrine? The Vasoactive Face-Off in Pediatric Septic Shock
This prospective observational study compared the clinical outcomes of epinephrine (adrenaline) versus norepinephrine (noradrenaline) as the initial vasoactive agent in pediatric septic shock. Study Population: 68 children... read more
Septic Shock MAP Targets: Homogeneous Response, Heterogeneous Harm
This study, which analyzed 776 patients with septic shock, found that overall, there was no significant difference in the response (no heterogeneity) to different blood pressure targets, particularly concerning the primary... read more
Why Early mHLA-DR Fails and Dynamic Monitoring is Key to Immunosuppression in Septic Shock
This 20-year study of 1,023 septic shock patients confirms that the immune marker mHLA-DR is a robust biomarker for identifying the most immunosuppressed patients who face a higher risk of death and ICU-acquired infections. The... read more
Peripheral Perfusion-Targeted Resuscitation Improves Outcomes in Septic Shock
This study, which included 200 sepsis and septic shock patients in the emergency department, compared the effectiveness of management guided by peripheral perfusion measurements against standard care protocols. The study... read more
Rethinking Blood Pressure Goals: Why High vs. Low MAP Targets Affect Patients with Septic Shock
Based on a study of 776 patients, there's no evidence that different groups of people with septic shock respond differently to a high versus low mean arterial pressure (MAP) target. In other words, there wasn't a "one-size-fits-all"... read more
Postoperative Steroids Linked to Longer Time on Ventilator
Postoperative use of systemic corticosteroids was linked to a longer duration of mechanical ventilation (MV), but it did not increase mortality or overall complications. While the study's initial analysis did not show... read more
Norepinephrine Dosing: A Historical Look at Reporting and Salt Formulations
Reporting on norepinephrine dosage has been inconsistent due to variations in how drug labels account for different salt formulations. This inconsistency creates problems in clinical practice and research by making it difficult... read more
Improving Hemodynamics in Vasoplegia Septic Shock with Adjunctive Tocilizumab
In pediatric patients with vasoplegia septic shock, adjunctive tocilizumab is associated with improved hemodynamics, shortened shock duration, and reduced mortality. IL-6 may serve as both a biomarker and therapeutic target... read more
Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients
Adult patients with septic shock, on hemodynamic support, had high-to-normal intracranial pressure (ICP). Low-dose continuous ketamine infusion as an adjunct sedative appeared to have favorable outcomes concerning ICP and... read more
Prevalence and Outcomes of Shock in Internal Medicine Patients
This retrospective observational study investigated the incidence, management, and outcomes of 125 shock patients admitted to the internal medicine department of a referral university hospital in Bangkok, Thailand, addressing... read more
Sepsis and Septic Shock: An Issue of Critical Care Clinics
Shock is caused by the decreased flow of blood to the body tissues due to circulatory system related problems. Sepsis refers to a life-threatening condition where the body causes injury to its own organs and tissues in response... read more
Impact of Esketamine vs. Remifentanil on Hemodynamics and Outcomes in Mechanically Ventilated Septic Shock
This single-center, prospective, randomized, controlled pilot study compared the hemodynamic effects and prognosis of esketamine versus remifentanil, both used in combination with propofol, for sedation and analgesia in patients... read more
Hemolysis in Septic Patients with Acute Respiratory Failure: Prognostic Implications
This study highlights the critical role of hemolysis in sepsis and acute respiratory failure, showing a strong association with organ dysfunction. Hemolysis is notably frequent, especially in patients with septic shock... read more
Aminoglycosides Impact on Survival Rate and Renal Outcomes in Patients with Urosepsis
The addition of aminoglycosides to beta-lactam therapy in critically ill patients with urosepsis did not significantly improve 30-day survival. Furthermore, aminoglycosides were not associated with worse renal outcomes.... read more
Septic Shock Metabolic Subgroups and Clinical Outcome
Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more
Sepsis: Staging and Potential Future Therapies
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more
