Successful Clearance of Persistent Staphylococcus Aureus Pneumonia Using High-dose Continuous Infusion Cefazolin

High-dose cefazolin (10 g daily), given as a continuous infusion (CI), was able to clear community-acquired methicillin-susceptible Staphylococcus aureus (MSSA) pneumonia while not exhibiting any signs of toxicity or adverse... read more

VAP in Patients with Increased Intra-abdominal Pressure

Critically ill patients with increased intra-abdominal pressure (IAP) and multidrug-resistant (MDR) ventilator-associated pneumonia (VAP) are considered a challenging patient population in every ICU setting. Patients with... read more

Prophylactic IV Antibiotics Outcomes in Patients with Acute Severe Brain Injury on Mechanical Ventilation

Among critically ill patients with acute brain injury, prophylactic IV antibiotics were associated with less VAP but not with changes in length of stay, mortality, or neurologic outcomes. Patients with structural brain... read more

Management of Pediatric Septic Shock with Electrocardiometry

Advanced hemodynamic monitoring with EC, in conjunction with clinical assessment, facilitated a restrictive fluid strategy and reduced the incidence of FO. By closely monitoring hemodynamic parameters and tailoring therapy... read more

TNF-α, PCT, IL-8, and HBP Prognostic Value Combined with APACHE II Score in Sepsis Patients

Serum TNF-α, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes. Patients were divided into sepsis and... read more

Association Between Ketamine Use and Mortality in Critically Ill Patients Receiving Mechanical Ventilation

In this retrospective study, we observed that younger patients with acute respiratory distress syndrome (ARDS) may benefit from ketamine use in terms of 14-day mortality. However, these benefits were not observed in longer-term... read more

Accurate Percutaneous Tracheal Tube Placement Using Visual-Guided Transillumination Method

The novel Illuminated Tracheal Alignment Guide (iTAG) device and technique is the first of our knowledge to test the identification of tracheostomy sites by way of laser-guided transillumination. We believe this device... read more

Predicting Renal Outcomes in Cardiac Surgery Using Intraoperative Renal Near-Infrared Spectroscopy Monitoring

This study shows that intraoperative monitoring of near-infrared spectroscopy (NIRS) values and monitoring of critical thresholds may be an important tool in predicting the development of acute renal failure (ARF) and other... read more

Peritoneal Dialysis in AKI: 20 Years of Experience at a Single Center

Peritoneal dialysis (PD) may be an effective solution for acute kidney injury (AKI) patients, allowing adequate metabolic and fluid control. Age, APACHE score, hepatorenal syndrome and dropout from PD were associated... read more

Dexmedetomidine for Sedation in Pediatric ICU

Audit shows compliance to the standards were not met. A third of the patients required higher doses of up to 2 micrograms/kg/hour of dexmedetomidine. Studies have supported the safety of higher doses of up to 2 micrograms/kg/hour.2... read more

ICU-acquired Weakness: Critical Illness Myopathy and Polyneuropathy

Critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) are significant complications in intensive care unit (ICU) patients, first identified in the late 20th century. These conditions often present... read more

Weaning Failure From Mechanical Ventilation

Ultrasound is a useful tool for identifying weaning failure from cardiovascular, diaphragmatic, respiratory, and airway origin. The strengths of our scoping review lie in its comprehensive approach to synthesizing diverse... read more

Peripheral and Respiratory Muscle Weakness and Functional Impairments in ICU Patients

This study demonstrated that patients discharged from ICU in this resource-constrained setting presented with peripheral and respiratory muscle weakness at unit discharge. Muscle weakness occurred despite a short ICU... read more

Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients

In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more

NIV Effectiveness in Critical Patients with ARF and Do Not Intubate Order

The prevalence of do-not-intubate (DNI) order was frequent in patients with acute respiratory failure (ARF) admitted to the ICU, being related to age, comorbidity, frailty and the underlying disease. non-invasive ventilation... read more

Nebulized Furosemide Effect on the Mortality of Mechanically Ventilated ARDS Adult Patients

This RCT tackles an important topic in critical care medicine, which involves a large number of critically ill patients and continues to harbor high mortality despite improvements in management. The results of the study... read more

Prophylactic NIV Effects on Weaning

The use of prophylactic non-invasive ventilation (NIV) reduced reintubation rates, ICU and hospital length of stay (LOS), and mortality. These findings support the recommendation for its use in daily practice. Rescue... read more

The Association Between Pain, Analgesia, and Delirium in Critically Ill Adults

We observed an association between pain and incident delirium among critically ill adults. Exposure to morphine or fentanyl (but no other pain medications) was associated with increased risk of delirium occurrence. From... read more

Using AI to Detect and Treat Delirium

The prevention of delirium in ICU represents a major unmet need because of its high prevalence, under-diagnosis, and independent association with adverse outcomes including higher mortality and accelerated cognitive decline.... read more

Bundle of Care Effectiveness on Tolerance of Awake-prone Positioning in ARF Patients

In the evaluated population of patients with COVID-19-related ARF, implementing a bundle-of-care strategy was associated with a longer AW-PP exposure and a reduced risk of endotracheal intubation. In this secondary analysis... read more

Major Cardiovascular Surgery-induced Metabolic Reprogramming Role in AKI

Major cardiovascular surgery, particularly with cardiopulmonary bypass (CPB), induces significant changes in protein metabolism. Patients developing postoperative acute kidney injury (AKI) exhibited specific metabolic signatures.... read more

Ventilation Practices in ABI Patients and Association with Outcomes

Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association... read more