Tag: study
Crizanlizumab use lowers rates of sickle cell crises
Patients with sickle cell disease treated with high-dose crizanlizumab experienced lower annualized rates of sickle cell crisis compared to placebo treatment, regardless of their baseline use of hydroxyurea. Those treated... read more
Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting
The results of our trials showed that prophylaxis with low-molecular-weight heparin for the 8 days after knee arthroscopy or during the full period of immobilization due to casting was not effective for the prevention of... read more
Social Media Helps Forecast Outbreak Transmission Patterns
A new study suggests then when epidemiological data are scarce, social media and Internet reports can be reliable tools for forecasting infectious disease outbreaks. Researchers at Georgia State University and the U.S. National... read more
Manufacturer guidelines fall short for endoscope reprocessing
A just-published study finds that current endoscopic manufacturer cleaning instructions for a wide range of GI, urological and respiratory devices used in diagnostic procedures still fail to protect patients from the risk... read more
Hydrocortisone Fails to Prevent Septic Shock
Hydrocortisone failed to reduce the risk of septic shock in severe sepsis patients in recent research, though its authors held out hope that a larger study could show a better result. Current guidelines recommend hydrocortisone... read more
Benefits and harms of duloxetine for treatment of stress urinary incontinence
Duloxetine was significantly better than placebo in terms of percentage change in weekly incontinence episodes (mean difference - 13.56%, 95% confidence interval [CI] -21.59% to -5.53%) and change in Incontinence Quality... read more
Transcatheter Aortic Valve Replacement in Younger Individuals
When a patient has an aortic valve that requires replacement because the native valve is diseased, 2 types of valves can be used - mechanical valves or bioprosthetic valves, also known as tissue valves. Bioprosthetic valves... read more
Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in ICU
Between Oct 31, 2011, and Dec 23, 2012, we sampled 198 health-care workers, 40 environmental locations, and 1854 patients; 1819 isolates were sequenced. Median nasal carriage rate of S aureus in health-care workers at 4-weekly... read more
Clinical Massage, Guided Imagery Show Promise as Tools to Relieve Pain, Anxiety and Insomnia for Hospitalized Patients
Clinical massage and guided imagery may have a substantial, positive impact on patients' comfort at a very low cost, according to a study published in Critical Care Nurse. Researchers with Beaumont Health System in Royal... read more
A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients
This phase II study has shown that IC43 vaccination of ventilated ICU patients produced a significant immunogenic effect. P. aeruginosa infection rates did not differ significantly between groups. In the absence of any difference... read more
Medical residents spend more time using computers than on patient interaction
At a teaching hospital in Switzerland, internal medicine residents spent an average of 52.4% and 47.9% of the day shift and evening shift, respectively, on activities indirectly related to the patient and spent 28.0% and... read more
The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families
Over the past 20 years, critical care has matured in a myriad of ways resulting in dramatically higher survival rates for our sickest patients. For millions of new survivors comes de novo suffering and disability called "the... read more
Global multicenter observational investigator initiated study
The DIANA study is a large multicenter cohort study, lead by intensive care unit experts out of the University Hospital Ghent. This investigator initiated study will collect a large amount of data from multiple centers and... read more
Effects of Video vs Direct Laryngoscopy on Successful Orotracheal Intubation in ICU Patients
Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more
Findings do not support early tracheal intubation for in-hospital cardiac arrest in adults
Decreased survival to hospital discharge was found with the initiation of tracheal intubation compared with no intubation in adult patients experiencing in-hospital cardiac arrest when the tracheal intubation was initiated... read more
SOFA score may be best to identify sepsis in the ICU
Among critically ill patients admitted to the ICU with a suspected infection, defining sepsis by an increase of two or more points in the Sequential Organ Failure Assessment (SOFA) score yielded greater prognostic accuracy... read more
Prominent clinical guidelines fall short of conflict of interest standards
Two recent clinical practice guidelines, one for cholesterol management and another for treatment of chronic hepatitis C, did not meet the Institute of Medicine's standards for limiting commercial conflicts of interest, according... read more
