Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients

The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more

PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections

Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more

Blood Glucose and Clinical Outcomes After ECC

Postoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. The study's primary outcome was the 90-day mortality,... read more

Helmet CPAP as NIV for COVID-19 Patients

The COVID-19 pandemic has challenged healthcare systems globally, highlighting the need for effective respiratory support strategies. Helmet continuous positive airway pressure (CPAP) has emerged as a potential noninvasive... read more

Tracheostomy in COVID-19 Patients

Tracheostomy is common in critically ill COVID-19 patients. In patients predicted to need a tracheostomy at some point, early, rather than late, tracheostomy might be a means to reduce the time spent in ICU. However,... read more

Pirfenidone to Prevent Fibrosis in ARDS

Pulmonary fibrosis is a major complication of the Acute Respiratory Distress Syndrome (ARDS). Pirfenidone is an approved treatment for idiopathic pulmonary fibrosis. It may attenuate ARDS-related fibrosis and decrease the... read more

Association Between Osteopontin and Apolipoprotein E gene Polymorphisms and Vancomycin-induced AKI

Individuals carrying specific genotypes of APOE (e2e3) were more prone to develop vancomycin-induced acute kidney injury (AKI), per se. This could apply to other nephrotoxic agents as well. We also observed a significant... read more

Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors

The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more

Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients

The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more

Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients

The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more

COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis

COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more

Clinical Prediction Model Development for Stages of AKI in Critically Ill Patients

Using readily available predictors in the ICU setting, we could develop a prediction model for different stages of AKI with good performance and promising clinical usefulness. Among critically ill patients, acute kidney... read more

Provocative Angiography Safety and Efficacy for Gastrointestinal Hemorrhage Localization and Treatment

This study demonstrated that provocative angiography was safe and effective for localization of intermittent or occult gastrointestinal bleeding. Overall, provocative angiography had a positivity rate of 14/40 (35 %) in this... read more

Total Bilirubin as a Marker for Hemolysis and Outcome in ARDS Patients Treated with vvECMO

Patients with acute respiratory distress syndrome (ARDS), treatment with veno-venous ECMO and a total bilirubin (tBili) plasma concentration over the threshold of 3.6 mg/dl had significantly lower chances of survival, recovery... read more

COVID-19 Omicron: Immunocompromised vs. Non-immunocompromised Patients

Immunocompromised patients admitted to the ICU due to COVID-19 during the omicron period had higher mortality than non-immunocompromised patients. Additionally, immunocompromised patients with COVID-19 had higher mortality... read more

Airflow Patterns and Adaptive Attachment Ventilation with Deflectors

A novel ventilation mode was introduced and investigated by a series of experiments under isotherm condition, focusing on elucidating the airflow patterns and characteristics associated with this mode. Semi-empirical equations... read more

Failure to Rescue in ALF

The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. In patients with acute liver failure (ALF), the concept of failure to rescue highlights the... read more

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Nebulized Long-Acting Bronchodilators to Treat ARF in an Older Patients

Although long-acting bronchodilators are not approved to treat acute respiratory failure (ARF), the older adult in this case clinically improved after three doses of revefenacin and arformoterol. Additional studies are... read more

Different Anticoagulation Regimens Effectiveness in Critically Ill Patients

This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy... read more

Methylprednisolone vs. Hydrocortisone in Septic Shock Patients

Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more

Elevated BCR Risk Factor For CHF in Critically Ill COPD Patients

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular... read more