Tag: study
Enteral Nutrition Can Be Given to Patients on Vasopressors
Most all recent studies show Enteral Nutrition (EN) can be delivered safely to patients on vasopressors. In fact, many studies show an outcome benefit of early EN (EEN) in ICU patients who are receiving vasopressors. It... read more
Early Prediction of Sepsis From Clinical Data
Diverse computational approaches predict the onset of sepsis several hours before clinical recognition, but generalizability to different hospital systems remains a challenge. A total of 104 groups from academia and industry... read more
Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery
Preoperative vitamin D was not associated with a composite of postoperative 30-day cardiac outcomes. However, there was a significant association between vitamin D deficiency and a composite of infectious complications and... read more
Serum Protein Changes in Pediatric Sepsis Patients Identified with an Aptamer-Based Multiplexed Proteomic Approach
The serum protein changes identified with the aptamer-based multiplexed proteomics approach used in this study can be useful to distinguish between sepsis and noninfectious systemic inflammation. A cohort of 40 children... read more
Cannula and Circuit Management in Peripheral ECMO
Variable practices regarding extracorporeal membrane oxygenation (ECMO) line management exist worldwide based on recommendations lacking specific ECMO content and context. This survey identified evidence gaps regarding... read more
Impaired Cerebral Auto-regulation is Associated with Brain Dysfunction in Patients with Sepsis
Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD. These findings support the concept that cerebral hypoxia could contribute to the development of... read more
Changes in Anesthetic and Postoperative Sedation-Analgesia Practice Associated With Early Extubation Following Infant Cardiac Surgery
The implementation of an early extubation clinical practice guideline resulted in a reduction in the dose of opioids and benzodiazepines without a change in volatile anesthetic agent used in the operating room. Intraoperative... read more
Early Identification of Patients at High Risk of Streptococcus-associated Necrotizing Infections
Two simple and available upon admission clinical predictors of group A streptococcus (GAS) documentation identified among a large cohort of surgically proven necrotizing soft tissue infections (NSTIs). The results show... read more
Fixing Hypernatremia: Acting Fast or Acting Slow?
This is the largest adult cohort study focusing on the neurologic complications and mortality after hypernatremia correction in critically ill adults. There wasn't any evidence that rapid correction of hypernatremia was... read more
Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock
Favorable changes in physiologic and biochemical variables and norepinephrine dependency were observed after IHD in patients with septic shock complicated by metabolic acidosis during resuscitation. Further studies are needed... read more
Evaluation of Perioperative Medication Errors and Adverse Drug Events
One in 20 perioperative medication administrations included a medication error (ME) and/or adverse drug event (ADE). More than one third of the MEs led to observed ADEs, and the remaining two thirds had the potential for... read more
Diagnostic Accuracy of Point-of-Care Lung Ultrasonography and Chest Radiography in Adults With Symptoms Suggestive of ADHF
Standard tools used to diagnose pulmonary edema in acute decompensated heart failure (ADHF), including chest radiography (CXR), lack adequate sensitivity, which may delay appropriate diagnosis and treatment. Point-of-care... read more
The Association Between Ventilator Dyssynchrony, Delivered Tidal Volume, and Sedation Using a Novel Automated Ventilator Dyssynchrony Detection Algorithm
We developed a computerized algorithm that accurately detects three types of ventilator dyssynchrony. Double-triggered and flow-limited breaths are associated with the frequent delivery of tidal volumes of greater than... read more
Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients
The effect of short-term caloric restriction on gene expression in critically ill patients has not been studied. In this sub-study of the PermiT trial, we examined gene expression patterns in peripheral white blood cells... read more
