Tag: study
Hemodynamic Stabilization Using CRRT and cIVNa Combination Therapy
Compared with conventional continuous renal replacement therapy (CRRT), combination therapy of CRRT and continuous intravenous sodium infusion therapy (cIVNa) increased blood pressure, enhanced urinary volume, and reduced... read more
A Novel Mechanism for COVID-19 Related Thrombotic Events: Platelet NO/ROS Equilibrium
The finding that platelet NO/ROS production imbalance contributes to the elevated risk of thrombotic events in COVID-19 has important clinical implications. Restoration of platelet NO production, as well as attenuation... read more
Inadequate Empirical Antibiotic Therapy in VAP: Risk Factors and Outcomes
Ventilator-associated pneumonia (VAP) caused by MDR pathogens were highly likely to receive inadequate empirical antibiotic therapy. The mortality rate and intubation duration were significantly longer in inadequately treated... read more
Early Acetaminophen Administration Associated with Lower Mortality Among ARDS Patients After Coronary Artery Bypass Grafting
The use of acetaminophen (APAP) at 48h after coronary artery bypass grafting (CABG)-acute respiratory distress syndrome (CABG-ARDS) was associated with lower early postoperative mortality, while shortening the length of hospital... read more
Thirst Management in Orotracheally Intubated and Mechanically Ventilated Patients
Symptom Management Theory (SMT)-based thirst management is an effective strategy. The 5 mL cold water spray method significantly reduces thirst intensity and distress in mechanically ventilated patients under fasting and... read more
Serum MANF vs. Severity and Prognosis in Community-acquired Pneumonia Patients
This evidence demonstrated that serum mesencephalic astrocyte-derived neurotrophic factor (MANF) is positively associated with scoring criteria and poor prognosis in community-acquired pneumonia (CAP) patients. Serum... read more
Tocilizumab vs. IVIG in Patients with Severe COVID-19 Pneumonia
Severe COVID-19 patients who received IVIG in the early phase of the disease did not show better clinical outcomes in terms of mortality, hospitalization time and intensive care unit admission compared to those who received... read more
Levosimendan Role in ECMO for Refractory Cardiac Arrest
Levosimendan use in extracorporeal cardiopulmonary resuscitation (ECPR) did not improve survival. Neurological outcome could be representative of the short- and long-term outcomes. Future well-designed randomized trials... read more
Fever Management with or without a Temperature Control Device After OHCA and Resuscitation
the TEMP‐CARE trial will advance our understanding of post‐cardiac arrest care fever management strategies. With a large sample size and a broad patient population, the results of this trial will inform clinical practice... read more
Femoral Head Osteonecrosis in Post-COVID-19 Patients
This study provides an insight into the relationship between COVID-19-related factors and the development of osteonecrosis of the femoral head (ONFH), emphasizing the critical role of cumulative steroid dose as the primary... read more
Anesthesia Role in Sedation and Weaning From Mechanical Ventilation
This systematic review highlights the advantages of anesthetic sedation strategies, particularly the use of dexmedetomidine, methadone, or sequential sedation protocols, in improving weaning outcomes, enhancing sedation quality,... read more
Lung-protective Ventilation Strategies for Mechanical Ventilation
This study is an important step toward optimizing mechanical ventilation strategies, addressing the interplay between mechanical power, gas exchange and long-term respiratory outcomes could further refine lung-protective... read more
Severe Adenoviral Infections: Disease Progression and Poor Prognostic Markers
Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions. The... read more
Glycemic Control Role in Inflammation Markers and Clinical Outcomes in Type 2 Diabetes Patients with Severe COVID-19
This study demonstrates that among hospitalized COVID-19 patients with type 2 diabetes mellitus, poor glycemic control (HbA1c ≥ 7%) correlates with increased systemic inflammation, greater disease severity, and worse clinical... read more
Management of ARDS COVID-19 Patients Using Hemoperfusion and CRRT
Combined hemoperfusion (HP) and continuous renal replacement therapy (CRRT) hold promise as a potential intervention for severe COVID-19 cases with multiple organ dysfunction, leading to improved clinical outcomes. Fifty-six... read more
Septic Shock Metabolic Subgroups and Clinical Outcome
Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more
VA-ECMO and Pulmonary Reperfusion
The study by Stadlbauer and colleagues provides further evidence that veno-arterial extracorporeal membrane oxygenation (VA-ECMO) should—whenever necessary—be used, as a bridge to pulmonary reperfusion, but not as a bridge... read more
Rapid Clinical Effects of Convalescent Plasma Therapy in Severe COVID-19 ARDS
Administration of convalescent plasma (CP) in critically ill COVID-19 patients leads to a rapid and highly significant improvement of sequential organ failure assessment (SOFA) score along with improvements in respiratory... read more
Continuous Glucose Monitoring-Based Insulin Titration Protocol for Type 2 Diabetes Patients
The continuous glucose monitoring (CGM)-based insulin titration protocol by Olsen et al has been successfully implemented for titrating basal, prandial, and correctional insulin in inpatients with type 2 diabetes in non-ICU... read more
Fluid Management Impact on Outcomes in Sequential Extracorporeal Support
Sepsis is a life-threatening condition characterized by dysregulated inflammatory responses, often leading to multiple organ dysfunction and high mortality rates. Continuous renal replacement therapy (CRRT) and extracorporeal... read more
Leptin and Linterlukin-6 Relationship and Influence of Mortality in Sepsis
High leptin levels might counteract the adverse prognostic effect of elevated IL-6 on septic mortality. At the same IL-6 level, leptin could predict septic mortality. Leptin might be a protecting factor for men and gender-different... read more
TyG Index And Short-term Mortality in Patients with Cardiogenic Shock
The triglyceride-glucose (TyG) index is significantly associated with short-term mortality in patients with cardiogenic shock (CS) and may serve as a useful biomarker for risk stratification. This retrospective cohort... read more
