Shock Trauma to Study Body Cooling for Patients in Cardiac Arrest from Massive Bleeding

The R Adams Cowley Shock Trauma Center at the University of Maryland has opened a clinical trial to study whether rapidly cooling the body temperature of patients whose hearts stop due to massive blood loss will give surgeons... read more

Frequency of pulmonary embolism amongst patients admitted for first-time syncope

All patients admitted to an inpatient service for first-time syncope from the emergency departments of 11 Italian hospitals from 2012-2014 were evaluated for pulmonary embolism. Pulmonary embolism was found in 17.3% of patients... read more

Higher levels of tau protein found in children with early onset psychosis

New research shows that levels of a certain type of the Alzheimer's disease-related tau protein are higher in patients aged 18 years and under suffering early onset psychosis (EOP).... read more

An Expert Consensus Statement on Physical Rehabilitation After Hospital Discharge

A consensus-based framework for optimal physical therapy (PT) after hospital discharge is proposed. Future research should focus on feasibility testing of this framework, developing risk stratification tools and validating... read more

PAH Associated With Systemic Lupus Erythematosus

Patients with SLE-PAH have an overall 5-year survival rate of 83.9% after the Pulmonary Arterial Hypertension (PAH) diagnosis. Anti-SSA/SSB antibodies may be a risk factor for PAH, and the presence of anti-U1-RNP antibodies... read more

A Measure of Physicians’ Motivation to Adopt Medical Devices

This is the first reliable and valid scale to measure physicians' adoption motivation. Future adoption studies assessing the individual level should include the PMA scale to obtain more information about the role of physicians’... read more

Assessing Usefulness of Randomized Clinical Trials

In the pyramid of evidence based medicine randomized controlled trials (RCTs) are considered to be one of the most reliable study designs when evaluating the cause and effect of treatment modalities. When evaluating randomized... read more

Furosemide in the Treatment of Acute Pulmonary Edema

CHF is a common problem in the US with over 5 million patients carrying the diagnosis and 500,000 new diagnoses each year.1 Cardiogenic acute pulmonary edema (APE) occurs when blood backs up into the pulmonary vasculature... read more

Core Outcome Measures for Clinical Research in ARF Survivors

This Core Outcome Measurement Set is recommended for use in all clinical research evaluating acute respiratory failure (ARF) survivors after hospital discharge. In the future, researchers should evaluate measures for outcomes... read more

New-Onset Atrial Fibrillation in the Critically Ill

Kyle Enfield, MD, speaks with Travis J. Moss, MD, MSc, and J. Randall Moorman, MD, about the article, "New-Onset Atrial Fibrillation in the Critically Ill," published in the May 2017 issue of Critical Care Medicine. Drs.... read more

Higher PEEP versus Lower PEEP Strategies for Patients with ARDS

Use of higher positive end-expiratory pressure (PEEP) is unlikely to improve clinical outcomes among unselected patients with ARDS. We identified eight randomized trials comparing higher versus lower PEEP strategies, enrolling... read more

Is this critically ill patient elderly or too old?

Life expectancy is increasing in industrialized countries. It is forecast that in the European Union 24.4 million people will be older than 85 years in 2040, more than doubling from the 10.4 million seen in 2010. In parallel,... read more

Understanding Adrenal Crisis

Approximately 5–17 cases of adrenal crisis (AC) occur per 100 patient years in patients with primary or secondary adrenal insufficiency (AI). The mortality rate is estimated to be between 0.5% and 2%. Norwegian data indicate... read more

Alarm Fatigue in ICU Addressed in Two Studies

Alarm fatigue within the intensive care unit (ICU) can negatively impact patient safety and lead to life-threatening events. Researchers from Harlem Hospital and Maimonides Medical Center aimed to identify solutions fight... read more

Bedside Chest Radiographs in the ICU – DRw vs. CR

Critical care chest radiography with a portable wireless direct radiography (DRw) system can provide similar or superior information compared to a computed radiography (CR) system regarding clinically significant findings... read more

Translational Evidence for Two Distinct Patterns of Neuroaxonal Injury in Sepsis

Ischemic and diffuse neuroaxonal injury to the brain in experimental sepsis, human postmortem brains, and in vivo MRI suggest these two distinct lesion types to be relevant. Future studies should be focused on body fluid... read more

Barriers to Delirium Assessment in the ICU

Many barriers exist to prevent effective assessment and management of delirium, but several of these are due to a lack of understanding or unfamiliarity with the condition and the assessment tools as well as lack of medical... read more

Oral Antibiotics Preferred for Pediatric Pneumonia

Children with complicated pneumonia should be discharged from the hospital with oral instead of intravenous (IV) antibiotics when possible, according to a new study. The results showed no significant differences in treatment... read more

Aerosol Delivery During Invasive Mechanical Ventilation

Lung deposition was lower than 20% of nominal dose delivered with nebulizers and mostly occurred in proximal airways. Further studies are needed to link substantial concentrations of antibiotics in infected pulmonary fluids... read more

Can this patient be safely weaned from RRT?

The timing of initiation of renal replacement therapy (RRT) in the critically ill with acute kidney injury (AKI) has been widely studied and discussed in detail recently. However, there is limited information and few recommendations... read more

Active Noise Control Headphones to Reduce Patient’s Exposure to ICU Noise

The use of active noise cancellation, as delivered by noise-cancelling headphones, is associated with a significant reduction in noise exposure in our model of noise exposure in a cardiac ICU. This is the first study to look... read more

Opioid use to worse outcomes in C. difficile

A study presented at the World Congress of Gastroenterology found that patients being prescribed opioids who also have Clostridium difficile infections (CDIs) have higher peak white blood cell counts, higher creatinine elevations,... read more