Tag: therapy
Safety and Efficacy of MUST-ARDS
This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more
Use of Hemoadsorption in Patients With Severe Intoxication Requiring ECMO
Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the... read more
Adrenal Insufficiency in Patients Taking Benralizumab as Corticosteroid Sparing Therapy
A personalised regimen of tapering oral corticosteroids in the presence of the anti-IL5 receptor α-directed cytolytic monoclonal antibody benralizumab can help to achieve elimination or dose reduction of oral corticosteroids... read more
Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis
We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more
Acute Eosinophilic Pneumonia Secondary to Daptomycin
Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more
Essentials of Aerosol Therapy in Critically Ill Patients
This book assesses the most appropriate forms of aerosol therapy for critically ill patients. Aerosol therapy is applied for the treatment of several pulmonary diseases in addition to some promising applications intended... read more
Fluvoxamine COVID-19 Treatment: Positive Impact on Patient Survival
Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID-19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID-19 patients are urgently... read more
Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest
Low levels of brain injury markers in blood are associated with good neurological outcome after CA. Incorporating biomarkers into neuroprognostication may help prevent premature withdrawal of life-sustaining therapy. Retrospective... read more
Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS
Acute respiratory distress syndrome (ARDS) is a clinically heterogenous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients... read more
Impact of ABCDE Bundle Implementation in the ICU on Specific Patient Costs
Full ABCDE bundle implementation resulted in a decrease in total hospital laboratory costs and total hospital laboratory and diagnostic resource utilization while leading to an increase in physical therapy costs. The full... read more
COVID-19 Variants in Patients with Immunosuppression
Patients with immunosuppression are at risk for prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In several case reports, investigators have indicated that multimutational SARS-CoV-2... read more
Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension
In patients having intermediate- to high-risk surgery, computer-assisted individualized hemodynamic management significantly reduces intraoperative hypotension compared to a manually controlled goal-directed approach. All... read more
Milrinone vs. Dobutamine in the Treatment of Cardiogenic Shock
In patients with cardiogenic shock, no significant difference between Milrinone and Dobutamine was found with respect to the primary composite outcome or important secondary outcomes. A total of 192 participants (96 in... read more
Eosinophilic Esophagitis
Once considered a rare condition, eosinophilic esophagitis is now one of the most common conditions diagnosed during the assessment of feeding problems in children and during the evaluation of dysphagia and food impaction... read more
Delirium and long term cognition in critically ill patients
Delirium, a form of acute brain dysfunction, is very common in the critically ill adult patient population. Although its pathophysiology is poorly understood, multiple factors associated with delirium have been identified,... read more
Steer Clear of Magnesium for COPD
Knowingly or not, we in emergency medicine tend to lean into the Dutch hypothesis, a 1960s postulate that asthma and COPD are part of a spectrum of common disease (chronic obstructive lung disease), and should be considered... read more
Decreased Mortality in ARDS Patients Treated with Corticosteroids
The use of glucocorticoids might result in reduced mortality in patients with ARDS. Glucocorticoids might be recommended as an adjunct to standard care for ARDS; however, the optimal dose and duration of steroid therapy remains... read more
