Tag: trial
COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis
Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more
Ground-breaking Research – Venous Thrombosis is Back in Business
The primary efficacy outcome was the development of a major venous thromboembolic event such as symptomatic distal or proximal deep-vein thrombosis, asymptomatic deep vein thrombosis, pulmonary embolism or venous thromboembolism–related... read more
Cost Analysis of Adjunctive Hydrocortisone Therapy for Septic Shock
Using adjunctive hydrocortisone therapy yields a significant monetized benefit based on inputs from the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock and Activated Protein C and Corticosteroids... read more
SARS-CoV-2-reactive T Cells in Healthy Donors and Patients with COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to... read more
High Breath-by-Breath Variability Is Associated With Extubation Failure in Children
High respiratory variability during spontaneous breathing trials is independently associated with extubation failure in children, with very high rates of extubation failure when these children develop postextubation upper... read more
Dexmedetomidine for Prolonged Sedation in the PICU
High-quality data on dexmedetomidine use for prolonged sedation and a consensus on correct dosing and weaning protocols in children are currently missing. Infusion of dexmedetomidine can be considered relatively safe in pediatrics... read more
Moderna mRNA Vaccine Candidate’s Phase I Trial
Eight weeks to the day after press-releasing some top line results, the full paper is out on the Moderna mRNA vaccine candidate’s Phase I trial. I'm very glad to see it – it's going to be very important for the full data... read more
Heparin 2.0: A New Approach to the Infection Crisis
In April 2020, the US Food and Drug Administration granted emergency use authorization for certain medical devices to be used in patients with coronavirus disease 2019 (COVID-19). This included extracorporeal blood purification... read more
COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies
Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... read more
COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box
Study shows that aerosol box used to protect healthcare workers during COVID intubation increases, rather than decreases, exposure to airborne particles. A new study shows that aerosol boxes that have been manufactured... read more
Incidence of Pulmonary Embolism in Non-critically ill COVID-19 Patients
Recent studies suggest that thrombotic complications are a common phenomenon in the novel SARS-CoV-2 infection. The main objective of our study is to assess cumulative incidence of pulmonary embolism (PE) in non critically... read more
Harm of IV High-Dose Vitamin C Therapy in Adult Patients
There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials. However, reports of oxalate nephropathy, hypernatremia, glucometer error, and... read more
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19
Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... read more
Effect of Dexamethasone in Hospitalized Patients with COVID-19
Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... read more
Biomarkers of Sepsis: Time for a Reappraisal
The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more
Prevention, Detection and Management of VTE in COVID-19 Patients
Several studies have demonstrated coagulation changes in patients with COVID-19, especially in those with severe disease, and this is associated with a worse prognosis. Emerging data, alongside recent clinical experience,... read more
Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam
This case demonstrates the importance of rapid recognition and treatment of hydroxychloroquine poisoning. We anticipate that clinicians may be asked to recognize and manage this toxidrome in increasing frequency as attention... read more
An Evidence-Based Approach to Pressors in Shock
The evaluation and treatment of patients with cardiovascular shock is a cornerstone of emergency care. Unfortunately, the literature behind the use of vasoactive medications in cardiovascular shock is inconsistent. A Cochrane... read more
