Tag: trial
Frailty and Subsequent Disability and Mortality among Patients with Critical Illness
The prevalence of frailty (diminished physiologic reserve) and its effect on outcomes for those aged 18 years and older with critical illness is unclear. Frailty is common in critically ill adults aged 18 years and older... read more
FDA approves betrixaban for VTE prophylaxis
Betrixaban, a factor Xa inhibitor, has been approved for the prophylaxis of venous thromboembolism (VTE) in at-risk adult patients hospitalized with an acute illness, according to an announcement from the Food and Drug Administration.... read more
A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses
Uncomplicated skin abscesses are common, yet the appropriate management of the condition in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear. As compared with incision and drainage... read more
Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients
A decreased frequency of upper gastrointestinal bleeding and a possible association of proton pump inhibitor use with Clostridium difficile and ventilator-associated pneumonia have raised concerns recently. The Reevaluating... read more
Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke
The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice. Disability outcomes after... read more
Prevention of AKI and protection of renal function in ICU
Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. The results of recent randomised controlled trials have allowed the formulation of new recommendations and/or increase... read more
A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients
Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existingclinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein receivedearly in the... read more
A Randomized Trial of the Amikacin Fosfomycin Inhalation System for the Adjunctive Therapy of Gram-Negative VAP
Clinical failures in ventilator-associated pneumonia (VAP) caused by gram-negative bacteria are common and associated with substantial morbidity, mortality, and resource utilization. In this trial of adjunctive aerosol therapy... read more
Management of Septic Shock
The results of the PRISM trials confirm that early intervention strategies, including early detection of sepsis, risk stratification, early administration of antibiotics, and appropriate fluid resuscitation, improve the outcomes... read more
Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients
Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective non-cardiac surgery. Postoperative delirium occurs in 10% to 60%... read more
Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation
In this randomized clinical trial of 116 patients, the addition of home noninvasive ventilation significantly prolonged time to readmission or death from 1.4 months to 4.3 months. Among patients with persistent hypercapnia... read more
Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality
Clinical trials have documented that lowering blood pressure reduces cardiovascular disease and premature deaths. However, the optimal target for reduction of systolic blood pressure (SBP) is uncertain. This study suggests... read more
Data Sharing Statements for Clinical Trials
The International Committee of Medical Journal Editors (ICMJE) believes there is an ethical obligation to responsibly share data generated by interventional clinical trials because trial participants have put themselves at... read more
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study
Sevoflurane improves gas exchange, and reduces alveolar edema and inflammation in preclinical studies of lung injury, but its therapeutic effects have never been investigated in acute respiratory distress syndrome (ARDS).... read more
Accuracy of Medical Claims for Identifying Cardiovascular and Bleeding Events After Myocardial Infarction
In this secondary analysis of a clinical trial of 12 365 patients with acute myocardial infarction, the cumulative 1-year event rates for myocardial infarction, stroke, and bleeding were lower when medical claims were used... read more
Personalised Medicine in Intensive Care
The specialty of intensive care medicine grew out of the realisation that critically ill patients needed more attention and specialised treatment than could be provided on a general ward, and that many of these patients had... read more
Using Ventilator to Control Oxygen May Be COPD Game-changer
Using a ventilator to control the level of supplemental oxygen a chronic obstructive pulmonary disease (COPD) patient receives halved patients' trips to the hospital from disease flare-ups, according to a clinical trial. British... read more
Effect of Home NIV on Outcomes After Acute COPD Exacerbation
This randomized clinical trial compares the effects of home oxygen therapy with vs without home noninvasive ventilation (NIV) on time to readmission or death in patients with persistent hypercapnia after an acute chronic... read more
Ramped Position versus Sniffing Position during Endotracheal Intubation
A Multicenter, Randomized Trial of Ramped Position versus Sniffing Position during Endotracheal Intubation of Critically Ill Adults. Hypoxemia is the most common complication during endotracheal intubation of critically ill... read more
Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock
The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine... read more
The vaccine study you will never see
I’ve seen a lot of social media posts or comment threads that say we don’t have any studies to prove that the CDC's vaccine schedule is safe or effective. I think they mean that we haven’t done the best study. As... read more
