Tag: trial
Six myths promoted by the new surviving sepsis guidelines
The Rivers trial and the Surviving Sepsis Campaign popularized sepsis protocols, which saved lives. Massive accomplishment. However, that doesn’t validate the individual components of early goal-directed therapy. Any protocol... read more
Benefits and harms of duloxetine for treatment of stress urinary incontinence
Duloxetine was significantly better than placebo in terms of percentage change in weekly incontinence episodes (mean difference - 13.56%, 95% confidence interval [CI] -21.59% to -5.53%) and change in Incontinence Quality... read more
The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families
Over the past 20 years, critical care has matured in a myriad of ways resulting in dramatically higher survival rates for our sickest patients. For millions of new survivors comes de novo suffering and disability called "the... read more
Effects of Video vs Direct Laryngoscopy on Successful Orotracheal Intubation in ICU Patients
Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more
Magnet guidance reduces misplacement of subclavian vein catheter in internal jugular vein
The internal jugular vein (IJV) and subclavian vein (SCV) are the two most commonly used insertion sites for central venous catheterization (CVC). A multicenter clinical trial compared commonly used insertion sites and... read more
Better glycemic control with continuous glucose monitoring
This randomized clinical trial compares the effects of continuous glucose monitoring vs conventional treatment for glycemic control in adult patients with type 1 diabetes treated with multiple daily insulin injections.... read more
Liberation from Mechanical Ventilation in Critically Ill Adults
Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. The panel provides recommendations... read more
Effect of Omega 3 polyunsaturated fatty acids in major burn patients
The inclusion of ω-3 PUFAs in a low fat diet in ICU burned patients was associated with significant clinical benefits compared to a conventional low fat diet, with lower rates of severe sepsis, septic shock and pyloric dysfunction.... read more
Towards precision medicine for sepsis patients
Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as hyperinflammation-induced organ failure. In contrast to the previous belief... read more
No difference between placebo, amitriptyline and topiramate in reducing pediatric migraine
In this study, no significant intergroup differences between amitriptyline, topiramate and placebo for reduction in total number of headache days was observed. Amitriptyline and topiramate were associated with significantly... read more
Spinraza Cuts Risk of Permanent Ventilation with SMA
Biogen announced new data from the Phase 3 ENDEAR study that showed a statistically significant reduction in the risk of death or permanent ventilation in Spinraza (nusinersen)-treated infants with spinal muscular atrophy... read more
Statins for Primary Prevention
A recent issue of JAMA contains the latest US Preventive Services Task Force (USPSTF) recommendation statement on statins for prevention of cardiovascular disease in adults, along with the accompanying evidence report and... read more
Beta-Blockers Linked to Reduced Mortality in HFrEF
Beta-blockers are associated with significantly reduced mortality, but not hospitalizations, in patients with heart failure and reduced ejection fraction (HFrEF) and atrial fibrillation (AF). The researchers found that β-blockers... read more
First deep brain stimulation surgery on stroke patient
Cleveland Clinic performed the nation's first deep brain stimulation surgery on a stroke patient. This is part of an ongoing clinical trial that’s evaluating whether DBS can improve movement after a stroke. Only 10... read more
Induced hypothermia not associated with better outcomes for status epilepticus
In this trial, induced hypothermia added to standard care was not associated with significantly better 90-day outcomes than standard care alone in patients with convulsive status epilepticus.... read more
Serum biomarker associated with metformin dosing or use
The growth differentiation factor 15 (GDF15) is a novel biomarker for the use and dosing of metformin, according to a study published online Dec. 14 in Diabetes Care. 237 serum biomarkers from participants in the Outcome... read more
Effectiveness of Pre-Hospital Blood Products
University of Warwick is collaborating with researchers at the NIHR Surgical Reconstruction and Microbiology Research Centre (SRMRC) to support a ground-breaking new study to investigate the effectiveness of giving patients... read more
Plazomicin Succeeds in Phase 3 cUTI and CRE Trial
Plazomicin an antibiotic being developed to fight multidrug-resistant bacterial infections, has met the primary objective of noninferiority compared with meropenem in a phase 3 registration trial among patients with complicated... read more
Glutamine, fish oil and antioxidants in critical illness
We hypothesize that the harmful effect of IMHP compared to HP enteral nutrition in a heterogeneous group of critically ill patients is limited to the medical critically ill patients and mediated by an early increase in (epa... read more
Randomised trials role in surgery
In medical science, as in all walks of life, we are impressed by dramatic effects. If a new treatment seems much better than an old one initially, there is often impatience to get on and use it, and people question why... read more
Improving Appropriate Neurologic Prognostication after Cardiac Arrest
A multicenter quality intervention improved rates of appropriate neurologic prognostication after OHCA but did not increase survival with good neurologic outcome. This was a pragmatic stepped wedge cluster randomized controlled... read more
Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest
Acute administration of exenatide to comatose patients in the ICU after OHCA is feasible and safe. Exenatide did not reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and... read more
