Tag: trial
Dexmedetomidine Use in Critically-Ill Children with Acute Respiratory Failure
Margaret Parker, MD, MCCM, speaks with Mary Jo C. Grant, APRN, PhD, about the article, "Dexmedetomidine Use in Critically-Ill Children with Acute Respiratory Failure," published in the December 2016 issue of Pediatric... read more
Short-term Effects of High-Dose Caffeine on Cardiac Arrhythmias in Patients With Heart Failure
This randomized clinical trial evaluates the short-term effects of high-dose caffeine consumption vs placebo in patients with heart failure at increased risk for arrhythmic events. After 500 mg of caffeine administered over... read more
Pulmaquin Looks Promising for Treating Lung Infections in Non-CF Bronchiectasis Patients
Aradigm has announced top-line results from two Phase 3 clinical trials of Pulmaquin (inhaled ciprofloxacin) for the treatment of patients with non-cystic fibrosis bronchiectasis (non-CF BE) who have chronic lung infections... read more
Benefits of PCI for STEMI Not Attenuated in Patients With a Cancer History
Having a history of cancer does not worsen outcomes for patients with STEMI who undergo primary PCI and should not be a barrier to revascularization and optimal therapy.... read more
Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit
A novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference... read more
Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation
Ten trials met the inclusion criteria for this review (n = 1658 participants). We found five trials to be at low risk of bias and five to be at moderate risk of bias.... read more
Vasopressin vs. norepinephrine for vasoplegic shock after cardiac surgery
Patients in the VANISH trial treated with vasopressin had a lower incidence of renal failure requiring hemodialysis. However, this was a secondary endpoint which seemed to contradict the primary endpoint (defined as a milder... read more
PCSK9 Inhibition and Other New Therapies for Lipid Modification: Good News and Bad
A late-breaking clinical trial session devoted to newly approved and investigational compounds for the treatment of lipids highlighted the end of a once promising therapy for low HDL cholesterol.... read more
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS.... read more
Long-Term Oxygen for COPD with Moderate Desaturation
The prescription of long-term supplemental oxygen did not result in a longer time to death or first hospitalization than no long-term supplemental oxygen in patients with stable COPD.... read more
Glyburide Promising for Treatment of Acute Ischemic Stroke
Although the study did not demonstrate efficacy of glyburide, differences were seen in the amount midline shift at 3-4 days. In the current study, 86 patients with large (82-300 cc) anterior circulation stroke were randomized... read more
Old vs New: End of Debate on Blood Transfusion Storage
The new data come from the Informing Fresh versus Old Red Cell Management (INFORM) trial, which assigned hospitalized patients to receive transfusion of the freshest red cells in the inventory.... read more
Baxter initiates late-stage study of novel therapy for acute kidney injury
Baxter International commences a Phase 3 clinical trial assessing an investigational drug, Prismocitrate 18, that combines a citrate anticoagulant and renal replacement solution.... read more
Abdominal Aortic Aneurysm Screening
The long-term follow-up of the Western Australian trial of screening for abdominal aortic aneurysms (AAAs) reported in this issue of JAMA Internal Medicine1 is likely the last report from the 4 randomized clinical trials1- 4... read more
Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients
Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would... read more
Hospitals embed mental health professionals in the ICU
Pilot programs at several large academic medical centers suggest that integrating psychiatrists and other mental-health professionals into hospital units.... read more
Acute caffeine ingestion does not increase arrhythmias in patients with chronic systolic heart failure
Acute ingestion of caffeine did not increase the risk of ventricular or supraventricular arrhythmias as compared to placebo in patients with chronic systolic heart failure, either at rest or during a symptom-limited exercise... read more
Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome
In sepsis-associated ARDS, hydrocortisone treatment was associated with a significant improvement in pulmonary physiology, but without a significant survival benefit.... read more
Blood products and procoagulants in traumatic bleeding
A host of preclinical and clinical studies have evaluated blood product availability and efficacy in trauma. Recently published randomized controlled trials have investigated the ratio of platelet:plasma:red cell transfusion... read more
Palliative-care boosts heart failure patient outcomes
Adding palliative care interventions to management of patients with advanced heart failure improved quality-of-life measures in two relatively small, controlled studies.... read more
More NOAC Comparisons See More Bleeding With Rivaroxaban: Is the ‘Writing on the Wall’?
Evidence is mounting, albeit from observational studies, that while all of the non-vitamin K antagonist oral anticoagulants (NOACs) appear to have similar efficacy in terms of stroke reduction in atrial fibrillation, they... read more
