Predicting Readmission or Death After Discharge From the ICU with Machine Learning

Predicting Readmission or Death After Discharge From the ICU with Machine Learning

In this era of expanding availability of ML models, external validation and retraining are key steps to consider before applying machine learning (ML) models to new settings. Clinicians and decision-makers should take... read more

Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients

Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients

Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more

Improving Outcomes in Patients with Difficult Airways

Improving Outcomes in Patients with Difficult Airways

Evidence indicates that the airway community has successfully conquered the anatomically difficult airway, as these patients are managed safely with a low incidence of morbidity and mortality. In contrast, the literature... read more

High Dose Insulin and Euglycemia Therapy for Beta-adrenergic Receptor Treatment and Calcium Channel Antagonists Overdose

High Dose Insulin and Euglycemia Therapy for Beta-adrenergic Receptor Treatment and Calcium Channel Antagonists Overdose

High dose insulin with dextrose supplementation is indicated for patients with calcium channel blocker and beta blocker overdose and signs of cardiac toxicity. Mechanisms are not completely elucidated, but mostly related... read more

Vasopressor Choice and Timing in Vasodilatory Shock

Vasopressor Choice and Timing in Vasodilatory Shock

Vasodilatory shock is the most common form of circulatory shock encountered in patients admitted to the intensive care unit (ICU). Sepsis is the predominant etiology, but other causes of vasodilatory shock include postoperative... read more

Reducing Mortality in Acute Kidney Injury

Reducing Mortality in Acute Kidney Injury

This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney... read more

Septic Shock and Vasopressor Initiation: Why Earlier is Better

Septic Shock and Vasopressor Initiation: Why Earlier is Better

An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock... read more

Arterial pH with Hemodynamic Response Association to Vasopressin in Patients with Septic Shock

Arterial pH with Hemodynamic Response Association to Vasopressin in Patients with Septic Shock

Compared with higher arterial pH, patients with septic shock and low arterial pH had lower odds of vasopressin response and higher catecholamine doses after vasopressin initiation. Similar to other vasopressors, the clinical... read more

Intravenous Vitamin C Administration to Septic Shock Patients

Intravenous Vitamin C Administration to Septic Shock Patients

Our pilot study indicated that intravenous vitamin C did not provide significant decreases in the mean dose or duration of vasopressor infusion. Further research that takes into account the potential impact of intervention... read more

Equipotent Ratios for the Most Common Vasopressors

Equipotent Ratios for the Most Common Vasopressors

Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more

Evaluating Vitamin C in Septic Shock

Evaluating Vitamin C in Septic Shock

Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized. Our findings do not support its routine clinical use for this purpose. Of 124 subjects receiving study drug and included... read more

Vasopressor Initiation within 1 Hour of Fluid Loading is Associated with Increased Mortality in Septic Shock Patients

Vasopressor Initiation within 1 Hour of Fluid Loading is Associated with Increased Mortality in Septic Shock Patients

Vasopressor initiation within 1 hour of fluid loading was associated with higher 28-day mortality in patients with septic shock. The median time from the initial fluid bolus to vasopressor was shorter in the early group... read more

Predict Sepsis-Associated Vasopressor Use in the ICU

Predict Sepsis-Associated Vasopressor Use in the ICU

Domain adaptation improved performance of a model predicting sepsis-associated vasopressor use during external validation. 40 retrospectively collected features from the electronic medical records of adult ICU patients... read more