Tag: vasopressors
Intravenous Vitamin C Administration to Septic Shock Patients
Our pilot study indicated that intravenous vitamin C did not provide significant decreases in the mean dose or duration of vasopressor infusion. Further research that takes into account the potential impact of intervention... read more
Equipotent Ratios for the Most Common Vasopressors
Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more
Evaluating Vitamin C in Septic Shock
Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized. Our findings do not support its routine clinical use for this purpose. Of 124 subjects receiving study drug and included... read more
Vasopressor Initiation within 1 Hour of Fluid Loading is Associated with Increased Mortality in Septic Shock Patients
Vasopressor initiation within 1 hour of fluid loading was associated with higher 28-day mortality in patients with septic shock. The median time from the initial fluid bolus to vasopressor was shorter in the early group... read more
Predict Sepsis-Associated Vasopressor Use in the ICU
Domain adaptation improved performance of a model predicting sepsis-associated vasopressor use during external validation. 40 retrospectively collected features from the electronic medical records of adult ICU patients... read more
COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?
In CRITICALLY ILL patients with COVID-19, an initial strategy of therapeutic-dose anticoagulation is not associated with a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular... read more
Epidemiology of Intravenous Immune Globulin in Septic Shock
Intravenous immune globulin is used infrequently across the US in patients with septic shock. Regimens of IVIG in septic shock may be less intensive than those associated with a survival benefit in meta-analyses. Observed... read more
Balanced Solution vs. 0.9% Saline Solution Fluid Treatment in Critically Ill Patients
Among critically ill patients requiring fluid challenges, use of a balanced solution compared with 0.9% saline solution did not significantly reduce 90-day mortality. The findings do not support the use of this balanced... read more
Patients Discharged From the ICU on a Dopamine Infusion
Despite a higher ICU readmission rate, ICU discharge of patients on dopamine infusion was not associated with increased mortality. The hospital mortality rate was comparable in both groups, despite that the median logistic... read more
RRT in Critically Ill Patients with AKI
Recent evidence has shown that pre-emptive or earlier renal-replacement therapy (RRT) in patients with severe acute kidney injury (AKI) and no urgent indications does not confer clinical benefit. By default, this would imply... read more
Protocol and statistical analysis plan for the PREPARE II randomised clinical trial
Cardiovascular collapse is a common complication during tracheal intubation of critically ill adults. Whether administration of an intravenous fluid bolus prevents cardiovascular collapse during tracheal intubation remains... read more
Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities
Vasopressors are commonly used in the treatment of shock to support blood pressure, cardiac output, and end-organ perfusion. These agents are associated with risk of serious adverse effects including ischemia (e.g. stroke,... read more
Oral Midodrine Feasibility in Early Sepsis
This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more
Cytokine Adsorption Effect on Survival and Circulatory Stabilization in Patients Receiving ECPR
Even after the introduction of extracorporeal cardiopulmonary resuscitation (ECPR), survival after cardiac arrest remains poor. Excess release of vasoactive cytokines may be a reason for cardiovascular instability and death... read more
The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients
In the second of a series of manuscripts subsequent to the original article, members with expertise in the subjects expound upon the three identified priorities related to fluid resuscitation and vasopressor therapies. This... read more
Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients
In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events—in particular cardiovascular instability—were... read more
Key Topics in Critical Care
High quality critical care medicine is a crucial component of advanced health care. Completely revised and updated, Key Topics in Critical Care, Second Edition provides a broad knowledge base in the major areas of critical... read more
Adverse Events in the ICU During Bed-Bath Procedures
Serious adverse events were observed in one-half of patients and concerned one-fifth of nurses, confirming the need for caution. Further studies are needed to test systematic serious adverse event prevention strategies. The... read more
External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients
This exploratory analysis provides further evidence that corticosteroid exposure may be associated with increased mortality among septic shock endotype A patients. We previously reported gene expression-based endotypes... read more
Outcomes of Patients Requiring Prolonged Acute vs. Short-Term Mechanical Ventilation
Over one-third of all hospitalized patients on mechanical ventilation require it for greater than or equal to 4 days. Prolonged acute mechanical ventilation patients exhibit a higher burden of both chronic and acute illness... read more
Angiotensin II in Post Cardiopulmonary Bypass Vasoplegia
Post cardiopulmonary bypass vasoplegia is common, and associated with poor outcomes. Traditional management strategies involving escalating doses of catecholamines, vasopressin and adjuncts such as methylene blue and hydroxycobalamin... read more
