Weaning from Ventilation and Extubation of Children in Critical Care

By reading this article, you should be able to: - Identify the predictors of successful extubation in pediatric ICU (PICU) patients. - Describe the factors affecting mechanical ventilator weaning in PICU patients. -... read more

Weaning from Ventilation and Extubation of Children in Critical Care

Staff Experiences Relating to Early Mobilisation of Mechanically Ventilated Patients in Intensive Care

Early mobilisation of mechanically ventilated patients has been suggested to be effective in mitigating muscle weakness, yet it is not a common practice. Understanding staff experiences is crucial to gain insights into what... read more

Staff Experiences Relating to Early Mobilisation of Mechanically Ventilated Patients in Intensive Care

Optimal Respiratory Support for COVID-19 Patients

Noninvasive respiratory support is an essential component of critical care. Both noninvasive ventilation, with its different interface types and modes (including helmet and face masks), and high-flow nasal oxygen (HFNO) are... read more

Optimal Respiratory Support for COVID-19 Patients

Ventilator Capacity Management Queuing Model During COVID-19 Pandemic

We applied a queuing model to inform ventilator capacity planning during the first wave of the COVID-19 epidemic in the province of British Columbia (BC), Canada. The core of our framework is a multi-class Erlang loss model... read more

Ventilator Capacity Management Queuing Model During COVID-19 Pandemic

Lessons Learned From the First 50 COVID-19 Critical Care Transfer Missions

Critically ill COVID-19 patients have highly complex medical needs during transport. Critical care transfer of COVID-19-positive patients by civilian HEMS services, including air transfer, can be achieved safely with specific... read more

Lessons Learned From the First 50 COVID-19 Critical Care Transfer Missions

Non-Invasive Ventilation and Weaning: Principles and Practice, Second Edition

Now in full-colour, this eagerly-anticipated second edition continues to be the most comprehensive resource available on non-invasive ventilation (NIV), both in the hospital and at home. Reflecting a global perspective with... read more

Non-Invasive Ventilation and Weaning: Principles and Practice, Second Edition

Prone Positioning Effect on Adult Patients Survival Receiving vvECMO for ARDS

This systematic review and meta-analysis of 13 studies (total N = 1836) showed that PP of acute respiratory distress syndrome (ARDS) patients receiving venovenous ECMO (vvECMO) was associated with a significant improvement... read more

Prone Positioning Effect on Adult Patients Survival Receiving vvECMO for ARDS

Energy Transmission in Mechanically Ventilated Children

Mechanical energy (ME) better related to underlying lung pathology and patient outcome than MP. The delivery of generated energy to the lung was not dependent on endotracheal tube diameter (ETT) size during PC ventilation.... read more

Energy Transmission in Mechanically Ventilated Children

Ventilator Modes Made Easy: An Easy Reference for RRT’s, RN’s, and Medical Residents

Who says understanding ventilator modes has to be hard? This book gives you easy to understand information that every RRT, RN, or Resident always wishes they had. Each mode is described in simple language and answers the... read more

Ventilator Modes Made Easy: An Easy Reference for RRT’s, RN’s, and Medical Residents

Mechanical Ventilation Promotes Lung Tumor Spread by Modulation of Cholesterol Cell Content

Mechanical stretch of cancer cells can alter their invasiveness. During mechanical ventilation, lungs may be exposed to an increased amount of stretch, but the consequences on lung tumors have not been explored. To characterize... read more

Mechanical Ventilation Promotes Lung Tumor Spread by Modulation of Cholesterol Cell Content

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were... read more

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Intubation Practice and Outcomes Among Pediatric Emergency Departments

While tracheal intubation (TI) characteristics vary between pediatric Emergency Departments and ICUs, outcomes are similar. Shock and limited mouth opening were independently associated with adverse TI events in the Emergency... read more

Intubation Practice and Outcomes Among Pediatric Emergency Departments

Endotracheal Intubation vs. Supraglottic Procedure in Pediatric OHCA

The findings of this large cohort study suggest that endotracheal intubation (ETI) in pediatric out-of-hospital cardiac arrest (OHCA), although performed by trained physicians, is associated with a worse outcome, regardless... read more

Endotracheal Intubation vs. Supraglottic Procedure in Pediatric OHCA

To Bronch or Not to Bronch – That Is the Question

Percutaneous tracheostomy was safely and effectively performed by an experienced surgical team both with and without bronchoscopic guidance with no difference in the complication rates. This study suggests that the use... read more

To Bronch or Not to Bronch – That Is the Question

High-Flow Oxygen Therapy vs. Conventional Oxygen Therapy on Invasive Mechanical Ventilation in COVID-19 Patients

Among patients with severe COVID-19, use of high-flow oxygen through a nasal cannula significantly decreased need for mechanical ventilation support and time to clinical recovery compared with conventional low-flow oxygen... read more

High-Flow Oxygen Therapy vs. Conventional Oxygen Therapy on Invasive Mechanical Ventilation in COVID-19 Patients

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

Noninvasive Ventilation and Outcomes in Bronchiolitis

In a large cohort of infants at children’s hospitals, noninvasive and invasive ventilation increased significantly from 2010 to 2018. Hospital-level noninvasive ventilation utilization was not associated with a reduction... read more

Noninvasive Ventilation and Outcomes in Bronchiolitis

Non-invasive vs. Invasive Respiratory Management Strategies in AHRF Patients

When performing non-invasive ventilation among patients with de novo acute hypoxaemic respiratory failure (AHRF), it is important to avoid excessive tidal volume and lung injury. Although pressure support is needed for... read more

Non-invasive vs. Invasive Respiratory Management Strategies in AHRF Patients

Facemask vs. Helmet – Noninvasive Ventilation

We use Noninvasive ventilation (NIV) to treat various disease processes, such as acute hypercapnic and hypoxemic respiratory failure, post-extubation failure, and neuromuscular diseases. Data supports NIV use in some conditions,... read more

Facemask vs. Helmet – Noninvasive Ventilation

Weaning Methods From Mechanical Ventilation in Adult Patients

In general consideration, our study provided evidence that weaning with proportional assist ventilation has a high probability of being the most effective ventilation mode for patients with mechanical ventilation regarding... read more

Weaning Methods From Mechanical Ventilation in Adult Patients

Head Rotation in Anaesthetised Apnoeic Patients Significantly Increases Mask Ventilation Efficiency

Head rotation of 45° in anaesthetised apnoeic adults significantly increases the efficiency of mask ventilation compared with the neutral head position. Head rotation is an effective alternative to improve mask ventilation... read more

Head Rotation in Anaesthetised Apnoeic Patients Significantly Increases Mask Ventilation Efficiency

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery

Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary... read more

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery