High Flow Nasal Cannula Benefits and Pitfalls
Emergency physicians should be familiar with the benefits and pitfalls of high-flow nasal cannula (HFNC). HFNC is well tolerated by patients, and its use contributes to superior outcomes for patients with pure hypoxemic... read more
Evaluation of Perioperative Medication Errors and Adverse Drug Events
One in 20 perioperative medication administrations included a medication error (ME) and/or adverse drug event (ADE). More than one third of the MEs led to observed ADEs, and the remaining two thirds had the potential for... read more
Tailoring Nutrition Therapy to Illness and Recovery
Without doubt, in medicine as in life, one size does not fit all. We do not administer the same drug or dose to every patient at all times, so why then would we live under the illusion that we should give the same nutrition... read more
Diagnostic Accuracy of Point-of-Care Lung Ultrasonography and Chest Radiography in Adults With Symptoms Suggestive of ADHF
Standard tools used to diagnose pulmonary edema in acute decompensated heart failure (ADHF), including chest radiography (CXR), lack adequate sensitivity, which may delay appropriate diagnosis and treatment. Point-of-care... read more
The Association Between Ventilator Dyssynchrony, Delivered Tidal Volume, and Sedation Using a Novel Automated Ventilator Dyssynchrony Detection Algorithm
We developed a computerized algorithm that accurately detects three types of ventilator dyssynchrony. Double-triggered and flow-limited breaths are associated with the frequent delivery of tidal volumes of greater than... read more
Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients
The effect of short-term caloric restriction on gene expression in critically ill patients has not been studied. In this sub-study of the PermiT trial, we examined gene expression patterns in peripheral white blood cells... read more
Bougies for all intubations led to high success rates, even on difficult airways
In a randomized trial, the routine use of bougies on every DL intubation led to a higher rate of first-pass intubation success. And even allowing for the two-step technique (bougie insertion followed by ET tube insertion),... read more
Seizure Detection Algorithms in Critically Ill Children
Some commercially available seizure detection algorithms demonstrate performance for seizure detection that is comparable to that of electroencephalography experts using quantitative electroencephalography displays. Continuous... read more
Influence of Dyskalemia at ICU Admission and Early Dyskalemia Correction on Survival
Dyskalemia is common at ICU admission and associated with increased mortality. Occurrence of cardiac events increased with dyskalemia depth. A correction of serum potassium level by day 2 was associated with improved... read more
Quantitative EEG for Detection of Brain Ischemia
Electroencephalography (EEG) is a very promising tool for monitoring brain function in real-time in the ICU. There are characteristic changes that occur on EEG in response to brain ischemia, correlating with CBF and brain... read more
Machine Learning for Patient Risk Stratification for ARDS
An acute respiratory distress syndrome (ARDS) prediction model based on electronic health record (EHR) data with good discriminative performance has been developed. The results demonstrate the feasibility of a machine... read more
The Association of Clinical Variables and the Development of Specified Chronic Conditions in ICU Survivors
Clinical variables, especially the reason for ICU admission, are associated with the development of chronic conditions after ICU discharge. Therefore, these clinical variables should be considered when organizing follow-up... read more
Video Laryngoscopy Does Not Improve Intubation Outcomes in Critical Patients
On the basis of the results of this study, we conclude that, compared with direct laryngoscopy, video laryngoscopy does not improve intubation outcomes in emergency and critical patients. Prehospital intubation is even worsened... read more
Apneic Oxygenation As a Quality Improvement Intervention in an Academic PICU
Implementation of apneic oxygenation in PICU was feasible, and was associated with significant reduction in moderate and severe oxygen desaturation. Use of apneic oxygenation should be considered when intubating critically... read more
New Hope for Concussions TBI & PTSD
Dr. Larry Komer and Joan Chandler Komer offer new hope to those with brain injuries. Millions of people of all ages experience concussions. Many others have a more serious event known as a traumatic brain injury. Battlefield... read more
Effects of Sepsis on Mortality in Critically Ill Patients 2 Years After ICU Discharge
Compared with patients without sepsis, those with sepsis have higher mortality in the intensive care unit and have more pain, hospital readmissions, and functional decline within 2 years after discharge. During the study,... read more
Delayed Interhospital Transfer of Critically Ill Patients with Surgical Sepsis
Patients with surgical sepsis who spent more than 24 hours at an outside facility prior to transfer had greater initial illness severity, longer intervals between admission and source control, and more nosocomial infections... read more
Stress Management Intervention to Prevent PICS-Family in Patients’ Spouses
Sensation Awareness Focused Training (SĀF-T) intervention during the ICU stay is feasible, acceptable, and may improve family caregivers' post-ICU outcomes. Larger clinical trial to assess the effectiveness of SĀF-T in... read more
Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI
In adults with severe traumatic brain injury (TBI), prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital. A total of... read more
Association Between Hospital Staffing Models and Failure to Rescue
Low failure to rescue (FTR) hospitals had significantly more staffing resources than high FTR hospitals. Although hiring additional staff may be beneficial, there remain significant financial limitations for many hospitals... read more
Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU
Pediatric acute respiratory distress syndrome (ARDS) contributes to a significant burden in the PICU of a developing country and is associated with significantly higher mortality. Infection remains the most common etiology.... read more
The Fragility and Reliability of Conclusions of Anesthesia and Critical Care Randomized Trials With Statistically Significant Findings
Statistically significant results in anesthesia and critical care randomized controlled trials are often fragile, and study conclusions are frequently affected by spin. Routine calculation of the Fragility Index in medical... read more
