Oral Health Care and VAP in ICU Patients
Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more
Prone Position: Achieving Nutritional Goals
Critically ill patients in the prone position had longer hospital stays and higher mortality rates, while being more likely to initiate and remain on enteral nutrition for a longer period. However, no significant differences... read more
Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence... read more
Nebulized Long-Acting Bronchodilators to Treat ARF in an Older Patients
Although long-acting bronchodilators are not approved to treat acute respiratory failure (ARF), the older adult in this case clinically improved after three doses of revefenacin and arformoterol. Additional studies are... read more
Different Anticoagulation Regimens Effectiveness in Critically Ill Patients
This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy... read more
Awareness Strategies and the Physiological Pain Impact in Prehospital Analgesia Management
Developing awareness strategies for prehospital pain management could improve analgesic outcomes, but further research is needed to understand the physiological impact of pain on vital systems. Investigating these dynamics... read more
COPD: Heterogeneity and Personalized Treatment
This book explains how analysis of the heterogeneity of chronic obstructive pulmonary disease (COPD) enhances understanding of the condition and leads to improved, personalized treatment. State of the art knowledge is presented... read more
Methylprednisolone vs. Hydrocortisone in Septic Shock Patients
Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more
Elevated BCR Risk Factor For CHF in Critically Ill COPD Patients
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular... read more
Assessing the Risk of Poor Clinical Outcomes in Preterm Neonates with Late-onset Sepsis
A predictive calculator for assessing the risk of poor clinical outcomes in preterm neonates with late-onset sepsis (LOS) has been developed. By leveraging readily available clinical data at the time of blood culture collection,... read more
Patients Under Mechanical Ventilation Are Highly Perceptive
This meta-synthesis provides insights into the perception of intensive care patients under Mechanical Ventilation (MV) who are continuously observing their own lives. This process is complex and involves a highly differentiated... read more
Hemoglobin Glycation Index vs. Adverse Outcomes in Critically Ill Patients with Myocardial Infarction
Based on the MIMIC-IV database, this study found that lower HGI is significantly associated with an increased risk of short-, mid- and long-term all-cause mortality in critically ill myocardial infarction (MI) patients. As... read more
Thromboprophylaxis Preferences in the ICU
Low-molecular-weight heparin (LMWH) was the preferred agent for thromboprophylaxis in critically ill patients. There was considerable variation in the application of LMWH for prophylaxis, reflected by the use of different... read more
Machine Learning Model for Predicting Acute Pancreatitis Mortality in the ICU
Machine learning model has been proved to be superior to existing prediction scores for mortality prediction of Acute Pancreatitis (AP). The use of most of previous ML models is limited in clinical practice, mainly due... read more
Electrical Impedance Tomography for PEEP Titration in ARDS Patients
ARDS patients may benefit from electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration. The real-time bedside assessment of regional ventilation provided by EIT may result in improved... read more
Association Between Aspirin and AKI in Critical Patients with Chest Trauma
This analysis of two datasets reveals that aspirin usage is associated with an increased risk of acute kidney injury (AKI) in critical patients with chest trauma; however, no significant association was observed between the... read more
Predicting SA-AKI Mortality Using XGBoost Algorithm
The integration of advanced techniques with the XGBoost algorithm yielded a highly accurate and interpretable model for predicting Sepsis-Associated Acute Kidney Injury (SA-AKI) mortality across diverse populations. It... read more
Pharmacokinetics of Opioid Infusions in the Adult ICU Setting
To counter these pharmacokinetics (PKs) alterations, new therapeutic avenues must be further explored in the ICU to individualize opioid infusions. Embase, MEDLINE, PubMed, CINAHL, and Evidence-Based Medicine Reviews (EBMR)... read more
Clinical Efficacy of Nafamostat Mesylate-assisted CRRT Therapy in SA-AKI Patients
Nafamostat Mesylate (NM)-assisted continuous renal replacement therapy (CRRT) therapy significantly improves the therapeutic efficacy of patients with sepsis-associated acute kidney injury (SA-AKI). This combined approach... read more
Impact of Short-Acting Beta-Blockers on the Outcomes of Septic Shock Patients
In patients with septic shock, short-acting beta-blockers may improve survival and reduce new-onset tachyarrhythmias. However, these findings were based on low certainty evidence and given ongoing concerns regarding adverse... read more
Thiamine and Ascorbic Acid in Sepsis and Septic Shock
Exploring the individual and synergistic effects of ascorbic acid and thiamine on key pathways implicated in sepsis pathophysiology has not yielded unequivocal evidence supporting their use without concomitant corticosteroids. Heterogeneity... read more
Evaluation of Vitamin D Supplementation in Critically Ill Patients
Vitamin D supplementation in critically ill patients may shorten ICU or hospital length of stay, improve SOFA scores, or reduce the duration of mechanical ventilation. Its ability to lower 28-day mortality remains uncertain,... read more
