Benzodiazepines and Delirium in ICU Patients
We have learned an extraordinary amount about ICU delirium over the last 2 decades, which is associated with increased duration of mechanical ventilation, length of hospital stay, long-term cognitive impairment, and mortality... read more
An Alternative Consent Process for Minimal Risk Research in the ICU
Seeking consent for minimal risk research in the ICU poses challenges, especially when the research is time-sensitive. Our aim was to determine the extent to which ICU patients or surrogates support a deferred consent process... read more
The Lactate Dilemma
After a long and exhausting discussion with an inferior human being, a cardiologist, which happens to be an old friend, I decided to write some thoughts about lactate. So, I'll do like I do in my lectures, which is state... read more
Association Between Survival and Time of Day for RRT Calls
Rapid response team activation is less frequent during the early morning and is followed by a spike in mortality in the 7 AM hour. These findings suggest that failure to rescue deteriorating patients is more common overnight.... read more
Selepressin – An Effective Substitute for Norepinephrine
Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Vasopressin is widely used for vasopressor... read more
NIH Herpesvirus Study Leads to Discovery of Potential Broad-Spectrum Antiviral
Scientists studying how regulated herpes simplex virus (HSV) infection unexpectedly found that inhibiting EZH2/1 suppressed viral infection. The research group, from the National Institute of Allergy and Infectious Diseases... read more
Antibiotic Guidelines Improve Prescription Practices for Vulnerable Infants
Yale University School of Medicine neonatal intensive care unit (NICU) significantly reduced the number of cases of late-onset sepsis, a leading cause of death among pre-term infants, by implementing guidelines designed to... read more
Incidence, Prevalence, and Management of MRSA Bacteremia Across Patient Populations
Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or... read more
Impact of PICU Admission on Family Financial Status
A child's pediatric intensive care unit (PICU) admission may have wide-ranging family implications. We assessed nonmedical out-of-pocket expenses (NMOOPEs) and disruptions in work and normal life for parents with a child... read more
Mastering Intensive Care
Is the patient the centre of every action you take in the ICU? Do you exude calm and enthusiastic energy and greet other team members warmly and genuinely? Do you seek pleasure in seeing colleagues grow to become more skilled... read more
Successful Long-Term ECMO for Invasive Pulmonary Aspergillosis
Extracorporeal membrane oxygenation is an established life-saving procedure for severe acute respiratory failure due to various causes. Long-term extracorporeal membrane oxygenation might be considered if the primary causes... read more
A Methodological Study to Develop a Standard Protocol for Central Line Catheter Care of ICU Patients
This study aims to develop a standard operational protocol (SOP) for central line catheter care for nurses. Central line based infection is the most significant complication in critical care setting. It is a challenge for... read more
Delays in Antibiotic Administration for Sepsis
Todd Fraser, MD, speaks with Christopher W. Seymour, MD, MSc, about the article, "Delays From First Medical Contact to Antibiotic Administration for Sepsis," published in Critical Care Medicine. Dr. Seymour's article contends... read more
Controlled Trial to Improve Resident Sign-out in a Medical ICU
Poor sign-out or handover of care may lead to preventable patient harm. Critically ill patients in intensive care units (ICU) are complex and prone to rapid clinical deterioration. If clinical deterioration occurs, timeliness... read more
Whole Body Hyperthermia Appeared to Reduce Depression Symptoms
Whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Results from the current study suggest that WBH holds promise as a safe, rapid-acting, antidepressant... read more
Candida Auris a “Perfect Storm” Superbug
How an invasive fungus got health officials' attention. Try as they might, the infection control specialists at Royal Brompton Hospital could not eradicate the invasive fungus that was attacking already gravely ill patients... read more
Increased ICU Costs for Opioid Overdoses
ICU costs for treating opioid overdose patients increased 58% in a seven-year span, and annual deaths almost doubled, according to a study that included 162 academic hospitals. ICU admissions increased 34% over the study... read more
